Results 71 to 80 of about 7,554 (201)
, 2018 B-and T-lymphocyte attenuator (BTLA) is a co-inhibitory molecule which was identified as a marker for Th1 cells. However, nowadays it is known that BTLA is most abundantly expressed on B cells. Also, we showed earlier that BTLA was specifically expressed
Schaftenaar, F.H. +11 more
core +1 more source
Advanced Science, Volume 13, Issue 35, 24 June 2026.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source
Investigation of BTLA tagging variants with risk of esophagogastric junction adenocarcinoma [PDF]
Bioscience Reports, 2019 Abstract Background: Variants in B- and T-lymphocyte attenuator (BTLA) gene are likely to affect the function of BTLA protein. Methods: In the present case–control study, we selected BTLA tagging single-nucleotide polymorphisms (SNPs) (rs16859629 T>C, rs1982809 G>A, rs2171513 G>A and rs3112270 A>
Weifeng Tang +4 more
openaire +2 more sources
Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway
, 2011 B and T lymphocyte attenuator (BTLA) is a coinhibitory receptor that interacts with herpesvirus entry mediator (HVEM), and this interaction regulates pathogenesis in various immunologic diseases.
倉増, 敦朗 +15 more
core +1 more source
Advanced Science, Volume 13, Issue 35, 24 June 2026.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Intragenic Variations in BTLA Gene Influence mRNA Expression of BTLA Gene in Chronic Lymphocytic Leukemia Patients and Confer Susceptibility to Chronic Lymphocytic Leukemia [PDF]
Archivum Immunologiae et Therapiae Experimentalis, 2016 The aim of this study was to determine the association between polymorphisms in gene encoding B- and T-lymphocyte attenuator (BTLA) and susceptibility to chronic lymphocytic leukemia (CLL) and their influence on mRNA expression of BTLA gene in T and B cells from CLL patients (pts.).
Lidia Karabon +10 more
openaire +3 more sources
CpG-ODN-induced sustained expression of BTLA mediating selective inhibition of human B cells [PDF]
, 2018 BTLA (B- and T-lymphocyte attenuator) is a prominent co-receptor that is structurally and functionally related to CTLA-4 and PD-1. In T cells, BTLA inhibits TCR-mediated activation.
Gertner-Dardenne, Julie +7 more
core
BTLA is differentially expressed in central nervous system metastasis.
, 2023 Metastasis to the brain occurs in a significant fraction of patients with breast cancer and lung cancer (1-3). We mined published RNA-sequencing and multiplexed gene expression data (4, 5), comparing primary and brain metastatic tumor transcriptomes for ...
Shahan Mamoor
core +1 more source
Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation
European Journal of Immunology, Volume 56, Issue 6, June 2026.• pDCs are defined by high surface TFRC expression and dynamic iron flux, distinguishing them from conventional dendritic cell subsets. • In the Iron proteome, pDC are enriched for mitochondrial heme and Fe–S proteins but have similar iron storage to cDC. • Iron chelation does not disrupt pDC type‐1 IFN production. ABSTRACT Plasmacytoid dendritic cells
Carrie Corkish +7 more
wiley +1 more source
CD160 serves as a negative regulator of NKT cells in acute hepatic injury
Nature Communications, 2019 BTLA is established as a negative regulator of natural killer T (NKT) cell function, and share its ligand HVEM with CD160. Here the authors show, by analyzing NKT activation in CD160-deficient mice or with BTLA blockade, that CD160 synergizes with BTLA ...
Tae-Jin Kim +14 more
doaj +1 more source