Results 41 to 50 of about 5,430 (204)

Comparison of TaqMan PCR assays for detection of the melioidosis agent Burkholderia pseudomallei in clinical specimens [PDF]

, 2012
Melioidosis is an emerging infectious disease caused by the soil bacterium Burkholderia pseudomallei. In diagnostic and forensic settings, molecular detection assays need not only high sensitivity with low limits of detection but also high specificity ...
Bowers, Jolene, Colman, Rebecca, Currie, Bart J., Engelthaler, David M., Kaestli, Mirjam E., Keim, Paul S., Kelley, Erin, Mayo, Mark J., Pearson, Talima, Price, Erin P., Richardson, Leisha J., Sarovich, Derek, Schupp, James, Seymour, Meagan, Tuanyok, Apichai, Wagner, David M.   +15 more
core   +4 more sources

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

Continuing evolution of Burkholderia mallei through genome reduction and large-scale rearrangements [PDF]

, 2010
Burkholderia mallei (Bm), the causative agent of the predominately equine disease glanders, is a genetically uniform species that is very closely related to the much more diverse species Burkholderia pseudomallei (Bp), an opportunistic human pathogen and
Badger, Jonathan, Beckstrom-Sternberg, Stephen M., Brinkac, Lauren, Crabtree, Jonathan, DeShazer, David, Fedorova, Natalie, Keim, Paul, Kim, H. Stanley, Losada, Liliana, Nandi, Tannistha, Nierman, William C., Pearson, Talima R., Ronning, Catherine M., Saqib, Muhammad, Schutzer, Steven E., Shabalina, Svetlana A., Tan, Patrick, Woods, Donald   +17 more
core   +2 more sources

Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic Burkholderia spp

mSphere, 2019
Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. There is no vaccine to protect against these highly pathogenic bacteria, and there is concern regarding their emergence as global public
Robert J. Hogan, Eric R. Lafontaine
doaj   +1 more source

In vivo bioluminescence imaging of Burkholderia mallei respiratory infection and treatment in the mouse model [PDF]

, 2011
Bioluminescent imaging (BLI) technology is a powerful tool for monitoring infectious disease progression and treatment approaches. BLI is particularly useful for tracking fastidious intracellular pathogens that might be difficult to recover from certain ...
Shane eMassey, Katie eJohnston, Tiffany M Mott, Barbara M Judy, Brian H Kvitko, Herbert P Schweizer, D Mark Estes, Alfredo G Torres   +7 more
core   +1 more source

Strategies toward vaccines againstBurkholderia malleiandBurkholderia pseudomallei [PDF]

Expert Review of Vaccines, 2008
Burkholderia mallei and Burkholderia pseudomallei are Gram-negative, rod-shaped bacteria, and are the causative agents of the diseases glanders and melioidosis, respectively. These bacteria have been recognized as important pathogens for over 100 years, yet a relative dearth of available information exists regarding their virulence determinants and ...
Sara K, Bondi, Joanna B, Goldberg
openaire   +2 more sources

Detection and differentiation of Burkholderia species with pathogenic potential in environmental soil samples.

PLoS ONE, 2021
The Burkholderia pseudomallei phylogenetic cluster includes B. pseudomallei, B. mallei, B. thailandensis, B. oklahomensis, B. humptydooensis and B. singularis. Regarded as the only pathogenic members of this group, B. pseudomallei and B. mallei cause the
Sujintana Janesomboon, Veerachat Muangsombut, Varintip Srinon, Chatruthai Meethai, Chayada S Tharinjaroen, Premjit Amornchai, Patoo Withatanung, Narisara Chantratita, Mark Mayo, Vanaporn Wuthiekanun, Bart J Currie, Joanne M Stevens, Sunee Korbsrisate   +12 more
doaj   +1 more source

Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells [PDF]

, 2015
Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp.
Graeme C. Clark, Jonathan David, Rachel E. Bell   +2 more
core   +1 more source

Structural flexibility in the Burkholderia mallei genome [PDF]

Proceedings of the National Academy of Sciences, 2004
The complete genome sequence of Burkholderia mallei ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history. B. mallei , the etiologic agent of glanders, has come under renewed scientific investigation ...
William C, Nierman, David, DeShazer, H Stanley, Kim, Herve, Tettelin, Karen E, Nelson, Tamara, Feldblyum, Ricky L, Ulrich, Catherine M, Ronning, Lauren M, Brinkac, Sean C, Daugherty, Tanja D, Davidsen, Robert T, Deboy, George, Dimitrov, Robert J, Dodson, A Scott, Durkin, Michelle L, Gwinn, Daniel H, Haft, Hoda, Khouri, James F, Kolonay, Ramana, Madupu, Yasmin, Mohammoud, William C, Nelson, Diana, Radune, Claudia M, Romero, Saul, Sarria, Jeremy, Selengut, Christine, Shamblin, Steven A, Sullivan, Owen, White, Yan, Yu, Nikhat, Zafar, Liwei, Zhou, Claire M, Fraser   +32 more
openaire   +2 more sources

Thiotemplated Polyketide Chain Fusion and Reductive Cyclization Build the Reactive Butenolide Core of Malleicyprol

Angewandte Chemie, Volume 137, Issue 31, July 28, 2025.
Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, results from the fusion of two individual polyketide chains. The noncanonical condensation domain of the PKS–NRPS hybrid synthetase BurF forms an ester bond, and the terminal reductase domain mediates a reductive chain release followed ...
Jonas Fiedler, Leo Dumjahn, Mie Ishida‐Ito, Felix Trottmann, Keishi Ishida, Christian Hertweck   +5 more
wiley   +2 more sources