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Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]
Neuropharmacology, 2017 There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Philip Hampel +2 more
exaly +3 more sources
Clinical Pharmacology and Therapeutics, 1983
We assessed the response to and handling of furosemide and bumetanide in 30 experiments with the former and 46 with the latter in normal subjects. Oral doses of furosemide (20, 40, and 80 mg) were used, and subjects received oral doses of 0.5, 1, and 2 mg bumetanide and intravenous doses of 0.5 and 1 mg bumetanide.
D C, Brater +4 more
openaire +2 more sources
We assessed the response to and handling of furosemide and bumetanide in 30 experiments with the former and 46 with the latter in normal subjects. Oral doses of furosemide (20, 40, and 80 mg) were used, and subjects received oral doses of 0.5, 1, and 2 mg bumetanide and intravenous doses of 0.5 and 1 mg bumetanide.
D C, Brater +4 more
openaire +2 more sources
Acta Crystallographica Section C Crystal Structure Communications, 1995
The structure of sodium 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoate trihydrate (sodium bumetanide trihydrate), Na + .C 17 H 19 N 2 O 5 S - .3H 2 O, consists of a layer of sodium ions and water molecules between two layers of bumetanide molecules.
SAVIANO M +4 more
openaire +4 more sources
The structure of sodium 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoate trihydrate (sodium bumetanide trihydrate), Na + .C 17 H 19 N 2 O 5 S - .3H 2 O, consists of a layer of sodium ions and water molecules between two layers of bumetanide molecules.
SAVIANO M +4 more
openaire +4 more sources
The Journal of Clinical Pharmacology, 1981
Abstract:The diuretic action of bumetanide was compared with that of furosemide following oral and intravenous administration of equipotent doses in the rat, mouse, cat, rabbit, and dog. The onset of the bumetanide‐induced diuresis was rapid and lasted 4 to 6 hours.
openaire +2 more sources
Abstract:The diuretic action of bumetanide was compared with that of furosemide following oral and intravenous administration of equipotent doses in the rat, mouse, cat, rabbit, and dog. The onset of the bumetanide‐induced diuresis was rapid and lasted 4 to 6 hours.
openaire +2 more sources
The Journal of Clinical Pharmacology, 1981
Abstract: The metabolism of bumetanide is reviewed, with emphasis on the relationship between metabolism and diuretic activity. Substantial evidence has been obtained for the thesis that diuretic activity is dependent on the amount of bumetanide which reaches the renal tubule.
openaire +2 more sources
Abstract: The metabolism of bumetanide is reviewed, with emphasis on the relationship between metabolism and diuretic activity. Substantial evidence has been obtained for the thesis that diuretic activity is dependent on the amount of bumetanide which reaches the renal tubule.
openaire +2 more sources