Results 61 to 70 of about 7,554 (201)

Combined Immunotherapy With Belatacept and BTLA Overexpression Attenuates Acute Rejection Following Kidney Transplantation

Frontiers in Immunology, 2021
BackgroundCostimulatory blockade provides new therapeutic opportunities for ensuring the long-term survival of kidney grafts. The adoption of the novel immunosuppressant Belatacept has been limited, partly due to concerns regarding higher rates and ...
Hengcheng Zhang, Hengcheng Zhang, Zijie Wang, Jiayi Zhang, Zeping Gui, Zhijian Han, Jun Tao, Hao Chen, Li Sun, Shuang Fei, Haiwei Yang, Ruoyun Tan, Anil Chandraker, Min Gu   +13 more
doaj   +1 more source

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance

MedComm, Volume 7, Issue 8, August 2026.
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Mayank Singh, Ajaz A. Bhat   +12 more
wiley   +1 more source

Expression of BTLA on peripheral T cells.

, 2016
T cells of RA patients and healthy controls ran in different times, so the same color might stand for different subtypes of T cells. Dots above to the horizontal line stood for BTLA+ T cells, inferior to the horizontal line stood for BTLA- T cells, right
Junlong Zhang (295628), Yun Liao (160524), Linhui Li (2793397), Lanlan Wang (160537), Yangjuan Bai (314947), Bei Cai (160529), Bin Yang (103252), Zhuochun Huang (779527), Xinle Liu (2793400), Zhiqiang Wu (102384), Weihua Feng (2793394), Wei Wei (21173)   +11 more
core   +1 more source

A cDC1‐NK/T‐Malignant Cell Circuit Drives Immunogenic Remodeling Under PD‐1 Blockade in Gastric Cancer

Cancer Science, Volume 117, Issue 8, Page 2098-2114, August 2026.
Chemotherapy combined with nivolumab reshapes the gastric cancer tumor microenvironment (TME) and is accompanied by an enrichment of reduced cytotoxicity NK (RC‐NK) cells. Rather than acting as classical cytotoxic effectors, these RC‐NK cells appear to shape the TME by promoting an immunostimulatory circuit that engages adaptive immunity.
Takuya Nakatsuru, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Keita H. Nagaoka, Ryo Kamata, Shunsuke A. Sakai, Gaku Yamamoto, Tomoko Y. Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Yuko Ishii, Sai M. Pulukuri, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi   +24 more
wiley   +1 more source

Adenovirus-Mediated CCR7 and BTLA Overexpression Enhances Immune Tolerance and Migration in Immature Dendritic Cells [PDF]

, 2017
Our previous report revealed that immature dendritic cells (imDCs) with adenovirus-mediated CCR7 overexpression acquired an enhanced migratory ability but also exhibited the lower immune tolerance observed in more mature cells.
Xiaochen Jiang, Xiaoyan Feng, Haiming Xin, Zhenyu Gong, Jinhong Zhu, Yalin Tong, Hongcheng Miao   +6 more
core   +1 more source

The Expression of BTLA Was Increased and the Expression of HVEM and LIGHT Were Decreased in the T Cells of Patients with Rheumatoid Arthritis [corrected].

PLoS ONE, 2016
BackgroundCurrently, the pathogenesis of rheumatoid arthritis (RA) is not clearly understood. The LIGHT/HVEM/BTLA co-signaling pathway may be involved in the pathogenesis of RA, although reports on the expression levels of LIGHT, HVEM and BTLA in T ...
Bin Yang, Zhuochun Huang, Weihua Feng, Wei Wei, Junlong Zhang, Yun Liao, Linhui Li, Xinle Liu, Zhiqiang Wu, Bei Cai, Yangjuan Bai, Lanlan Wang   +11 more
doaj   +1 more source

CCT7 Expression Affects the Prognosis of Lung Adenocarcinoma

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background CCT7 is a chaperonin containing tailless complex polypeptide 1 subunit. The study focused on investigating its prognostic significance for lung adenocarcinoma (LUAD). Methods CCT7 expression in LUAD and matched non‐carcinoma lung samples was examined via TCGA database. Besides, we utilized the GEO database and RT‐qPCR for validating
Yue Li, Longqian Wei, Guiyu Feng, Guosheng Li, Jielin Ma, Xiang Gao, Jun Liu, Nuo Yang, Huafu Zhou   +8 more
wiley   +1 more source

Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model Xiphophorus Provides Insights in Disease Control

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Single‐nucleus RNA sequencing analysis of Xiphophorus melanoma, an evolutionary medicine model, revealed cellular heterogeneity that closely mirrors that of human melanoma. Immune and tumor cell subtyping identified an immune‐evasive tumor microenvironment. This melanoma cell atlas provides a framework for investigating conserved cellular and molecular
Yuan Lu, Will Boswell, Rachel Carroll, Maggs X, Yanting Xing, Wesley C. Warren, Manfred Schartl   +6 more
wiley   +1 more source

PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2 [PDF]

, 2020
Blockade antibodies of the immunoinhibitory receptor PD-1 can stimulate the anti-tumor activity of T cells, but clinical benefit is limited to a fraction of patients. Evidence suggests that BTLA, a receptor structurally related to PD-1, may contribute to
Xiaozheng Xu, Haopeng Wang, Guo Fu, Wang, Haopeng, Xu, Xiaozheng, Fu, Guo, Bennett, Eric J, Hu, Yanyan, Zijun Wu, Yunlong Zhao, Yong Jiang, Wu, Zijun, Yanyan Hu, Bowen Hou, Takeya Masubuchi, Yanzhe Ma, Zhao, Yunlong, Masubuchi, Takeya, Eric J. Bennett, Hou, Bowen, Jiang, Yong, Ma, Yanzhe, Amitkumar Fulzele, Hui, Enfu, Enfu Hui, Fulzele, Amitkumar   +25 more
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, Volume 13, Issue 35, 24 June 2026.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source