Results 91 to 100 of about 308,111 (305)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

CRYOPRESERVATION OF DORMANT FRUIT TREE SHOOTS [KRYOPREZERVACE DORMANTNÍCH VÝHONŮ OVOCNÝCH DŘEVIN] [PDF]

Vědecké Práce Ovocnářské
In 2021–2024, cryopreservation experiments focused on dormant shoots of pome and stone fruit trees were conducted. The classic freezing protocol, which uses single-nodal segments, was modified towards segments with several nods.
Matěj Semerák, Alexandra Slámová
doaj   +1 more source

Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy [PDF]

, 2019
BACKGROUND: Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy.
Elezkurtaj, Sefer, Horst, David, Kruschewski, Martin, Müller, Alice Josephine, Neumann, Konrad, Sparschuh, Halina, Trotsyuk, Iryna   +6 more
core   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Comparison of GUS activity in self-rooting and budded primary trans/ormant plants in Hevea brasiliensis [PDF]

, 2008
Successful both somatic embryogenesis and Agrobacterium tumefaciens-mediated genetic transformation systems have been developed in PB260 clone. Several transgenic callus lines and plants expressing two reporter genes (gusA and/or GFP) and CuZnSOD gene ...
Benistant, Elise, Lardet, Ludovic, Leclercq, Julie, Martin, Florence, Montoro, Pascal, Oliver, Gérald   +5 more
core  

Eclipsing Binaries with Possible Light-Time Effect

, 2007
The period changes of six eclipsing binaries have been studied with focus on the light-time effect. With the least squares method we also calculated parameters of such an effect and properties of the unresolved body in these systems.
B. Cester, E. Budding, E. Budding, E.M. Halbedel, H. Frieboes-Conde, H.M.K. Naimiy, J.B. Irwin, J.H. Applegate, Luboš Brát, Miloslav Zejda, P. Mayer, Petr Zasche, Y. Yang   +12 more
core   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

PERTUMBUHAN MATA TUNAS JERUK KEPROK (CITRUS NOBILIS) HASIL OKULASI PADA BERBAGAI MEDIA TANAM DAN UMUR BATANG BAWAH ROUGH LEMON (C. JAMBHIRI)

Jurnal Ilmu Pertanian Indonesia, 2013
The objective of this study was to evaluate keprok (Citrus nobilis) budding seed development on various growing media and age of C. jambhiri rootstock. The design of experiment was complete randomized groups with 2 factors and 3 replications. The growing
Tatiek Kartika Suharsi, Ananda Dian Puspita Sari   +1 more
doaj  

Bifurcation analysis of a model of the budding yeast cell cycle

, 2004
We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
core   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source