Results 81 to 90 of about 7,554 (201)

The Inhibitory Receptor BTLA Controls γδ T Cell Homeostasis and Inflammatory Responses [PDF]

, 2013
Summaryγδ T cells rapidly secrete inflammatory cytokines at barrier sites that aid in protection from pathogens, but mechanisms limiting inflammatory damage remain unclear. We found that retinoid-related orphan receptor gamma-t (RORγt) and interleukin-7 (
Rhode-Kurnow, Antje, Šedý, John R., Bekiaris, Vasileios, Ware, Carl F., Macauley, Matthew G.   +4 more
core   +1 more source

Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes [PDF]

, 2016
This dissertation project focused on understanding the functional role of BTLA on CD8+ Tumor Infiltrating Lymphocytes (TIL) from metastatic melanoma patients.
ritthipichai, krit
core   +1 more source

Decoding the Oncogenic Role of USP22 Through Pan‐Cancer Genomic and Epigenetic Analysis

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Ubiquitin‐specific protease 22, an important catalytic component of the human SAGA (Spt‐Ada‐GcN5 Acetyltransferase) complex, regulates the deubiquitination and methylation of histones, which in turn influences gene expression. Its overexpression alters gene regulation, transcription, cancer progression, and therapy resistance.
Uma Devi A., Prakash Kumar Shukla
wiley   +1 more source

High‐dimensional multiomics reveals perturbations to IL‐6/IL‐6R axis and RUNX3 in CD4+ T cells during third‐trimester pregnancy

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives CD4+ T cells play key roles in regulating immune responses during pregnancy; therefore, we aimed to understand the CD4+ T‐cell surface proteome and transcriptome during pregnancy. Methods CD4+ T cells were analysed in blood and decidua from term pregnancies (> 37 weeks) and non‐pregnant blood.
Jennifer R Habel, Thi H O Nguyen, Natasha de Alwis, E Kaitlynn Allen, Shihan Li, Morgan J Skinner, Jennifer A Juno, Stephen J Kent, Katherine Bond, Deborah A Williamson, Martha Lappas, Natalie J Hannan, Susan Walker, Jan Schroeder, Jeremy Chase Crawford, Paul G Thomas, Katherine Kedzierska, Louise C Rowntree   +17 more
wiley   +1 more source

Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter

, 2017
Purpose: Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown an overall clinical response rate 40%–50% in metastatic melanoma patients.
Luis M. Vence, Laszlo G. Radvanyi, Cara L. Haymaker, Navin Varadarajan, Willem W. Overwijk, Patrick Hwu, Minying Zhang, Andrew Aschenbrenner, Jason Roszik, Melisa Martinez, Xiaohui Yi, Yared Hailemichael, Chantale Bernatchez, Krit Ritthipichai, Charuta Kale, Roza Nurieva   +15 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

B and T lymphocyte attenuator (BTLA) and PD-1 pathway dual blockade promotes antitumor immune responses by reversing CD8+ T-cell exhaustion in non-small cell lung cancer

Frontiers in Immunology
BackgroundImmunotherapies targeting the programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1) have shown great promise for a subset of patients with non-small cell lung cancer (NSCLC).
Yang Zhang, Yang Zhang, Yang Yang, Yang Yang, Yuanyuan Zeng, Yuanyuan Zeng, Qiuxia Qu, Dan Shen, Chuanyong Mu, Wei Lei, Meiqin Su, Jingyu Mao, Lirong Gao, Zeyi Liu, Zeyi Liu, Cheng Chen, Jian-an Huang, Jian-an Huang   +17 more
doaj   +1 more source

Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression [PDF]

, 2010
Graft-versus-host disease (GVHD) causes significant morbidity and mortality in allogeneic hematopoietic stem cell transplantation (aHSCT), preventing its broader application to non–life-threatening diseases.
Michelle M. Sandau, Sandau, Michelle M, Rapaport, Aaron S, Aaron S. Rapaport, Chyi-Song Hsieh, Theresa L. Murphy, Marco Colonna, Satpathy, Ansuman, Ansuman Satpathy, Matthias Stelljes, Murphy, Theresa L, Edelson, Brian T, Mashayekhi, Mona, Colonna, Marco, Hsieh, Chyi-Song, Albring, Jörn C, Murphy, Kenneth M, Brian T. Edelson, Stephanie K. Lathrop, Mona Mashayekhi, Lathrop, Stephanie K, Stelljes, Matthias, Jörn C. Albring, Kenneth M. Murphy   +23 more
core   +1 more source

Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice

ImmunoTargets and Therapy
Léa Gherardi,* Lucie Aubergeon,* Mélanie Sayah, Jean-Daniel Fauny, Hélène Dumortier, Fanny Monneaux CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg, 67084, France&ast ...
Gherardi L, Aubergeon L, Sayah M, Fauny JD, Dumortier H, Monneaux F   +5 more
doaj  

Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness

Molecular Medicine, 2018
Background Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiologic alterations.
Sean F. Monaghan, Debasree Banerjee, Chun-Shiang Chung, Joanne Lomas-Neira, Kamil J. Cygan, Christy L. Rhine, William G. Fairbrother, Daithi S. Heffernan, Mitchell M. Levy, William G. Cioffi, Alfred Ayala   +10 more
doaj   +1 more source