Critical evaluation of real-world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation. [PDF]
Alzheimers Dement (N Y)Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Tonegawa-Kuji R +10 more
europepmc +2 more sources
Bupropion perceived as a stimulant by two patients with a previous history of cocaine misuse
Annali dell'Istituto Superiore di Sanità, 2013 BACKGROUND AND OBJECTIVE: Despite animal studies having shown a generalisation of the bupropion cue to cocaine, this drug has been used in cocaine abuse with mixed results. We here aimed at describing two cases which contradict current knowledge.
Alessandro E. Vento +6 more
doaj +1 more source
Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS [PDF]
, 2016 Bupropion metabolites formed via oxidation and reduction exhibit pharmacological activity, but little is known regarding their stereoselective disposition.
Desta, Zeruesenay +3 more
core +1 more source
Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones [PDF]
, 2017 Synthetic cathinones are a new class of psychostimulant substances. Rarely, they can cause liver injury but associated mechanisms are not completely elucidated.
Krähenbühl, Stephan +2 more
core +1 more source
Effectiveness of bupropion on sexual dysfunction of women with multiple sclerosis: A Clinical Trial [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2021 Introduction: Sexual dysfunctions are relatively prevalent in female patients with multiple sclerosis (MS) and affect their quality of life. This study was performed with aim to evaluate the effect of Bupropion on sexual function in women with multiple ...
Farzaneh Yavari +7 more
doaj +1 more source
Bupropion administration increases resting-state functional connectivity in dorso-medial prefrontal cortex [PDF]
, 2017 Background: Patients on the selective serotonergic re-uptake inhibitors (SSRI) like citalopram report emotional blunting. We have shown previously that citalopram reduces resting-state functional connectivity (RSFC) in healthy volunteers in a number of ...
Dean, Zola +2 more
core +1 more source
Archives of Epilepsy, 2018 Bupropion inhibits reuptakes of dopamine and noradrenaline. Since it is also a nicotine receptor antagonist, it acts as a drug used for smoking cessation. Bupropion is commonly preferred because of no side effects on weight, sexual function, and the lack
Zeynep ÖZÖZEN AYAS +1 more
doaj +1 more source
Annals of General Psychiatry, 2008 Background Bupropion HCl is a widely used antidepressant that is known to cause seizures in a dose-dependent manner. Many patients taking antidepressants will consume alcohol, even when advised not to.
Fleming Rosanna +4 more
doaj +1 more source
General Practitioners' views on the provision of nicotine replacement therapy and bupropion. [PDF]
, 2001 BACKGROUND: Nicotine replacement therapies (NRT) and a new drug, bupropion, are licensed in several countries as aids to smoking cessation. General practitioners (GPs) play a crucial role in recommending or prescribing these medications.
A McEwen +21 more
core +3 more sources
Efficacy and safety of pharmacotherapies for smoking cessation in anxiety disorders: Subgroup analysis of the randomized, active- and placebo-controlled EAGLES trial. [PDF]
, 2020 BackgroundSmoking rates are high in adults with anxiety disorders (ADs), yet little is known about the safety and efficacy of smoking-cessation pharmacotherapies in this group.MethodsPost hoc analyses in 712 smokers with AD (posttraumatic stress disorder
Anthenelli, Robert M +6 more
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