Results 11 to 20 of about 80,732 (295)

Liposomal bupivacaine: a review of a new bupivacaine formulation

open access: yesJournal of Pain Research, 2012
Many attempts have been made to increase the duration of local anesthetic action. One avenue of investigation has focused on encapsulating local anesthetics within carrier molecules to increase their residence time at the site of action. This article aims to review the literature surrounding the recently approved formulation of bupivacaine, which ...
Praveen Chahar
exaly   +6 more sources

Bupivacaine Liposomal versus Bupivacaine: Comparative Review [PDF]

open access: yesHospital Pharmacy, 2014
Bupivacaine liposomal injection was recently approved by the US Food and Drug Administration (FDA) as a local anesthetic for use in management of postsurgical pain in adults. When compared to placebo, bupivacaine liposomal decreases postoperative pain and opioid use.
John Noviasky
exaly   +4 more sources

ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells

open access: yesRedox Biology, 2018
Bupivacaine is frequently administered for diagnosing and controlling spine-related pain in interventional spine procedures. However, the potential cytotoxic effects of bupivacaine on intervertebral disc (IVD) cells and the underlying molecular ...
Yiqiang Hu, Liming Xiong, Xianzhe Liu
exaly   +4 more sources

Chondrotoxicity of Local Anesthetics: Liposomal Bupivacaine Is Less Chondrotoxic than Standard Bupivacaine

open access: yesAdvances in Pharmacological and Pharmaceutical Sciences, 2020
Objective. The purpose of this study is to determine whether (1) liposomal bupivacaine is chondrotoxic; (2) the chondrotoxicity of liposomal bupivacaine differs from standard bupivacaine; and (3) chondrotoxic effects are time dependent.
Travis Farmer   +5 more
doaj   +2 more sources

Direct Vasocontractile Activities of Bupivacaine Enantiomers on the Isolated Rat Thoracic Aorta

open access: yesAnesthesiology Research and Practice, 2010
Background. In vitro studies with isolated arteries have shown direct vasoactivity of racemic bupivacaine. However, there is little information on the direct vasoactivities of bupivacaine enantiomers, S(−)- and R(+)-bupivacaine. Methods.
Mai Mukozawa, Ko Takakura, Maki Mizogami
doaj   +2 more sources

The safety of liposome bupivacaine following various routes of administration in animals

open access: yesJournal of Pain Research, 2015
Girish P Joshi,1 Gary Patou,2 Vladimir Kharitonov21Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical School, Dallas, TX, 2Pacira Pharmaceuticals, Inc., Parsippany, NJ, USABackground: This report presents results ...
Joshi GP, Patou G, Kharitonov V
doaj   +1 more source

Efficacy profile of liposome bupivacaine, a novel formulation of bupivacaine for postsurgical analgesia

open access: yesJournal of Pain Research, 2012
Sergio D Bergese1, Sonia Ramamoorthy2, Gary Patou3, Kenneth Bramlett4, Stephen R Gorfine5, Keith A Candiotti61Department of Anesthesiology and Neurological Surgery, Ohio State University, Columbus, OH, USA; 2Department of Surgery, University of ...
Candiotti KA   +5 more
doaj   +1 more source

Comparison of pain with bupivacaine and bupivacaine-sufentanil combination in women undergoing cesarean section with spinal anesthesia: A double-blind randomized clinical trial [PDF]

open access: yesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2022
Introduction: Today, spinal anesthesia is the method of choice for most cesarean sections. Postoperative pain control has always been one of the main concerns of anesthesiologists.
Hasan Zabetian   +3 more
doaj   +1 more source

Clinical evaluation of epidural bupivacaine, butorphanol, and butorphanol - bupivacaine combination in goat [PDF]

open access: yesJournal of Veterinary Medical Research, 2019
0px; "> Butorphanol is a synthetic opioid commonly used for epidural anesthesia in humaneither alone or in combination with bupivacaine but not in goat.
Hagag U., Mahmoud M.M.
doaj   +3 more sources

The Local Anesthetic Bupivacaine Inhibits the Progression of Non-Small Cell Lung Cancer by Inducing Autophagy Through Akt/mTOR Signaling

open access: yesFrontiers in Oncology, 2021
Non-small cell lung cancer (NSCLC) is a prevalent malignancy with high mortality and poor prognosis. Bupivacaine serves as a widely used local anesthetic and presents potential anti-tumor activity.
Jian-Hua Gu   +6 more
doaj   +1 more source

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