Results 71 to 80 of about 18,506 (177)
Modélisation Pharmacocinétique et Pharmacodynamique du Busulfan en Onco-Hématologie Pédiatrique [PDF]
, 2017 Hematopoietic stem cell transplantation remains the only curative treatment in many pediatric diseases as leukemia, sarcoma, immunodeficiencies or thalassemia. Busulfan, a myeloablative alkylant, is the cornerstone of pre-transplant conditioning.
Philippe, Michaël
core +1 more source
The Journal of Poultry Science, 2009 The current study aimed to determine the optimal time of busulfan (1,4-butanediol dimethanesulfonate) administration for the preparation of suitable recipient embryos to generate germline chimeras in chickens.
Yoshiaki Nakamura +9 more
doaj +1 more source
The role of iron in normal and impaired testicular function
Andrology, EarlyView.Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer +2 more
wiley +1 more source
Busulfan in Hematopoietic Stem Cell Transplantation [PDF]
, 2009 The development of intravenous busulfan (Bu) and its incorporation in the preparative regimens for allogeneic stem cell transplantation has changed transplantation for myelogenous malignancies.
Andersson, Borje S., Ciurea, Stefan O.
core +1 more source
British Journal of Haematology, EarlyView.Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo +3 more
wiley +1 more source
فصلنامه دانشگاه علوم پزشکی جهرم, 2015 Background & Objective: The spermatogenesis is a complicated process which different factors affect it and lead the infertility or fertility reduction.
Khaton rezai +2 more
doaj
British Journal of Haematology, EarlyView.Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi +3 more
wiley +1 more source
Haematologica, 2014 Busulfan liver metabolism depends on glutathione, a crucial mediator of cellular and systemic stress. Here we investigated 40 polymorphisms at 27 loci involved in hepatic glutathione homeostasis, with the aim of testing their impact on the clinical ...
Francesca Bonifazi +17 more
doaj +1 more source
British Journal of Haematology, EarlyView.In patients with essential thrombocythaemia or polycythaemia vera, higher estimated pulse wave velocity (ePWV) was independently associated with major adverse cardiovascular events, while its relationship with overall survival was largely age‐driven.
Alessandro Costa +6 more
wiley +1 more source
, 2022 Aims: The aims of the study were to 1) establish a population pharmacokinetic (Pop-PK) model for busulfan in Chinese pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and then estimate busulfan exposure and 2) explore the ...
Yiduo Ding (12879719) +17 more
core +1 more source