Results 21 to 30 of about 2,339 (195)

Resibufogenin and cinobufagin activate central neurons through an ouabain-like action. [PDF]

PLoS ONE, 2014
Cinobufagin and resibufogenin are two major effective bufadienolides of Chan su (toad venom), which is a Chinese medicine obtained from the skin venom gland of toads and is used as a cardiotonic and central nervous system (CNS) respiratory agent, an ...
Ze-Jun Wang, Liqin Sun, Thomas Heinbockel   +2 more
doaj   +1 more source

The Efficacy of Hellebrigenin Against Nasopharyngeal Carcinoma Cells: The Molecular and Bioinformatic Analysis. [PDF]

J Cell Mol Med
ABSTRACT Nasopharyngeal carcinoma (NPC) is a unique cancer type originating from the nasopharynx. To investigate novel strategies for improving prognosis and reducing the adverse effects of current treatments, this study examined the efficacy of hellebrigenin.
Ho HY, Chen MK, Tsai YJ, Lin CC, Lo YS, Chuang YC, Hsieh MJ.   +6 more
europepmc   +2 more sources

Molecular structure-affinity relationship of bufadienolides and human serum albumin in vitro and molecular docking analysis. [PDF]

PLoS ONE, 2015
The development of bufadienolides as anti-tumor agents is limited due to poor pharmacokinetic properties regarding drug half-lives and toxicity in vivo. These serious factors might be improved by increasing the drug/albumin-binding ratio.
Jing Zhou, Guodi Lu, Honglan Wang, Junfeng Zhang, Jinao Duan, Hongyue Ma, Qinan Wu   +6 more
doaj   +1 more source

Tadpole Skin Secretions, Not Food or Temperature, Mediate Costly Cannibal-Induced Plasticity in Invasive Cane Toad Hatchlings. [PDF]

Ecol Evol
Hatchlings of invasive cane toads respond to the risk of cannibalism by accelerating development but experience significant negative carry‐over effects on fitness in the tadpole stage. Our experiments demonstrate that this hatchling response is induced by chemicals located in the skin of older cannibalistic tadpoles. This response is unique to cannibal
Crossland MR, Shine R, DeVore JL.
europepmc   +2 more sources

MALDI-MS argininyl bufadienolide esters fingerprint from parotoid gland secretions of Rhinella arenarum : age, gender and seasonal variation [PDF]

, 2018
In many amphibians, the granular glands can be grouped in special regions forming macroglands. This is the case of toads, characterized by the presence of a pair of parotoid macroglands, strategically located to give protection by poison release in case ...
Erra Balsells, Rosa, Jungblut, Lucas David, Petroselli, Gabriela, Pozzi, Andrea Gabriela, Raices, Marilina   +4 more
core   +1 more source

Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi

Molecules, 2021
Toads in the family Bufonidae contain bufadienolides in their venom, which are characterized by their chemical diversity and high pharmacological potential.
Candelario Rodriguez, Roberto Ibáñez, Luis Mojica, Michelle Ng, Carmenza Spadafora, Armando A. Durant-Archibold, Marcelino Gutiérrez   +6 more
doaj   +1 more source

Antimicrobial activity of skin secretions isolated from Indian toad, Bufo melanostictus Schneider 1799 [PDF]

, 2007
Amphibians like toads have been known to secrete antimicrobial secretions outside their body into their environments, through skin pores and parotid glands.
Abhishek Dinkarnath Garg, Amit N. Gandhare, Dattatrey V. Kanitkar, Rajshekhar V. Hippargi   +3 more
core   +2 more sources

In Vitro Cytotoxicity Induced by the Bufadienolides 1α,2α-Epoxyscillirosidine and Lanceotoxin B on Rat Myocardial and Mouse Neuroblastoma Cell Lines

Toxins, 2019
Consumption of bufadienolide-containing plants are responsible for many livestock mortalities annually. Bufadienolides are divided into two groups; non-cumulative bufadienolides and cumulative bufadienolides.
Danielle Henn, Annette Venter, Christo Botha   +2 more
doaj   +1 more source

The chemistry and biological activity of the Hyacinthaceae [PDF]

, 2013
Covering: 1914 to 2012The Hyacinthaceae (sensu APGII), with approximately 900 species in about 70 genera, can be divided into three main subfamilies, the Hyacinthoideae, the Urgineoideae and the Ornithogaloideae, with a small fourth subfamily the ...
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core   +1 more source

Preparative separation and purification of bufadienolides from ChanSu by high-speed counter-current chromatography combined with preparative HPLC

Química Nova, 2013
Eight bufadienolides were successfully isolated and purified from ChanSu by high-speed counter-current chromatography (HSCCC) combined with preparative HPLC (prep-HPLC).
Jialian Li, Yongqing Zhang, Yunliang Lin, Xiao Wang, Lei Fang, Yanling Geng, Qinde Zhang   +6 more
doaj   +1 more source