Domains have been identified in the Gag proteins of a number of retroviruses, and in the matrix proteins of the rhabdoviruses and filoviruses, that play a critical role in the pinching off of virus particles from the plasma membrane. These sequences are collectively termed late or L domains to reflect their function late in the virus budding process ...
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CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release
Cellular ESCRT machinery plays pivotal role in HIV-1 budding and release. Extracellular stimuli that modulate HIV-1 egress are currently unknown. We found that CCL2 induced by HIV-1 clade B (HIV-1B) infection of macrophages enhanced virus production ...
David O Ajasin +9 more
doaj +1 more source
Importance of the N-terminal domain of the Qb-SNARE Vti1p for different membrane transport steps in the yeast endosomal system. [PDF]
SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) on transport vesicles and target membranes are crucial for vesicle targeting and fusion.
Michael Gossing +2 more
doaj +1 more source
Strato-structural evolution of the deep-water Orange Basin: constraints from 3D reflection seismic data [PDF]
Deep-water fold-and-thrust belt (DWFTB) systems are gravity-driven collapse structures often found in passive margin settings and are comprised of a linked up-dip extensional domain, central transitional/translational domain, and down-dip compressional ...
N. G. Maduna +3 more
doaj +1 more source
Application of multisection recursive convolution in 3D FETD-FABC simulations [PDF]
The multisection recursive convolution (MS-RC) methodology is successfully applied to the finite element time domain floquet absorbing boundary condition modeling of doubly periodic structures.
Cai, Yong +3 more
core +1 more source
Importance of Viral Late Domains in Budding and Release of Enveloped RNA Viruses [PDF]
Late assembly (L) domains are conserved sequences that are necessary for the late steps of viral replication, acting like cellular adaptors to engage the ESCRT membrane fission machinery that promote virion release. These short sequences, whose mutation or deletion produce the accumulation of immature virions at the plasma membrane, were firstly ...
Lisa Welker +2 more
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Faster 3D finite element time domain : Floquet absorbing boundary condition modelling using recursive convolution and vector fitting [PDF]
A recursive convolution (RC) based on the vector fitting (VF) method and triangular temporal basis functions is employed to compute the Floquet absorbing boundary condition (FABC) formulation in the vector 3D finite element time-domain (FETD) modelling ...
Cai, Yong, Mias, Christos
core +1 more source
Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases
To define the links between paramyxovirus budding and cellular ESCRT machinery, we previously identified angiomotin-like 1 (AMOTL1) in a screen for host factors that bind to the matrix (M) protein of parainfluenza virus 5 (PIV5).
Greeshma Ray +2 more
doaj +1 more source
Diversity of Raft-Like Domains in Late Endosomes
Late endosomes, the last sorting station in the endocytic pathway before lysosomes, are pleiomorphic organelles composed of tubular elements as well as vesicular regions with a characteristic multivesicular appearance, which play a crucial role in intracellular trafficking.
Sobo, K. +4 more
openaire +10 more sources
Multimodal imaging reveals the spatiotemporal dynamics of recollection. [PDF]
Functional MRI research suggests that different frontal and parietal cortical regions support strategic processes that are engaged at different stages of recollection, from pre-retrieval processing of a cue to post-retrieval maintenance and evaluation of
Henson, Richard N. +5 more
core +1 more source

