Results 81 to 90 of about 12,137 (255)

Real‐life implementation of guideline‐recommended medical therapy in heart failure with reduced ejection fraction: Effects on prognosis and left ventricular ejection fraction. Primary results of TITRATE‐HF

European Journal of Heart Failure, Volume 27, Issue 12, Page 2735-2746, December 2025.
Primary results of TITRATE‐HF. GRMT, guideline‐recommended medical therapy; HF, heart failure; HFrEF, heart failure with reduced ejection fraction; LVEF, left ventricular ejection fraction. Abstract Aims Guideline‐recommended medical therapy (GRMT) improves outcomes in heart failure (HF) with reduced ejection fraction (HFrEF), yet implementation ...
Jishnu Malgie, Mariëlle I. Wilde, Stefan Koudstaal, Robert Denham, Carlos A. da Fonseca, Henk P. Swart, Clara E.E. van Ofwegen, Ayten Yilmaz, Ron Pisters, Gerard C.M. Linssen, Nikola Faber, Loek van Heerebeek, Julio E.C. van de Swaluw, Rudolf A. de Boer, Hans‐Peter Brunner‐La Rocca, Jasper J. Brugts   +15 more
wiley   +1 more source

Effect of Co-administration of Bumetanide and Phenobarbital on Seizure Attacks in Temporal Lobe Epilepsy

Basic and Clinical Neuroscience, 2018
Introduction: The resistance of temporal lobe epilepsy to classic drugs is thought to be due to disruption in the excitation/inhibition of this pathway.
Reza Rahmanzadeh, Soraya Mehrabi, Mahmood Barati, Milad Ahmadi, Fereshteh Golab, Sareh Kazmi, Mohammad Taghi Joghataei, Morteza Seifi, Mazaher Gholipourmalekabadi   +8 more
doaj  

Dynamic Functional Network Connectivity Analysis in Autism Spectrum Disorder: An EEG Study

IEEE Access
Convergent evidence has suggested a significant effect of bumetanide exposure on brain connectivity in patients with autism spectrum disorder (ASD), yet the characteristics of favorable treatment outcome remains largely unknown. In this work, we aimed to
Seyedeh Negin Seyed Fakhari, Foad Ghaderi, Mehdi Tehrani-Doost, Nasrollah Moghadam Charkari   +3 more
doaj   +1 more source

Overview of Diuretic Strategies in Edematous States [PDF]

, 2013
Considering potential physiologic causes of volume overload in clinical practice, such as heart failure, renal failure, nephrotic syndrome, or portal hypertension, may yield insight into directing therapy beyond switching from oral to intravenous ...
Mahajan, MD, Kedar
core   +2 more sources

Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease. [PDF]

, 2014
The heterocyclic aldehyde 5-hydroxymethyl-2-furfural (5HMF) interacts allosterically with the abnormal form of haemoglobin (Hb), HbS, in red blood cells (RBCs) from patients with sickle cell disease (SCD), thereby increasing oxygen affinity and ...
Cytlak, Urszula M, Gibson, John S, Hannemann, Anke, Rees, David C, Tewari, Sanjay   +4 more
core   +2 more sources

Clinical profiles and prognostic impact of residual intravascular and tissue congestion in acute heart failure

European Journal of Heart Failure, Volume 27, Issue 12, Page 3123-3133, December 2025.
This study investigated the prognostic value of residual congestion phenotypes at discharge in acute heart failure. Patients with intravascular residual congestion had better diuretic responses and shorter hospital stays than those with tissue/combined residual congestion, but worse outcomes than decongested patients.
Daan C.H. Ceelen, Jozine M. ter Maaten, Geert H.D. Voordes, Gad Cotter, Beth A. Davison, Gerasimos Filippatos, Peter S. Pang, Claudio Gimpelewicz, John G.F. Cleland, G. Michael Felker, Barry Greenberg, Michael M. Givertz, Christopher M. O'Conner, John R. Teerlink, Marco Metra, Adriaan A. Voors   +15 more
wiley   +1 more source

Exploring the Cell Biological and Functional Effects of the First Disease Associated KCC1 Genetic Variant

Journal of Cellular Physiology, Volume 240, Issue 12, December 2025.
ABSTRACT The potassium chloride cotransporter 1 (KCC1) is ubiquitously expressed and essential for regulating cellular fluid balance. We identified a patient carrying a genetic variant (E1065K) in the KCC1 coding gene SLC12A4. This study explored the impact of the variant in ectopic cell systems and enhanced the understanding of cell biological ...
Meye Bloothooft, Jiahui Huang, Mira Hamze, Marien J. C. Houtman, Teun P. de Boer, Peter M. van Hasselt, Gerhard F. Ecker, Christophe Porcher, Igor Medina, Marcel A. G. van der Heyden   +9 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Impact of Wild Edible Fruits of Arbutus unedo and Crataegus monogyna on Gut Motility, Contraction, Secretion, and Glucose Regulation

Neurogastroenterology &Motility, Volume 37, Issue 12, December 2025.
Impact of Wild Edible Fruits of Arbutus unedo and Crataegus monogyna on Gut Motility, Contraction, Secretion, and Glucose Regulation. ABSTRACT Background Arbutus and hawthorn fruits are commonly utilized in traditional medicine to address various gastrointestinal (GI) ailments.
Soumaya Wahabi, Kais Rtibi, Chaima Abidi, Mourad Jridi, Bernard Gressier, Hichem Sebai, Bruno Eto   +6 more
wiley   +1 more source

Repurposed antihypertensive drugs for negative symptoms in schizophrenia: A systematic review and meta‐analysis

Psychiatry and Clinical Neurosciences, Volume 79, Issue 12, Page 784-800, December 2025.
Schizophrenia is a complex psychiatric disorder characterized by positive, negative, and general psychopathological symptoms. While antipsychotic drugs are effective for positive symptoms, they provide limited benefit for negative symptoms, which are often persistent and strongly associated with functional disability.
Thiago Carnaval, My Bui, Jesús Villoria, Dolores Rodríguez, José Manuel Menchón, Francisco Ciruela, Sebastián Videla   +6 more
wiley   +1 more source