Results 11 to 20 of about 672,964 (288)
Domain-wall formation in late-time phase transitions [PDF]
Physical Review D, 1992 We examine domain wall formulation in late time phase transitions. We find that in the invisible axion domain wall phenomenon, thermal effects alone are insufficient to drive different parts of the disconnected vacuum manifold. This suggests that domain walls do not form unless either there is some supplemental (but perhaps not unreasonable) dynamics ...
, Kolb, , Wang
core +13 more sources
Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4. [PDF]
Sci Rep, 2019 AbstractThe recognition of PPxY viral Late domains by the third WW domain of the HECT-E3 ubiquitin ligase NEDD4 (hNEDD4-WW3) is essential for the completion of the budding process of numerous enveloped viruses, including Ebola, Marburg, HTLV1 or Rabies. hNEDD4-WW3 has been validated as a promising target for the development of novel host-oriented broad
Iglesias-Bexiga M +7 more
europepmc +14 more sources
Perbandingan Metode Penyelesaian Permasalahan Optimasi Lintas Domain dengan Pendekatan Hyper-Heuristic Menggunakan Algoritma Reinforcement-Late Acceptance [PDF]
Jurnal Teknologi Informasi dan Ilmu Komputer, 2021 Sebuah organisasi terkadang membutuhkan solusi untuk permasalahan optimasi lintas domain. Permasalahan optimasi lintas domain merupakan permasalahan yang memiliki karakteristik berbeda, misalnya antar domain optimasi penjadwalan, rute kendaraan, bin ...
Anang Firdaus +2 more
doaj +3 more sources
Refined study of the interaction between HIV-1 p6 late domain and ALIX [PDF]
Retrovirology, 2008 The interaction between the HIV-1 p6 late budding domain and ALIX, a class E vacuolar protein sorting factor, was explored by using the yeast two-hybrid approach. We refined the ALIX binding site of p6 as being the leucine triplet repeat sequence (Lxx)4 (
Gerlier Denis +4 more
doaj +3 more sources
A Bipartite Late-Budding Domain in Human Immunodeficiency Virus Type 1 [PDF]
Journal of Virology, 2003 ABSTRACT Human immunodeficiency virus type 1 (HIV-1) encodes a PTAP motif within the p6 domain of Gag that recruits Tsg101 and associated factors to facilitate virion budding. In this study, we use trans -complementation assays to demonstrate that the PTAP motif acts synergistically with additional p6 ...
Martin-Serrano, J, Bieniasz, P D
openaire +5 more sources
Separation and Characterization of Late Endosomal Membrane Domains [PDF]
Journal of Biological Chemistry, 2002 Very little is known about the biophysical properties and the lipid or protein composition of membrane domains presumably present in endocytic and biosynthetic organelles. Here we analyzed the membrane composition of late endosomes by suborganellar fractionation in the absence of detergent.
Kobayashi, Toshihide +9 more
openaire +3 more sources
Identification of Retroviral Late Domains as Determinants of Particle Size [PDF]
Journal of Virology, 1999 ABSTRACT Retroviral Gag proteins, in the absence of any other viral products, induce budding and release of spherical, virus-like particles from the plasma membrane. Gag-produced particles, like those of authentic retrovirions, are not uniform in diameter but nevertheless fall within a fairly narrow distribution of sizes.
L, Garnier +4 more
openaire +2 more sources
Structural basis for viral late-domain binding to Alix [PDF]
Nature Structural & Molecular Biology, 2007 The modular protein Alix is a central node in endosomal-lysosomal trafficking and the budding of human immunodeficiency virus (HIV)-1. The Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for Alix-mediated budding and binds a region of Alix spanning residues 360-702.
Sangho, Lee +4 more
openaire +2 more sources
Functional Replacement of a Retroviral Late Domain by Ubiquitin Fusion [PDF]
Traffic, 2008 Retroviral Gag polyprotein precursors are both necessary and sufficient for the assembly and release of virus‐like particles (VLPs) from infected cells. It is well established that small Gag‐encoded motifs, known as late domains, promote particle release by interacting with components of the cellular endosomal sorting and ubiquitination machinery. The
Anjali, Joshi +4 more
openaire +2 more sources
Arenavirus Budding: A Common Pathway with Mechanistic Differences
Viruses, 2013 The Arenaviridae is a diverse and growing family of viruses that includes several agents responsible for important human diseases. Despite the importance of this family for public health, particularly in Africa and South America, much of its biology ...
Svenja Wolff +2 more
doaj +1 more source