Results 11 to 20 of about 20,955 (176)

Effects of Budesonide on Coronavirus-Associated Receptor and Immune-Mediator Expression in Human Lung Microvascular Endothelial Cells [PDF]

Medicina
Background and Objectives: Inhaled corticosteroids exert broad immunomodulatory effects in patients with chronic airway diseases. However, their direct impact on pulmonary endothelial immune responses and coronavirus-associated receptor expression ...
Izabela Ławska, Adrian Bekier, Maciej Chałubiński, Aleksandra Wardzyńska   +3 more
doaj   +2 more sources

Vedolizumab use for severe chronic enterocolitis in a child with Hoyeraal-Hreidarsson syndrome: A case report. [PDF]

JPGN Rep
Abstract We report a patient with Hoyeraal–Hreidarsson syndrome (HHS), a telomere biology disorder, who developed severe chronic enterocolitis with inflammatory bowel disease‐like features. Vedolizumab led to improvement in stool frequency, reduced fecal calprotectin, and clinical remission without infectious complications.
Chiba Y, Takahashi M, Yoshida T, Tagane S, Shiohata T, Miura S, Akasaka M.   +6 more
europepmc   +2 more sources

Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review. [PDF]

World J Otorhinolaryngol Head Neck Surg
ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
Kennedy DW, Cheng L, Wang DY.
europepmc   +2 more sources

Is It Really Feasible to Use Budesonide–Formoterol as Needed for Mild Persistent Asthma? A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2021
Background: Previous studies suggest that inhaled budesonide-formoterol used as needed could effectively reduce the severe exacerbation of mild persistent asthma.
Xiang Tong, Tao Liu, Zhenzhen Li, Sitong Liu, Hong Fan   +4 more
doaj   +1 more source

Surfactant-Assisted Distal Pulmonary Distribution of Budesonide Revealed by Mass Spectrometry Imaging

Pharmaceutics, 2021
Direct lung administration of budesonide in combination with surfactant reduces the incidence of bronchopulmonary dysplasia. Although the therapy is currently undergoing clinical development, the lung distribution of budesonide throughout the premature ...
Riccardo Zecchi, Pietro Franceschi, Laura Tigli, Barbara Pioselli, Valentina Mileo, Xabier Murgia, Fabrizio Salomone, Giuseppe Pieraccini, Haruo Usada, Augusto F. Schmidt, Noah H. Hillman, Matthew W. Kemp, Alan H. Jobe   +12 more
doaj   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Asthma control with ICS-formoterol reliever versus maintenance ICS and SABA reliever therapy: a post hoc analysis of two randomised controlled trials

BMJ Open Respiratory Research, 2022
Background In randomised controlled trials, as-needed inhaled corticosteroid (ICS)-formoterol reliever therapy reduces severe exacerbation risk compared with maintenance ICS plus short-acting beta2-agonist (SABA) reliever in adolescent and adult asthma ...
, James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Ian Pavord, Jenny Sparks, Lee Hatter, Helen K Reddel, Robert J Hancox, Mark Holliday, Andrew Corin, Daniela Hall, Claire Houghton, Saras Mane, John Martindale, Karen Oldfield, Donah Sabbagh, Alexandra Vohlidkova, Alberto Papi, Allie Eathorne, Pepa Bruce   +21 more
doaj   +1 more source

New Strategies for Improving Budesonide Skin Retention

Pharmaceutics, 2021
The aim of this work was to evaluate the ex vivo effect of the combination of two strategies, complexation with cyclodextrin, and poloxamer hydrogels, for improving water solubility in the dermal absorption of budesonide.
Cristina Padula, Ian Pompermayer Machado, Aryane Alves Vigato, Daniele Ribeiro de Araujo   +3 more
doaj   +1 more source

Efficacy and safety of oral beclomethasone dipropionate and budesonide MMX 5-aminosalicylates or placebo in ulcerative colitis: a systematic review and meta-analysis

Therapeutic Advances in Gastroenterology, 2023
Background: Low bioavailability steroids, including beclomethasone dipropionate (BDP) and budesonide MMX, have been developed to ensure colonic targeting and low systemic activity than systematic corticosteroids in treating patients with ulcerative ...
Brigida Barberio, Ilaria Marsilio, Andrea Buda, Luisa Bertin, Gianluca Semprucci, Annalisa Zanini, Martina Crepaldi, Fabiana Zingone, Edoardo Savarino   +8 more
doaj   +1 more source

Budesonide Analogues Preserve Stem Cell Pluripotency and Delay 3D Gastruloid Development

Pharmaceutics, 2023
Small molecules that can modulate or stabilize cell–cell interactions are valuable tools for investigating the impact of collective cell behavior on various biological processes such as development/morphogenesis, tissue regeneration and cancer ...
Filomena Amoroso, Eduardo Ibello, Federica Saracino, Federica Cermola, Giovanna Ponticelli, Enrica Scalera, Francesca Ricci, Gino Villetti, Gilda Cobellis, Gabriella Minchiotti, Eduardo Jorge Patriarca, Dario De Cesare, Cristina D’Aniello   +12 more
doaj   +1 more source