Results 81 to 90 of about 6,633 (239)

The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]

, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K, Bowman, Gregory R, Choi, Younho, Frederick, Thomas E, Gross, Michael L, Jung, Jae U, Leung, Daisy W, Shin, Woo-Jin, Wang, Wenjie, Yoo, Ji-Seung, Zhang, Bojie, Zimmerman, Maxwell I   +11 more
core   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

A World of Viruses Nested within Parasites: Unraveling Viral Diversity within Parasitic Flatworms (Platyhelminthes)

Microbiology Spectrum, 2022
Because parasites have an inextricable relationship with their host, they have the potential to serve as viral reservoirs or facilitate virus host shifts.
Nolwenn M. Dheilly, Pierrick Lucas, Yannick Blanchard, Karyna Rosario   +3 more
doaj   +1 more source

Human and murine IFIT1 proteins do not restrict infection of negative-sense RNA viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae families [PDF]

, 2015
UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses.
Amarasinghe, Gaya, Boon, Adrianus C.M., Brien, James D, Diamond, Michael S, Ebihara, Hideki, Liu, Gai, Mühlberger, Elke, Olejnik, Judith, Pinto, Amelia K, Proença-Módena, José Luiz, Szretter, Kristy J, White, James P, Williams, Graham D   +12 more
core   +3 more sources

Multi‐omics analysis reveals discordant proteome and transcriptome responses in larval guts of Frankliniella occidentalis infected with an orthotospovirus

Insect Molecular Biology, Volume 34, Issue 5, Page 671-686, October 2025.
Tomato spotted wilt virus modulated the abundance of gut proteins in larval thrips, most notably manifested as a predominant down‐regulation in first instar larvae. Gut‐expressed protein and cognate transcript abundance were moderately correlated across the tissue system; however, the virus effect varied widely at transcriptional and translational ...
Jinlong Han, Dorith Rotenberg
wiley   +1 more source

Low Thoracic Muscle Mass: A Novel Indicator of Poor Prognosis in Patients With Severe Fever With Thrombocytopenia Syndrome

Immunity, Inflammation and Disease, Volume 13, Issue 9, September 2025.
Low thoracic muscle mass is associated with adverse outcomes in patients with severe fever with thrombocytopenia syndrome. Thoracic muscle mass may serve as a reliable prognostic marker for severe fever with thrombocytopenia syndrome in clinical settings.
Xiao‐Min Wang, Pu Li, Lei Hu, Xiao Zhang, Jun Wang, Cheng‐Xin Zhu, Kun Lv, Da‐Wei Zhang   +7 more
wiley   +1 more source

Isolation of Oropouche Virus from Febrile Patient, Ecuador

Emerging Infectious Diseases, 2018
We report identification of an Oropouche virus strain in a febrile patient from Ecuador by using metagenomic sequencing and real-time reverse transcription PCR. Virus was isolated from patient serum by using Vero cells. Phylogenetic analysis of the whole-
Emma L. Wise, Steven T. Pullan, Sully Márquez, Verónica Paz, Juan D. Mosquera, Sonia Zapata, Simon K. Jackson, Gyorgy Fejer, Gabriel Trueba, Christopher H. Logue   +9 more
doaj   +1 more source

Short‐Term Effects of Meteorological Factors on Severe Fever With Thrombocytopenia Syndrome Incidence in Xinyang, China

GeoHealth, Volume 9, Issue 8, August 2025.
From 1 January 2013 to 31 December 2023 a total of 6,601 cases of SFTS were reported in Xinyang. The incidence of SFTS exhibits evident seasonality, commencing from March and gradually escalating from April, peaking between May and June, followed by a decline with reduced incidence after October.
Quanman Hu, Yan Hu, Yanyan Yang, Jundong Chen, Songshan Zhang, Fei Zhao, Saiwei Lu, Li Zhang, Shuaiyin Chen, Guangcai Duan   +9 more
wiley   +1 more source

Schmallenberg Virus in Domestic Cattle, Belgium, 2012

Emerging Infectious Diseases, 2012
To determine prevalence of antibodies against Schmallenberg virus in adult cows and proportion of infection transmitted to fetuses, we tested serum samples from 519 cow/calf pairs in Belgium in spring 2012.
Mutien-Marie Garigliany, Calixte Bayrou, Déborah Kleijnen, Dominique Cassart, Daniel Desmecht   +4 more
doaj   +1 more source

Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection [PDF]

, 2015
The mosquito-transmitted bunyavirus, Rift Valley fever virus (RVFV), is a highly successful pathogen for which there are no vaccines or therapeutics. Translational arrest is a common antiviral strategy used by hosts.
Cherry, S., Hackett, B. A., Herrmann, C., Hopkins, K. C., Menghani, S. V., Panda, D., Sabin, L. R., Tartell, M. A., Taschuk, F.   +8 more
core   +1 more source