Results 11 to 20 of about 589,593 (306)

The Buck-Passing Game

Mathematics of Operations Research, 2022
We consider two classes of games in which players are the vertices of a directed graph. Initially, nature chooses one player according to some fixed distribution and gives the player a buck. This player passes the buck to one of the player’s out-neighbors in the graph. The procedure is repeated indefinitely. In one class of games, each player wants to
Roberto Cominetti, Matteo Quattropani, Marco Scarsini   +2 more
openaire   +4 more sources

A Fault-Tolerant DC-DC Converter with Zero Interruption Time Using Capacitor Health Prognosis

International Journal of Prognostics and Health Management, 2023
A high-end critical electronic system is expected to have hundreds of electronic subsystems, which rely on the Power Management Unit (PMU) to be energized.
Preethi Sharma K, Vijayakumar T
doaj   +1 more source

Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction

Nature Communications, 2019
Protein homeostasis maintenance (proteostasis) is critical for cell function, but declines during aging. Here the authors detail a proteostatic checkpoint in Drosophila intestinal stem cells coordinating cell cycle arrest with protein aggregate clearance,
Imilce A. Rodriguez-Fernandez, Yanyan Qi, Heinrich Jasper   +2 more
doaj   +1 more source

Role of immune cells in the removal of deleterious senescent cells

Immunity & Ageing, 2020
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP).
Abhijit Kale, Amit Sharma, Alexandra Stolzing, Pierre-Yves Desprez, Judith Campisi   +4 more
doaj   +1 more source

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

eLife, 2017
The mitochondrial unfolded protein response (UPRmt) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental mitochondrial stress activates UPRmt reporters and extends lifespan.
Martin Borch Jensen, Yanyan Qi, Rebeccah Riley, Liya Rabkina, Heinrich Jasper   +4 more
doaj   +1 more source

A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population

Breast Cancer Research, 2020
Background Previous studies have identified and validated a risk-associated Active transcriptome phenotype commonly expressed in the cancer-adjacent and histologically normal epithelium, stroma, and adipose containing peritumor microenvironment of ...
Taekyu Kang, Christina Yau, Christopher K. Wong, John Z. Sanborn, Yulia Newton, Charlie Vaske, Stephen C. Benz, Gregor Krings, Roman Camarda, Jill E. Henry, Josh Stuart, Mark Powell, Christopher C. Benz   +12 more
doaj   +1 more source

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Cell Reports, 2018
Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed mechanisms of action have not, however, yielded effective disease therapies.
Shankar J. Chinta, Georgia Woods, Marco Demaria, Anand Rane, Ying Zou, Amanda McQuade, Subramanian Rajagopalan, Chandani Limbad, David T. Madden, Judith Campisi, Julie K. Andersen   +10 more
doaj   +1 more source

Viral gene drive in herpesviruses

Nature Communications, 2020
Current gene drive strategies are restricted to sexually reproducing species. Here the authors develop a gene drive in herpesviruses that allows the spread of an engineered trait through a viral population.
Marius Walter, Eric Verdin
doaj   +1 more source

Buck-I-SERV: Uruguay [PDF]

, 2020
STEP Category: Service-Learning and Community ServiceSTEP Expo poster about Buck-I-SERV experience in Uruguay.The Ohio State University Second-year Transformational Experience Program (STEP)Academic Major: Computer Science and ...
Kondaveeti, Raj
core  

Intestinal Inflammation and Stem Cell Homeostasis in Aging Drosophila melanogaster

Frontiers in Cellular and Infection Microbiology, 2013
As a barrier epithelium, the intestinal epithelium has to coordinate physiological functions like digestion and nutrient resorption with the control of commensal bacteria and the prevention of pathogenic infections. It can therefore mount powerful innate
Arshad eAyyaz, Heinrich eJasper
doaj   +1 more source