Results 131 to 140 of about 6,620 (168)
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Hearing Research, 1999
The aim of this experiment was to determine if buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis, enhances the ototoxicity of carboplatin. Osmotic pumps were used to infuse BSO into the right cochleas of 12 adult chinchillas for 14 days. The left cochleas served as controls.
B H, Hu +3 more
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The aim of this experiment was to determine if buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis, enhances the ototoxicity of carboplatin. Osmotic pumps were used to infuse BSO into the right cochleas of 12 adult chinchillas for 14 days. The left cochleas served as controls.
B H, Hu +3 more
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Buthionine sulfoximine causes endothelium dependent hyper-relaxation and hypoadiponectinemia
Life Sciences, 2007A close relationship between oxidative stress, endothelial dysfunction, and hypoadiponectinemia has been observed. The present study was performed to investigate how glutathione depletion via buthionine sulfoximine (BSO) administration affects endothelial function and adiponectin levels in rats.
Chigusa, Iwata +4 more
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Improved use of buthionine sulfoximine to prevent cisplatin nephrotoxicity in rats
Journal of Cancer Research and Clinical Oncology, 1989Male Sprague Dawley rats were treated with buthionine sulfoximine (BSO) and cisplatin in different doses and schedules to optimize the chemoprotective effect of BSO against cisplatin nephrotoxicity. BSO at 4 mmol/kg, administered s.c. 2 h prior to cisplatin, resulted in normal blood urea nitrogen (BUN) levels in rats treated with 3 or 4 mg/kg cisplatin,
R D, Mayer, K E, Lee, A T, Cockett
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Toxicology Letters, 1987
Pretreatment with buthionine sulfoximine (BSO; 900 mg/kg) induced the elevation of serum GOT and GPT activities in a non-toxic dose of butylated hydroxytoluene (BHT; 250-500 mg/kg) in rats. The elevation of serum enzyme activities was accompanied by a remarked depletion of the hepatic glutathione (GSH) concentration.
Yoshio Nakagawa
exaly +3 more sources
Pretreatment with buthionine sulfoximine (BSO; 900 mg/kg) induced the elevation of serum GOT and GPT activities in a non-toxic dose of butylated hydroxytoluene (BHT; 250-500 mg/kg) in rats. The elevation of serum enzyme activities was accompanied by a remarked depletion of the hepatic glutathione (GSH) concentration.
Yoshio Nakagawa
exaly +3 more sources
Exogenous glutathione attenuates the antiproliferative effect of buthionine sulfoximine
Toxicology, 1994Buthionine sulfoximine (BSO) inhibits proliferation of human lung carcinoma A549 cells in a manner that does not correlate with intracellular glutathione (GSH) depletion, nor does it reflect overt toxic effects of BSO. However, BSO inhibits uptake by A549 cells of cystine, which is an essential amino acid for cell growth in culture.
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Inhibition of the protective effect of cyclophosphamide by pre-treatment with buthionine sulfoximine
International Journal of Radiation Oncology*Biology*Physics, 1986Low dose cyclophosphamide (CTX) is protective against a subsequent challenge with a lethal dose of the same drug administered 5 days later. At the time of maximal protection, elevation of glutathione (GSH) and glutathione transferase (GST) levels are detectable in the bone marrow of pre-treated animals.
Carmichael, James +6 more
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Antifungal and aflatoxigenic activity of buthionine sulfoximine
2012Antifungal and antiaflatoxigenic effects of buthionine sulfoximine (BSO) were investigated against Aspergillus flavus NRRL 3251 on glucose minimum salts (GMS) microbiological medium. Butathionine sulfoximine is known inhibitor of glutathione S-transferase (GST), and GST is suspected to have transporter function in aflatoxin biosynthesis.
Šarkanj, Bojan +3 more
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Protection from hyperbaric oxidant stress by administration of buthionine sulfoximine
Journal of Applied Physiology, 1991To explore the role of glutathione in protecting rats from hyperbaric hyperoxia, we administered buthionine sulfoximine (BSO) to block gamma-glutamyl cysteine synthase activity and decrease tissue glutathione synthesis. We then exposed these animals and their vehicle-treated matched controls to 100% oxygen at 4 ATA or room air at 1 ATA.
K H, Komadina +3 more
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The Pulmonary Effects of Buthionine Sulfoximine Treatment and Glutathione Depletion in Rats
American Review of Respiratory Disease, 1988Abstract Buthionine sulfoximine (BSO), an inhibitor of de novo synthesis of glutathione (GSH), was used to deplete rats of GSH and determine the effect of treatment on antioxidant enzyme responses, lung injury, and the susceptibility to concurrent sublethal or lethal hyperoxia.
D B, Coursin, H P, Cihla
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Buthionine sulfoximine embryotoxicity is associated with prolonged AP‐1 activation
Teratology, 2002AbstractBackgroundMany teratogens induce oxidative stress, altering redox status and redox signaling; this has led to the suggestion that developmental toxicants act by disturbing redox status. The goal of these studies was to determine the consequences of altering glutathione homeostasis during organogenesis on embryo development, total DNA ...
Terence R S, Ozolins +4 more
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