Late domain dependent E-cadherin recruitment into extracellular vesicles [PDF]
Frontiers in Cell and Developmental Biology, 2022 E-cadherin, a transmembrane protein involved in epithelial cell-cell adhesion and signaling, is found in exosomal fractions isolated from human body fluids.
Sebastian Bänfer +6 more
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The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. [PDF]
PLoS Pathogens, 2016 Arenaviruses cause severe diseases in humans but establish asymptomatic, lifelong infections in rodent reservoirs. Persistently-infected rodents harbor high levels of defective interfering (DI) particles, which are thought to be important for ...
Christopher M Ziegler +9 more
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Extracellular vesicle surface display of αPD‐L1 and αCD3 antibodies via engineered late domain‐based scaffold to activate T‐cell anti‐tumor immunity [PDF]
Journal of Extracellular VesiclesExtracellular vesicles (EVs) are emerging as promising carriers for the delivery of therapeutic biologics. Genetic engineering represents a robust strategy for loading proteins of interest into EVs.
Rui Chen +9 more
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Functional interchangeability of late domains, late domain cofactors and ubiquitin in viral budding. [PDF]
PLoS Pathogens, 2010 The membrane scission event that separates nascent enveloped virions from host cell membranes often requires the ESCRT pathway, which can be engaged through the action of peptide motifs, termed late (L-) domains, in viral proteins.
Maria Zhadina, Paul D Bieniasz
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Replacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus release via interaction with TSG101 [PDF]
Virology, 2015 The ORF3 protein of hepatitis E virus (HEV) contains a “PSAP” amino acid late domain motif, which allows for interaction with the endosomal sorting complexes required for transport (ESCRT) pathway aiding virion release.
X J Meng, Scott Kenney
exaly +4 more sources
Pathogens, 2021 Fusarium and late blight (fungal diseases of cereals and potatoes) are among the main causes of crop loss worldwide. A key element of success in the fight against phytopathogens is the timely identification of infected plants and seeds.
Nikita V. Penkov +6 more
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A PLPPV sequence in the p8 region of Gag provides late domain function for mouse mammary tumor virus [PDF]
Virology, 2019 David E Ott, Lori V Coren
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Virus Hijacks Host Proteins and Machinery for Assembly and Budding, with HIV-1 as an Example
Viruses, 2022 Viral assembly and budding are the final steps and key determinants of the virus life cycle and are regulated by virus–host interaction. Several viruses are known to use their late assembly (L) domains to hijack host machinery and cellular adaptors to be
Chih-Yen Lin +4 more
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The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle
Viruses, 2021 Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of the
Bo Meng, Andrew M. L. Lever
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Life, 2023 Cellular communication depends heavily on the participation of vesicular systems generated by most cells of an organism. Exosomes play central roles in this process. Today, these vesicles have been characterized, and it has been determined that the cargo
Manuel Adrián Velázquez-Cervantes +10 more
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