A Comprehensive Development Strategy in Buccal Drug Delivery [PDF]
AAPS PharmSciTech, 2010 This work combines several methods in an integrated strategy to develop a matrix for buccal administration. For this purpose, tablets containing selected mucoadhesive polymers loaded with a model drug (omeprazole), free or in a complexed form with cyclodextrins, and in the absence and presence of alkali agents were subjected to a battery of tests ...
Ana Figueiras +2 more
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Mucoadhesive Interpolyelectrolyte Complexes for the Buccal Delivery of Clobetasol. [PDF]
Polymers (Basel), 2018 This work aimed to investigate the feasibility to design: (a) a mucoadhesive interpolyelectrolyte complex (IPEC) loaded with clobetasol propionate (CP) intended to treat oral lichen planus and (b) individuate an orodispersible dosage form suitable for its administration.
Garipova VR +4 more
europepmc +5 more sources
Buccal Absorption of Biopharmaceutics Classification System III Drugs: Formulation Approaches and Mechanistic Insights [PDF]
PharmaceuticsBuccal drug delivery emerges as a promising strategy to enhance the absorption of drugs classified under the Biopharmaceutics Classification System (BCS) Class III, characterized by high solubility and low permeability. However, addressing the absorption
Rayan Sabra +4 more
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Buccal and sublingual vaccine delivery
Journal of Controlled Release, 2014 Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination. An important characteristic of mucosal vaccination is its ability to elicit local immune responses, which act against infection at the site of pathogen entry. However, mucosal surfaces are endowed with potent
Kraan, Heleen +5 more
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A new transmucosal drug delivery system for patients with breakthrough cancer pain: the fentanyl effervescent buccal tablet [PDF]
Journal of Pain Research, 2008 Enno FreyeCenter of Ambulatory Pain Medicine, Neuss-Uedesheim, GermanyAbstract: Breakthrough pain, a transitory severe pain with the background of otherwise controlled persistent pain has a prevalence between 52% and 67% in outpatients with cancer ...
Enno Freye
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In Vitro Evaluation of 2D-Printed Edible Films for the Buccal Delivery of Diclofenac Sodium. [PDF]
Materials (Basel), 2018 Printing technologies have recently emerged in the development of novel drug delivery systems toward personalized medicine, to improve the performance of formulations, existing bioavailability patterns, and patients’ compliance.
Eleftheriadis GK +3 more
europepmc +2 more sources
Buccal Thin Films as Potent Permeation Enhancers for Cytisine Transbuccal Delivery [PDF]
Membranes, 2022 Cytisine (CYT) is a powerful anti-smoking compound which could greatly benefit from transbuccal delivery because of both its unfavorable pharmacokinetics after oral administration and its intrinsic ability to permeate the buccal mucosa. This work aims to
Viviana De Caro +3 more
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Buccal Delivery of Nanoparticles
, 2020 The buccal route offers an alternative for drug administration due to its advantages, including the avoidance of the gastrointestinal tract, the hepatic first-pass, enzymatic degradation and chemical instability of certain molecules that would pose a challenge to formulate orally.
Andrea C. Ortiz, Javier O. Morales
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OVERVIEW OF MUCOADHESIVE BIOPOLYMERS FOR BUCCAL DRUG DELIVERY SYSTEMS [PDF]
, 2019 Mucoadhesive dosage forms may be intended for facilitation of prolonged retention time at the application site hence providing drug release in a controlled rate for enhanced improvement of therapeutic activity and its outcome.
MAMAN, PARAMJOT +4 more
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Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone. [PDF]
Polymers (Basel), 2018 Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug,
Ruiz-Rubio L +5 more
europepmc +2 more sources