Results 91 to 100 of about 1,623 (201)

Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani

, 2007
Twenty strains of filamentous fungi (from nine genera) and four species of bacteria were screened for their capabilities to transform bufadienolides. The highly stereo- and regiospecific isomerization and dehydrogenation of three major bufadienolides ...
Guo, De-An, Jian Zheng, Xiao-Chi Ma, Zheng, Jian, Ma, Xiao-Chi, De-An Guo   +5 more
core   +1 more source

Analysis of bufadienolides in the Chinese drug ChanSu by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry

, 2005
The qualitative analysis of bufadienolides in the Chinese drug ChanSu was performed using high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry (APCI-MS/MS).
Guo, DA, Min Ye, Ye, M, De‐an Guo
core   +1 more source

From Chemical Defense to Drug Discovery: Bioactive Molecules, Pharmacological Activities, and Therapeutic Potential of Rhaebo guttatus and Rhinella marina Secretions

Biology
Amazonian bufonid toads represent an important source of bioactive compounds with promising pharmacological potential. Among them, Rhaebo guttatus and Rhinella marina produce complex cutaneous and parotoid gland secretions composed mainly of ...
Beatriz Evilym Dutra Da Silva, Lucinéia Reuse Albiero, Valéria Dornelles Gindri Sinhorin   +2 more
doaj   +1 more source

Efficient purification of active bufadienolides by a class separationmethod based on hydrophilic solid-phase extraction andreversed-phase high performance liquid chromatography

, 2014
Efficient purification of active bufadienolides by a class separationmethod based on hydrophilic solid-phase extraction andreversed-phase high performance liquid ...
李晓龙, 闫竞宇, 梁鑫淼, 赵伟杰, 刘艳芳, 沈爱金, 王超然   +6 more
core  

Identification of Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

Scientific Reports, 2017
The current study explored the Na+/K+-ATPase (NKA) inhibition-independent proarrhythmic mechanisms of cardiac glycosides (CGs) which are well-known NKA inhibitors. With the cytosolic Ca2+ chelated by EGTA and BAPTA or extracellular Ca2+ replaced by Ba2+,
Cai Hong Koh, Jianjun Wu, Ying Ying Chung, Zhenfeng Liu, Rong-Rong Zhang, Ketpin Chong, Vladimir Korzh, Sherwin Ting, Steve Oh, Winston Shim, Hai-Yan Tian, Heming Wei   +11 more
doaj   +1 more source

Bufadienolides and ouabain enhanced the firing activity of MCs in a concentration-dependent manner.

, 2014
A Original recording from a representative MC illustrated the increase in firing rate and depolarization following application of cinobufagin at 1 µM and 5 µM, respectively.
Ze-Jun Wang (665059), Thomas Heinbockel (665061), Liqin Sun (665060)   +2 more
core   +1 more source

Bufadienolides. XX. 14β-Chloro-bufadienolides

Chemical and Pharmaceutical Bulletin, 1973
KAMANO, YOSHIAKI, PETTIT, GEORGE R.
openaire   +2 more sources

Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides

, 2018
Bufadienolides are cardiotonic steroids (CTS) identified in mammals. Besides Na+/K+-ATPase inhibition, they activate signal transduction via protein–protein interactions.
Luciana S. Amaral, Jainne Martins Ferreira, Danilo Predes, Luis Eduardo M. Quintas, François Noël, José Garcia Abreu   +5 more
core   +1 more source

Discovery of Bufadienolides as a Novel Class of ClC‑3 Chloride Channel Activators with Antitumor Activities

, 2016
ClC-3 chloride (Cl–) channel has been shown to be involved in cell proliferation, cell cycle, and cell migration processes. Herein, we found that a series of bufadienolides isolated from toad venom were a novel class of ClC-3 Cl– channel activators with ...
Gaokeng Xiao (550476), Haiyan Tian (1931950), Hai Luo (1931947), Shanwen Liu (842894), Anita Yiu (1931962), Yuan Li (67017), Dongmei Zhang (89650), Chunlin Fan (1931965), Lixin Chen (300749), Junshan Liu (1931953), Lijuan Deng (203371), Liwei Wang (165815), Zhixiong Ruan (1931956), Ying Wang (11406), Weimin Chen (1931968), Wencai Ye (1931959)   +15 more
core   +1 more source

Untargeted RPLC-UV-Vis-HRMS/MS Profiling of Phenolic Compounds in Naturally Grown Kalanchoe delagoensis Leaves

Compounds
Kalanchoe delagoensis is a Crassulacean acid metabolism (CAM) succulent plant native to Madagascar that has spread as an aggressive invader across subtropical and Mediterranean regions.
Giovanni Ventura, Francesco Busto, Vito Nettis, Elvira De Giglio, Cosima Damiana Calvano, Tommaso R. I. Cataldi   +5 more
doaj   +1 more source