Late domain dependent E-cadherin recruitment into extracellular vesicles [PDF]
Frontiers in Cell and Developmental Biology, 2022 E-cadherin, a transmembrane protein involved in epithelial cell-cell adhesion and signaling, is found in exosomal fractions isolated from human body fluids.
Sebastian Bänfer +6 more
doaj +4 more sources
Extracellular vesicle surface display of αPD‐L1 and αCD3 antibodies via engineered late domain‐based scaffold to activate T‐cell anti‐tumor immunity [PDF]
Journal of Extracellular VesiclesExtracellular vesicles (EVs) are emerging as promising carriers for the delivery of therapeutic biologics. Genetic engineering represents a robust strategy for loading proteins of interest into EVs.
Rui Chen +9 more
doaj +3 more sources
Functional interchangeability of late domains, late domain cofactors and ubiquitin in viral budding. [PDF]
PLoS Pathogens, 2010 The membrane scission event that separates nascent enveloped virions from host cell membranes often requires the ESCRT pathway, which can be engaged through the action of peptide motifs, termed late (L-) domains, in viral proteins.
Maria Zhadina, Paul D Bieniasz
doaj +4 more sources
The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. [PDF]
PLoS Pathogens, 2016 Arenaviruses cause severe diseases in humans but establish asymptomatic, lifelong infections in rodent reservoirs. Persistently-infected rodents harbor high levels of defective interfering (DI) particles, which are thought to be important for ...
Christopher M Ziegler +9 more
doaj +2 more sources
Continuity of outcome assessment throughout the lifecycle of surgical research: mapping core outcome domains measured in early phase and late phase studies [PDF]
BMC SurgeryBackground Consistent outcome assessment in surgical research, from early phase studies (during introduction and refinement of new procedures) to late phase studies (to establish comparative effectiveness) needs improvement to ensure efficient and safe ...
Christin Hoffmann +7 more
doaj +2 more sources
Virus Hijacks Host Proteins and Machinery for Assembly and Budding, with HIV-1 as an Example
Viruses, 2022 Viral assembly and budding are the final steps and key determinants of the virus life cycle and are regulated by virus–host interaction. Several viruses are known to use their late assembly (L) domains to hijack host machinery and cellular adaptors to be
Chih-Yen Lin +4 more
doaj +1 more source
The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle
Viruses, 2021 Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of the
Bo Meng, Andrew M. L. Lever
doaj +1 more source
Life, 2023 Cellular communication depends heavily on the participation of vesicular systems generated by most cells of an organism. Exosomes play central roles in this process. Today, these vesicles have been characterized, and it has been determined that the cargo
Manuel Adrián Velázquez-Cervantes +10 more
doaj +1 more source
Jurnal Teknologi Informasi dan Ilmu Komputer, 2021 Sebuah organisasi terkadang membutuhkan solusi untuk permasalahan optimasi lintas domain. Permasalahan optimasi lintas domain merupakan permasalahan yang memiliki karakteristik berbeda, misalnya antar domain optimasi penjadwalan, rute kendaraan, bin ...
Anang Firdaus +2 more
doaj +1 more source
Arenavirus Budding: A Common Pathway with Mechanistic Differences
Viruses, 2013 The Arenaviridae is a diverse and growing family of viruses that includes several agents responsible for important human diseases. Despite the importance of this family for public health, particularly in Africa and South America, much of its biology ...
Svenja Wolff +2 more
doaj +1 more source