Results 51 to 60 of about 7,554 (201)
Journal of Immunology Research, 2018 BTLA/HVEM (B and T lymphocyte attenuator/herpes virus entry mediator) pathways play a critical role in T cell suppression in tumor. However, its dynamic changes in different T cell subsets in peripheral blood and their clinical significance are largely ...
Jiayu Liu +4 more
doaj +1 more source
Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights
Reviews in Medical Virology, Volume 36, Issue 5, September 2026.ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani +2 more
wiley +1 more source
BMC Immunology, 2020 Background The use of anti-B cell based therapies in immune-mediated diseases targeting general B cell markers or molecules important for B cell function has increased the clinical needs of monitoring B cell subpopulations.
Susanne Axelsson +5 more
doaj +1 more source
OncoImmunology, 2021 Clinical trials involving anti-programmed cell death protein-1 (anti-PD-1) failed to demonstrate improved overall survival in glioblastoma (GBM) patients.
John Choi +15 more
doaj +1 more source
BTLA-HVEM Couple in Health and Diseases: Insights for Immunotherapy in Lung Cancer
Frontiers in Oncology, 2021 Lung cancer is the leading cause of cancer deaths worldwide. Immunotherapies (IT) have been rapidly approved for lung cancer treatment after the spectacular results in melanoma.
Clemence Demerlé +2 more
doaj +1 more source
Clinical significance of BTLA gene expression and rs1982809 polymorphism in pan-cancer
, 2023 The association between the B and T lymphocyte attenuator (BTLA) gene rs1982809 polymorphism and cancer susceptibility has been reported, but these findings are inconsistent.
Shiyu Pan (7177622) +3 more
core +1 more source
B and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation [PDF]
Iranian Journal of Immunology, 2016 Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear.
Yongan Liu +5 more
doaj
The Role of B and T Lymphocyte Attenuator in Respiratory System Diseases
Frontiers in Immunology, 2021 B and T lymphocyte attenuator (BTLA), an immunomodulatory molecule widely expressed on the surface of immune cells, can influence various signaling pathways and negatively regulate the activation and proliferation of immune cells by binding to its ligand
Zheng Deng +5 more
doaj +1 more source
iMeta, Volume 5, Issue 4, August 2026.Integrated single‐cell RNA sequencing, spectral flow cytometry, immune‐receptor repertoire profiling, and plasma proteomics revealed coordinated peripheral immune remodeling during acute scrub typhus. Patients exhibited expansion of cytotoxic, clonally amplified CD8+ T cells with exhaustion‐associated features, depletion and apoptosis of CD4+ T cells ...
Yijia Guo +13 more
wiley +1 more source
A crucial role for HVEM and BTLA in preventing intestinal inflammation [PDF]
The Journal of Experimental Medicine, 2008 The interaction between the tumor necrosis factor (TNF) family member LIGHT and the TNF family receptor herpes virus entry mediator (HVEM) co-stimulates T cells and promotes inflammation. However, HVEM also triggers inhibitory signals by acting as a ligand that binds to B and T lymphocyte attenuator (BTLA), an immunoglobulin super family member.
Steinberg, Marcos W +8 more
openaire +4 more sources