Results 31 to 40 of about 40,925 (263)

Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss

Molecular Neurodegeneration
Background Synapse function is critical for cognition, and synapse loss is highly correlated with cognitive decline in Alzheimer’s disease and related dementias.
Kristeen A. Pareja-Navarro, Christina D. King, Grant Kauwe, Yani Y. Ngwala, Doyle Lokitiyakul, Ivy Wong, Aaryan Vira, Yaofu Liu, Jackson H. Chen, Mahima Sharma, Gabriel Navarro, Olfat Malak, Chuankai Zhou, Birgit Schilling, Tara E. Tracy   +14 more
doaj   +1 more source

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

eLife, 2023
The Maillard reaction, a chemical reaction between amino acids and sugars, is exploited to produce flavorful food ubiquitously, from the baking industry to our everyday lives.
Muniesh Muthaiyan Shanmugam, Jyotiska Chaudhuri, Durai Sellegounder, Amit Kumar Sahu, Sanjib Guha, Manish Chamoli, Brian Hodge, Neelanjan Bose, Charis Amber, Dominique O Farrera, Gordon Lithgow, Richmond Sarpong, James J Galligan, Pankaj Kapahi   +13 more
doaj   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Detection of extracellular amyloid beta aggregates by an Aducanumab-based synNotch receptor: an in vitro proof-of-concept study

Journal of Translational Medicine
Background Synthetic Notch (synNotch) receptors are a powerful gene regulation platform that activate transcription in response to membrane-bound ligands and extracellular matrix components, with emerging applications in cancer, autoimmunity, and ...
Nicholas J. Bergo, Suckwon Lee, Cynthia J. Siebrand, Zachary Mayeri, Julie K. Andersen, Chaska C. Walton   +5 more
doaj   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Enhanced Photocatalytic H2O2 Production on Terpyridine‐Based Acrylonitrile‐Linked Covalent Organic Frameworks with Asymmetric Localized Electron Distribution

Advanced Materials, EarlyView.
Asymmetric localized electron distribution has been optimized in covalent organic frameworks to enhance *O2 adsorption and facilitate charge transfer, boosting photocatalytic two‐electron transfer oxygen reduction toward H2O2 production from water and air.
Qinglan Zhao, Mengmeng Ce, Hengtao Lei, Tianyun Jin, Zhipeng Xie, Yushen Liu, Shengyi Yang, Xinwen Ou, Mohammad Farhadpour, Song‐Zhu Kure‐Chu, Xuan‐He Liu, Liang Zhang, Jimmy C. Yu   +12 more
wiley   +1 more source

A human neuron Alzheimer’s disease model reveals barriers to senolytic translatability

Alzheimer’s Research & Therapy
Therapeutic successes in mouse models of Alzheimer’s disease (AD) largely fail to translate into clinical trials, with experimental drugs rarely validated in human models before being administered to humans.
Chaska C. Walton, Ellen Wang, Suckwon Lee, Cynthia J. Siebrand, Nicholas J. Bergo, Zachary Mayeri, Julie K. Andersen   +6 more
doaj   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source

Chimeric antigen receptors discriminate between tau and distinct amyloid-beta species

Journal of Translational Medicine
Background The lack of a definitive cure for Alzheimer's disease (AD) is fueling the search for innovative therapeutic strategies. Having revolutionized cancer immunotherapy, immune cell engineering with chimeric antigen receptors (CAR) is being explored
Cynthia J. Siebrand, Nicholas J. Bergo, Suckwon Lee, Julie K. Andersen, Chaska C. Walton   +4 more
doaj   +1 more source

Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function

Neurobiology of Disease, 2020
Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced ...
Nikhita Anand, Angelina Holcom, Michael Broussalian, Minna Schmidt, Shankar J. Chinta, Gordon J. Lithgow, Julie K. Andersen, Manish Chamoli   +7 more
doaj   +1 more source