Results 21 to 30 of about 588,476 (307)

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

eLife, 2023
The Maillard reaction, a chemical reaction between amino acids and sugars, is exploited to produce flavorful food ubiquitously, from the baking industry to our everyday lives.
Muniesh Muthaiyan Shanmugam, Jyotiska Chaudhuri, Durai Sellegounder, Amit Kumar Sahu, Sanjib Guha, Manish Chamoli, Brian Hodge, Neelanjan Bose, Charis Amber, Dominique O Farrera, Gordon Lithgow, Richmond Sarpong, James J Galligan, Pankaj Kapahi   +13 more
doaj   +1 more source

Vacaville, California, Tree Pruners’ Strike of 1932 [PDF]

, 1990
[Excerpt] Two days after the November 1932 elections, newly elected California congressman Frank H. Buck provoked a massive tree pruners\u27 strike when he announced a wage cut for pruners on his ranch from $1.40 for an eight-hour day to $1.25 for a nine-
Bronfenbrenner, Kate
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Detection of extracellular amyloid beta aggregates by an Aducanumab-based synNotch receptor: an in vitro proof-of-concept study

Journal of Translational Medicine
Background Synthetic Notch (synNotch) receptors are a powerful gene regulation platform that activate transcription in response to membrane-bound ligands and extracellular matrix components, with emerging applications in cancer, autoimmunity, and ...
Nicholas J. Bergo, Suckwon Lee, Cynthia J. Siebrand, Zachary Mayeri, Julie K. Andersen, Chaska C. Walton   +5 more
doaj   +1 more source

Concentrações plasmáticas de testosterona, triiodotironina (T3) e tiroxina (T4) em bodes submetidos ao estresse calórico Plasma concentrations of testosterone, triiodothyronine (T3), and thyroxine (T4) in bucks submitted to heat stress

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2008
Para verificar o efeito do estresse calórico (EC) nas concentrações plasmáticas de testosterona, triiodotironina (T3) e tiroxina (T4), oito bodes, das raças Saanen (n=4) e Alpina (n=4), foram mantidos em câmara bioclimática, sob condições de ...
L.A. Coelho, A. Sasa, S.D. Bicudo, J.C.C. Balieiro   +3 more
doaj   +1 more source

Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function

Neurobiology of Disease, 2020
Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced ...
Nikhita Anand, Angelina Holcom, Michael Broussalian, Minna Schmidt, Shankar J. Chinta, Gordon J. Lithgow, Julie K. Andersen, Manish Chamoli   +7 more
doaj   +1 more source

Integrity and passion in teaching [PDF]

, 2008
Issue topic: Festschrift in honour of Erwin ...
Lund, Kristine
core   +2 more sources

​Did a Non‐Medical Biosimilar Switching Policy Cause an Increase in Non‐Biologic/Biosimilar Health Care Resource Utilization or Cost in Patients With Inflammatory Arthritis?

Arthritis Care &Research, EarlyView.
Objective This study aimed to evaluate the impact of a series of policies that mandated switching patients with inflammatory arthritis (IA) from an originator biologic to a biosimilar in British Columbia, Canada, on health care resource use and cost.
HaoHung Dang, Sandra Blitz, Nick Bansback, Michael Law, Mark Harrison   +4 more
wiley   +1 more source

A human neuron Alzheimer’s disease model reveals barriers to senolytic translatability

Alzheimer’s Research & Therapy
Therapeutic successes in mouse models of Alzheimer’s disease (AD) largely fail to translate into clinical trials, with experimental drugs rarely validated in human models before being administered to humans.
Chaska C. Walton, Ellen Wang, Suckwon Lee, Cynthia J. Siebrand, Nicholas J. Bergo, Zachary Mayeri, Julie K. Andersen   +6 more
doaj   +1 more source

Role of immune cells in the removal of deleterious senescent cells

Immunity & Ageing, 2020
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP).
Abhijit Kale, Amit Sharma, Alexandra Stolzing, Pierre-Yves Desprez, Judith Campisi   +4 more
doaj   +1 more source