Results 61 to 70 of about 12,137 (255)

Longitudinal Effects of Bumetanide on Neuro-Cognitive Functioning in Drug-Resistant Epilepsy

Frontiers in Neurology, 2019
Antiepileptic drugs (AEDs) have repeatedly shown inconsistent and almost contradictory effects on the neurocognitive system, from substantial impairments in processing speed to the noticeable improvement in working memory and executive functioning ...
Zeinab Gharaylou, Lida Shafaghi, Mohammad Ali Oghabian, Ali Yoonessi, Abbas Tafakhori, Esmaeil Shahsavand Ananloo, Mahmoudreza Hadjighassem, Mahmoudreza Hadjighassem   +7 more
doaj   +1 more source

Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines [PDF]

, 2014
The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children.
Baiardi, P, Bonifazi, D, Bonifazi, F, Ceci, A, Chiron, C, Davies, E H, Eichler, I, Felisi, M, Giannuzzi, V, Giaquinto, C, Jacqz-Aigrain, E, Neubert, A, on behalf of the GRiP Consortium,, Pressler, R, Rabe, H, Ruggieri, L, Turner, M A, Whitaker, M J   +17 more
core   +1 more source

Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley   +1 more source

A retrospective evaluation of the efficacy of intravenous bumetanide and comparison of potency with furosemide

Pharmacy Practice, 2013
Background: The potency of intravenous bumetanide to furosemide using a ratio of 1:40 has been suggested; however, there are little data supporting this ratio.
Nappi JM
doaj  

Remission during pregnancy of severe Chronic Hypertension due to 11-ß Hydroxylase Deficiency [PDF]

, 2004
When hypertension is a result of an underlying identifiable abnormality, the latter's early discovery can lead to a timely cure of the hypertension and the prevention of its complications.
Attard, Gerhardt, Cachia, Mario J.
core  

The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice [PDF]

, 2018
BACKGROUND: The orphan receptor G protein–coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
Divorty, Nina, Graham, Delyth, Milligan, Graeme, Nicklin, Stuart A.   +3 more
core   +1 more source

Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 220-229, January 2026.
Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu, Hsien‐Chih Chiu, Ju‐Chieh Wung, Yueh‐Ching Chou, Yuh‐Lih Chang, Chian‐Ying Chou, Chin‐Chou Huang   +6 more
wiley   +1 more source

The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme

Pharmaceuticals, 2020
The membrane-bound human carbonic anhydrase (hCA) IX is widely recognized as a marker of tumor hypoxia and a prognostic factor within several human cancers. Being undetected in most normal tissues, hCA-IX implies the pharmacotherapeutic advent of reduced
Azizah M. Malebari, Tarek S. Ibrahim, Ibrahim M. Salem, Ismail Salama, Ahdab N. Khayyat, Samia M. Mostafa, Osama I. El-Sabbagh, Khaled M. Darwish   +7 more
doaj   +1 more source

Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior

Frontiers in Molecular Neuroscience, 2019
Brain trauma triggers a cascade of deleterious events leading to enhanced incidence of drug resistant epilepsies, depression, and cognitive dysfunctions.
Emmanuelle Goubert, Marc Altvater, Marie-Noelle Rovira, Ilgam Khalilov, Ilgam Khalilov, Morgane Mazzarino, Anne Sebastiani, Michael K. E. Schaefer, Claudio Rivera, Claudio Rivera, Christophe Pellegrino   +10 more
doaj   +1 more source

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function

Frontiers in Neurology, 2020
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Ru Liu, Ru Liu, Ru Liu, Ru Liu, Junling Wang, Junling Wang, Junling Wang, Junling Wang, Shuli Liang, Guojun Zhang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang   +13 more
doaj   +1 more source