Comprehensive characterization of metabolites and metabolic profiles in plasma has considerable significance in determining the efficacy and safety of traditional Chinese medicine (TCM) in vivo.
Wen-Long Wei +8 more
doaj +1 more source
Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia [PDF]
Background Placental malfunction in preeclampsia is believed to be a consequence of aberrant differentiation of trophoblast lineages and changes in utero-placental oxygenation.
Larisa Fedorova +6 more
core +3 more sources
From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp. [PDF]
The subgenus Bryophyllum includes about 25 plant species native to Madagascar, and is widely used in traditional medicine worldwide. Different formulations from Bryophyllum have been employed for the treatment of several ailments, including infections ...
Gallego, Pedro Pablo +3 more
core +1 more source
Arenobufagin causes ferroptosis in human gastric cancer cells by increasing rev-erbα expression
Background and aims: Gastric cancer is the fifth most diagnosed malignant tumor worldwide with limited effective chemotherapy. Ferroptosis is a new type of programmed cell death, which is becoming as a novel therapeutic target for tumors.
Ke Chen +6 more
doaj +1 more source
Biosystematics studies on medicinal plant Urginea indica Kunth. liliaceae - A review [PDF]
Indian squill, Urginea spp. is a very important and rare medicinal plant endemic to India, Africa and Meditteranian Regions. It has magical potential to heal many human diseases with cardiatonic, anticarcinomic, anti jaundice, anti dropsy, anti asthmatic,
Bijul Lakshman, A. +2 more
core
Amphibian Strategies Against Attacks by Flies: Host‐Specificity and Threats
Species interactions between Diptera flies and amphibians play a significant role in tropical ecosystems, but their ecology and evolution remain understudied. This review explores the costs flies impose on amphibians, such as pathogen transmission and disruption of communication systems, and highlights the evolutionary strategies employed by both ...
Leonardo Leite Ferraz de Campos +3 more
wiley +1 more source
Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana
Summary Transient expression in Nicotiana benthamiana offers a powerful and versatile platform for rapid production of complex specialized metabolites. Steroidal glycoalkaloids (SGAs) and steroidal saponins produced by members of the Solanaceae family are known for their diverse structures and activities including antimicrobial, anticancer, antiviral ...
Sachin A. Gharat +6 more
wiley +1 more source
Age- and environment-dependent changes in chemical defences of larval and post-metamorphic toads
Background Chemical defences are widespread in animals, but how their production is adjusted to ecological conditions is poorly known. Optimal defence theory predicts that inducible defences are favoured over constitutive defences when toxin production ...
Bálint Üveges +5 more
doaj +1 more source
Dramatic Dietary Shift Maintains Sequestered Toxins in Chemically Defended Snakes [PDF]
Unlike other snakes, most species of Rhabdophis possess glands in their dorsal skin, sometimes limited to the neck, known as nucho-dorsal and nuchal glands, respectively.
Aburaya, Shunsuke +18 more
core +2 more sources
Glioblastoma is a fatal primary malignant brain tumor, and the 5-year survival rate of treated glioblastoma patients still remains <5%. Considering the sustained development of metastasis, tumor recurrence, and drug resistance, there is an urgent need
Bo Yuan +7 more
doaj +1 more source

