Results 231 to 240 of about 43,211 (293)

Control of action potential afterdepolarizations in the inferior olive by inactivating A‐type currents through KV4 channels

The Journal of Physiology, EarlyView.
Abstract figure legend KV4 channel availability regulates inferior olive action potential duration. The durations of action potentials in inferior olive neurons (blue) depend strongly on preceding membrane potential, with afterdepolarizations varying over the physiological range by almost two orders of magnitude (open circles). Voltage clamp recordings
Ziyad W. Sultan, Marion Najac, Indira M. Raman   +2 more
wiley   +1 more source

Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury

The Journal of Physiology, EarlyView.
Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular junctions (NMJ). A full thickness model of VML injury to the tibialis anterior muscle of adult Lewis rats was used, and treatments included Herceptin, a ...
Jacob R. Sorensen, Daniel B. Hoffman, Christiana J. Raymond‐Pope, Thomas J. Lillquist, Amanda M. Russell, Benjamin T. Corona, Sarah M. Greising   +6 more
wiley   +1 more source

What Is Your Diagnosis? Fine‐Needle Aspirate From a Lingual Mass in a Cat

Veterinary Clinical Pathology, EarlyView.
Emma Stacey, Andrii Trokoz, Kimberly Williams, Dorothee Bienzle   +3 more
wiley   +1 more source

KCC2 enhancers normalize reflex responses and improve locomotor function after chronic spinal cord injury

The Journal of Physiology, EarlyView.
Abstract figure legend In the intact spinal cord, KCC2 maintains chloride homeostasis, ensuring effective GABAergic inhibition required for normal reflexes and locomotor control (left). Following spinal cord injury, KCC2 is downregulated, weakening inhibitory signaling and leading to dysregulated reflex activity and impaired locomotion (middle ...
Jadwiga N. Bilchak, Simon M. Danner, Guillaume Caron, Marie‐Pascale Côté   +3 more
wiley   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Contusive spinal cord injury causes Nav1.8 dysfunction to upregulate small sensory neuron excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Contusive SCI significantly dysregulated excitability of small DRG neurons by enhancing Nav1.8 function. SCI‐induced hyperexcitability was partially reversed by ZL0177, a small compound disrupting FHF interaction with Nav1.8 and Nav1.9.
Yucheng Xiao, Yanling Pan, Naikui Liu, Theodore R. Cummins   +3 more
wiley   +1 more source

Pharmacokinetics of Buprenorphine Hydrochloride (BN HCl). (2): Role of Stratum Corneum in Percutaneous Absorption of TSN-09 (BN HCl containing tape) in Male Rats.

, 2001
Yasuhiro Takahashi, Shigeyuki Ishii, H Arizono, Shinichi Nishimura, Noriyuki Saito, Hiroyuki Nemoto, Kenji Yoshida, Yoshio ESUMI   +7 more
openalex   +2 more sources

National consensus statement on opioid agonist treatment in custodial settings

Medical Journal of Australia, Volume 222, Issue 5, Page 262-268, March 2025.
Abstract Introduction Opioid use and dependence are prevalent among incarcerated people, contributing to elevated rates of overdose and other harms in this population. Opioid agonist treatment (OAT) has been shown to be an effective intervention to mitigate these risks. However, challenges to health care implementation in the custodial sector result in
Jocelyn Chan, Jon Cook, Michael Curtis, Adrian J Dunlop, Ele Morrison, Suzanne Nielsen, Rebecca J Winter, Thileepan Naren   +7 more
wiley   +1 more source

Buprenorphine: An Analgesic with an Expanding Role in the Treatment of Opioid Addiction

, 2002
Susan Robinson
openalex   +1 more source

Healthcare Practitioner and Other Professionals' Perspectives on Gabapentinoid Misuse and Dependence: A Systematic Review of Qualitative Studies

European Journal of Pain, Volume 29, Issue 9, October 2025.
ABSTRACT Background and Objective The global rise in gabapentinoid prescriptions for chronic pain has been striking. However, this trend has been accompanied by growing concerns about misuse and dependence. This qualitative systematic review aimed to synthesise the perspectives of healthcare practitioners and other professionals on these emerging ...
Amy G. McNeilage, Evan Browne, Suzanne Nielsen, Claire E. Ashton‐James, Bridin Murnion   +4 more
wiley   +1 more source