Results 11 to 20 of about 2,339 (195)

Endogenous Bufadienolides, Fibrosis and Preeclampsia

Cardiology Research and Practice, 2019
Frequency of preeclampsia has no tendency to decrease, and it still takes the leading position in the structure of maternal mortality and morbidity worldwide.
Vitaliy A. Reznik, Vladimir A. Kashkin, Natalia I. Agalakova, C. David Adair, Alexei Y. Bagrov   +4 more
doaj   +4 more sources

From Traditional Use to Molecular Mechanisms: A Bioinformatic and Pharmacological Review of the Genus Kalanchoe with In Silico Evidence [PDF]

BioTech
The genus Kalanchoe (Crassulaceae) comprises approximately 125 species of succulents distributed across Madagascar, Africa, Arabia, Australia, Southeast Asia, and tropical America.
Cristián Raziel Delgado-González, Ashutosh Sharma, Margarita Islas-Pelcastre, Mariana Saucedo-García, Eliazar Aquino-Torres, Jaime Pacheco-Trejo, Silvia Armenta-Jaime, Nallely Rivero-Pérez, Alfredo Madariaga-Navarrete   +8 more
doaj   +2 more sources

Comprehensive Analysis of Bufadienolide and Protein Profiles of Gland Secretions from Medicinal Bufo Species [PDF]

Toxins
Toad Venom (TV) is the dried product of toxic secretions from Bufo bufo gargarizans Cantor (BgC) or B. melanostictus Schneider (BmS). Given the increasing medical demand and the severe depletion of wild toads, a number of counterfeit TVs appeared on the ...
Yunge Fang, Liangmian Chen, Pengfei Wang, Yating Liu, Yuxiu Wang, Zhimin Wang, Yue Ma, Huimin Gao   +7 more
doaj   +2 more sources

Insecticidal Bufadienolides from The Leaves of Kalanchoe daigremontiana (Crassulaceae) [PDF]

Jurnal Ilmu Dasar, 2010
Kalanchoe is the biggest genera of Crassulaceae family and distributed in tropical and subtropical regions. This genera is found to be a rich source of biologically active natural products such as triterpenes, flavonoids and steroids.
Wawan Hermawan, Rani Maharani, Sofa Fajriah, Revan Hardiawan, Unang Supratman   +4 more
doaj   +2 more sources

Circular Dichroism of Bufadienolides [PDF]

Croatica Chemica Acta, 1985
With the help of PMO theory a non-empirical sector rule has been derived for the n ~ 1t5* band CD (around 260 nm) of the pentadienolide chromophore of steroidal bufadienolides.
Brian Green, Feliksa Snatzke, George R. Pettit, Gunther Snatzke, Margaret L. Niven, Yoshiaki Kamano   +5 more
core   +3 more sources

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast-Dendritic Cell Crosstalk in Atopic Dermatitis. [PDF]

Adv Sci (Weinh)
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Li S, Xu D, Zhang C, Xiao C, Yu M, Wang J, Wu W, Lv X, Yuan D, Zhang L, Hong M, Zhou J, Sun Y, Ma H, Zhu Y.   +14 more
europepmc   +2 more sources

Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides

Molecules, 2021
Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects.
Huili Shao, Bingqian Li, Huan Li, Lei Gao, Chao Zhang, Huagang Sheng, Liqiao Zhu   +6 more
doaj   +1 more source

Transcriptome Analysis and Identification of the Cholesterol Side Chain Cleavage Enzyme BbgCYP11A1 From Bufo bufo gargarizans

Frontiers in Genetics, 2022
Bufo bufo gargarizans Cantor are precious medicinal animals in traditional Chinese medicine (TCM). Bufadienolides as the major pharmacological components are generated from the venomous glands of B. bufo gargarizans.
Guangli Li, Tianyue An, Yu Li, Jinyang Yue, Ruoshi Huang, Jia Huang, Jincai Liang, Wei Yao, Liufang Huang, Yidu Chen, Rongrong Zhang, Aijia Ji, Lixin Duan   +12 more
doaj   +1 more source

Insect Collections as an Untapped Source of Bioactive Compounds—Fireflies (Coleoptera: Lampyridae) and Cardiotonic Steroids as a Proof of Concept

Insects, 2021
Natural history collections provide an invaluable basis for systematics, ecology, and conservation. Besides being an important source of DNA, museum specimens may also contain a plethora of natural products. Especially, dried insect collections represent
Andreas Berger, Georg Petschenka, Thomas Degenkolb, Michael Geisthardt, Andreas Vilcinskas   +4 more
doaj   +1 more source

Bufalin-Induced Epithelial-to-Mesenchymal Transition in Kidney Epithelial Cells. [PDF]

Cell Biol Int
ABSTRACT The kidney plays a central role in fluid, electrolyte, and blood pressure regulation, processes tightly coupled to Na⁺/K⁺‐ATPase activity. Beyond its canonical transport function, Na⁺/K⁺‐ATPase also acts as a signaling receptor for cardiotonic steroids (CTSs) such as bufalin, which have been implicated in fibrosis and epithelial‐to‐mesenchymal
Barros GMO, Bagri KM, Mermelstein C, Quintas LEM.   +3 more
europepmc   +2 more sources