Results 121 to 130 of about 6,620 (168)

Schedule dependence of buthionine sulfoximine in reversing resistance to cisplatin

Chemico-Biological Interactions, 1990
We have found that the potentiation of antiproliferative effects by buthionine sulfoximine (BSO) of cell growth inhibition induced by cisplatin are highly schedule dependent in resistant BE colon carcinoma cells. Maintenance of low GSH levels during the 12-h interval after cisplatin (cis-DDP) treatment is critical.
N J, Robichaud, R J, Fram
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Buthionine Sulfoximine Treatment Impairs Rat Diaphragm Function

American journal of respiratory and critical care medicine, 1994
Abstract Activation of the glutathione (GSH) redox cycle with production of glutathione disulfide (GSSG) has been shown to occur in the diaphragm during inspiratory resistive loading (RB). Buthionine sulfoximine (BSO) lowers tissue GSH by irreversibly inhibiting the rate-limiting synthesis enzyme gamma-glutamylcysteine synthetase.
C F, Morales, A, Anzueto, F, Andrade, J, Brassard, S M, Levine, L C, Maxwell, R A, Lawrence, S G, Jenkinson   +7 more
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Inhibition of glutathione synthesis of Ascaris suum by buthionine sulfoximine

Parasitology Research, 1996
We investigated the effect of DL-buthionine-S,R-sulfoximine (BSO), a selective glutathione (GSH)-depleting agent, on the GSH synthesis of Ascaris suum. The GSH concentrations of the reproductive and muscle tissues of A. suum were determined to be 8.5 +/- 0.3 and 14.3 +/- 1.3 (n = 3) nmol/mg protein, respectively.
A S, Hussein, R D, Walter
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Enhancement of the depigmenting effect of hydroquinone by cystamine and buthionine sulfoximine

British Journal of Dermatology, 1995
Glutathione (GSH) performs several important biological functions, including quenching of reactive oxygen species, and protection of cells from toxic compounds such as quinones. The first step in the synthesis of GSH is catalysed by gamma-glutamylcysteine synthetase, an enzyme which is inhibited by cystamine and buthionine sulfoximine (BSO).
J L, Bolognia, S A, Sodi, M P, Osber, J M, Pawelek   +3 more
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The effect of in utero administration of buthionine sulfoximine on rat development

Pharmacology Biochemistry and Behavior, 1995
Glutathione (GSH) is a tripeptide that is thought to be an essential cell component playing an important role as a cellular antioxidant and scavenger of free radicals. GSH depletion has been shown to render cells more sensitive to various insults. GSH has a protective effect.
E, Reyes, S, Ott, B, Robinson, R, Contreras   +3 more
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Depletion of Brain Glutathione in Preweanling Mice by L-Buthionine Sulfoximine

Journal of Neurochemistry, 1988
Abstract: Previous studies indicated that DL‐buthionine sulfoximine (dl‐BSO), an agent that inhibits the biosynthesis of GSH in liver and other peripheral organs, fails to suppress levels of GSH in the CNS. In the current study, preweanling mice responded to repeated injections of l‐BSO with marked declines (79.6–86.5%) of GSH content in brain and ...
H I Calvin, A Slivka, Gerald Cohen
exaly   +3 more sources

Plasma glutathione turnover in the rat: effect of fasting and buthionine sulfoximine

Canadian Journal of Physiology and Pharmacology, 1991
Hepatic glutathione (GSH) plays an important role in the detoxification of reactive molecular intermediates. Because of evidence that the intrahepatic turnover of glutathione in the rat may be largely accounted for by efflux from hepatocytes into the general circulation, the quantitation of plasma GSH turnover in vivo could provide a noninvasive index
S, Hum, L, Robitaille, L J, Hoffer
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Effects of buthionine sulfoximine on the development of ozone-induced pulmonary fibrosis

Experimental and Molecular Pathology, 1988
The capacity of reduced glutathione (GSH) to protect lung tissue against ozone-induced pulmonary fibrosis was investigated. Male B6C3F1 mice were exposed to 0, 0.2, 0.5, and 1.0 ppm ozone for 23 hr/day for 14 days. During exposures and/or for a period of 90 days after exposures, subgroups of mice at each exposure level were given drinking water ...
J D, Sun, J A, Pickrell, J R, Harkema, S I, McLaughlin, F F, Hahn, R F, Henderson   +5 more
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Effects of phorone and/or buthionine sulfoximine on teratogenicity of 5‐fluorouracil in mice

Teratology, 1990
AbstractEmbryotoxicity and teratogenicity of 5‐fluorouracil (5‐FU) and modulation of its effect by the depletors of glutathione (GSH) were evaluated in mice. Pregnant ICR mice were intraperitoneally (i.p.) injected with 25 mg/kg of 5‐FU on day 11 of gestation (vaginal plug = day 0). Mice were pretreated i.p.
M, Naya, Y, Mataki, H, Takahira, T, Deguchi, M, Yasuda   +4 more
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Buthionine sulfoximine-induced cytostasis does not correlate with glutathione depletion

American Journal of Physiology-Cell Physiology, 1992
The effects of L-buthionine-(S,R)-sulfoximine (BSO) on the proliferation of normal rat kidney fibroblasts (NRK-49F) were determined and compared with the effects of BSO on cellular glutathione (GSH) content. The proliferation rate of exponentially growing NRK-49F cells was found to be slowed in 0.01 and 0.1 mM BSO and arrested in 1.0 and 10 mM BSO ...
Y J, Kang, M D, Enger
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