Results 41 to 50 of about 5,575 (204)

Burkholderia Vaccines: Are We Moving Forward?

Frontiers in Cellular and Infection Microbiology, 2013
The genus Burkholderia consists of diverse species which includes both ‘friends’ and ‘foes’. Some of the ‘friendly’ Burkholderia spp. are extensively used in the biotechnological and agricultural industry for bioremediation and biocontrol.
Leang-Chung eChoh, Guang-Han eOng, Kumutha Malar Vellasamy, Kaveena eKalaiselvam, Wen-Tyng eKang, Anis Rageh Al-Maleki, Vanitha eMariappan, Jamuna eVadivelu   +7 more
doaj   +1 more source

Continuing evolution of Burkholderia mallei through genome reduction and large-scale rearrangements [PDF]

, 2010
Burkholderia mallei (Bm), the causative agent of the predominately equine disease glanders, is a genetically uniform species that is very closely related to the much more diverse species Burkholderia pseudomallei (Bp), an opportunistic human pathogen and
Badger, Jonathan, Beckstrom-Sternberg, Stephen M., Brinkac, Lauren, Crabtree, Jonathan, DeShazer, David, Fedorova, Natalie, Keim, Paul, Kim, H. Stanley, Losada, Liliana, Nandi, Tannistha, Nierman, William C., Pearson, Talima R., Ronning, Catherine M., Saqib, Muhammad, Schutzer, Steven E., Shabalina, Svetlana A., Tan, Patrick, Woods, Donald   +17 more
core   +2 more sources

<i>Burkholderia pseudomallei</i> in Colombia: Laboratory Approaches to Enhance Diagnostic Accuracy. [PDF]

Int J Microbiol
Background Melioidosis is a challenging disease to diagnose, and diagnostic complications can delay treatment, adversely impacting patient outcomes. Methods Over a period of 1 year, 68 isolates, initially identified as Burkholderia spp. or oxidase‐positive nonfermenting Gram‐negative bacilli (excluding Pseudomonas aeruginosa), were collected from ...
Morales-Lopez S, Villero Wolf Y, Lechuga D, Caicedo L, Acosta Triana Y, Gomez L, Ramirez LR, Narvaez L, Pinzon H, Esquea K, Barros R, Martinez Ramos P, Marin A, Parra CM.   +13 more
europepmc   +2 more sources

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species [PDF]

, 2017
Burkholderia is a genus within the β-Proteobacteriaceae that contains at least 90 validly named species which can be found in a diverse range of environments. A number of pathogenic species occur within the genus.
Butt, A.T., Thomas, M.S.
core   +7 more sources

Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic Burkholderia spp

mSphere, 2019
Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. There is no vaccine to protect against these highly pathogenic bacteria, and there is concern regarding their emergence as global public
Robert J. Hogan, Eric R. Lafontaine
doaj   +1 more source

Strategies toward vaccines againstBurkholderia malleiandBurkholderia pseudomallei [PDF]

Expert Review of Vaccines, 2008
Burkholderia mallei and Burkholderia pseudomallei are Gram-negative, rod-shaped bacteria, and are the causative agents of the diseases glanders and melioidosis, respectively. These bacteria have been recognized as important pathogens for over 100 years, yet a relative dearth of available information exists regarding their virulence determinants and ...
Sara K, Bondi, Joanna B, Goldberg
openaire   +2 more sources

Detection and differentiation of Burkholderia species with pathogenic potential in environmental soil samples.

PLoS ONE, 2021
The Burkholderia pseudomallei phylogenetic cluster includes B. pseudomallei, B. mallei, B. thailandensis, B. oklahomensis, B. humptydooensis and B. singularis. Regarded as the only pathogenic members of this group, B. pseudomallei and B. mallei cause the
Sujintana Janesomboon, Veerachat Muangsombut, Varintip Srinon, Chatruthai Meethai, Chayada S Tharinjaroen, Premjit Amornchai, Patoo Withatanung, Narisara Chantratita, Mark Mayo, Vanaporn Wuthiekanun, Bart J Currie, Joanne M Stevens, Sunee Korbsrisate   +12 more
doaj   +1 more source

Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells [PDF]

, 2015
Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp.
Graeme C. Clark, Jonathan David, Rachel E. Bell   +2 more
core   +1 more source

Structural flexibility in the Burkholderia mallei genome [PDF]

Proceedings of the National Academy of Sciences, 2004
The complete genome sequence of Burkholderia mallei ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history. B. mallei , the etiologic agent of glanders, has come under renewed scientific investigation ...
William C, Nierman, David, DeShazer, H Stanley, Kim, Herve, Tettelin, Karen E, Nelson, Tamara, Feldblyum, Ricky L, Ulrich, Catherine M, Ronning, Lauren M, Brinkac, Sean C, Daugherty, Tanja D, Davidsen, Robert T, Deboy, George, Dimitrov, Robert J, Dodson, A Scott, Durkin, Michelle L, Gwinn, Daniel H, Haft, Hoda, Khouri, James F, Kolonay, Ramana, Madupu, Yasmin, Mohammoud, William C, Nelson, Diana, Radune, Claudia M, Romero, Saul, Sarria, Jeremy, Selengut, Christine, Shamblin, Steven A, Sullivan, Owen, White, Yan, Yu, Nikhat, Zafar, Liwei, Zhou, Claire M, Fraser   +32 more
openaire   +2 more sources