Results 21 to 30 of about 40,925 (263)

Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction

Nature Communications, 2019
Protein homeostasis maintenance (proteostasis) is critical for cell function, but declines during aging. Here the authors detail a proteostatic checkpoint in Drosophila intestinal stem cells coordinating cell cycle arrest with protein aggregate clearance,
Imilce A. Rodriguez-Fernandez, Yanyan Qi, Heinrich Jasper   +2 more
doaj   +1 more source

A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population

Breast Cancer Research, 2020
Background Previous studies have identified and validated a risk-associated Active transcriptome phenotype commonly expressed in the cancer-adjacent and histologically normal epithelium, stroma, and adipose containing peritumor microenvironment of ...
Taekyu Kang, Christina Yau, Christopher K. Wong, John Z. Sanborn, Yulia Newton, Charlie Vaske, Stephen C. Benz, Gregor Krings, Roman Camarda, Jill E. Henry, Josh Stuart, Mark Powell, Christopher C. Benz   +12 more
doaj   +1 more source

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

eLife, 2017
The mitochondrial unfolded protein response (UPRmt) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental mitochondrial stress activates UPRmt reporters and extends lifespan.
Martin Borch Jensen, Yanyan Qi, Rebeccah Riley, Liya Rabkina, Heinrich Jasper   +4 more
doaj   +1 more source

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Cell Reports, 2018
Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed mechanisms of action have not, however, yielded effective disease therapies.
Shankar J. Chinta, Georgia Woods, Marco Demaria, Anand Rane, Ying Zou, Amanda McQuade, Subramanian Rajagopalan, Chandani Limbad, David T. Madden, Judith Campisi, Julie K. Andersen   +10 more
doaj   +1 more source

Role of immune cells in the removal of deleterious senescent cells

Immunity & Ageing, 2020
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP).
Abhijit Kale, Amit Sharma, Alexandra Stolzing, Pierre-Yves Desprez, Judith Campisi   +4 more
doaj   +1 more source

Viral gene drive in herpesviruses

Nature Communications, 2020
Current gene drive strategies are restricted to sexually reproducing species. Here the authors develop a gene drive in herpesviruses that allows the spread of an engineered trait through a viral population.
Marius Walter, Eric Verdin
doaj   +1 more source

Intestinal Inflammation and Stem Cell Homeostasis in Aging Drosophila melanogaster

Frontiers in Cellular and Infection Microbiology, 2013
As a barrier epithelium, the intestinal epithelium has to coordinate physiological functions like digestion and nutrient resorption with the control of commensal bacteria and the prevention of pathogenic infections. It can therefore mount powerful innate
Arshad eAyyaz, Heinrich eJasper
doaj   +1 more source

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1

Cell Reports, 2016
Summary: Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, including ...
Karla A. Mark, Kathleen J. Dumas, Dipa Bhaumik, Birgit Schilling, Sonnet Davis, Tal Ronnen Oron, Dylan J. Sorensen, Mark Lucanic, Rachel B. Brem, Simon Melov, Arvind Ramanathan, Bradford W. Gibson, Gordon J. Lithgow   +12 more
doaj   +1 more source

State Switched Discrete-Time Model and Digital Predictive Voltage Programmed Control for Buck Converters

Energies, 2020
Switched mode power converters are nonlinear systems, and it is a constant challenge to improve their modeling accuracy and control performance. In this paper, a State Switched Discrete-time Model (SSDM) is proposed, which achieves a higher accuracy at a
Wei Wang, Gaoshuai Shen, Run Min, Qiaoling Tong, Qiao Zhang, Zhenglin Liu   +5 more
doaj   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source