Results 141 to 150 of about 6,620 (168)

Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine

Toxicology, 2011
Gender is a factor that influences susceptibility of individuals to drug-induced liver injury in experimental animals and humans. In this study, we investigated the mechanisms underlying resistance of female mice to acetaminophen (APAP)-induced hepatotoxicity. Overnight-fasted male and female CD-1 mice were administered APAP intraperitoneally.
Yasuhiro, Masubuchi, Junpei, Nakayama, Yasuko, Watanabe   +2 more
openaire   +2 more sources

Enhancement of melphalan activity by buthionine sulfoximine and electroporation in melanoma cells

Anti-Cancer Drugs, 2015
Melphalan represents the reference drug for locoregional chemotherapy of melanoma; nevertheless, treatment failure may occur because of resistance to chemotherapy. Refractory melanoma cells show either an increased capability of drug inactivation, which is known to be associated with elevated intracellular levels of glutathione (GSH), or a decreased ...
ONGARO, Alessia, PELLATI, Agnese, DE MATTEI, Monica, Francesca De Terlizzi, Carlo Riccardo Rossi, Luca Giovanni Campana   +5 more
openaire   +4 more sources

Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine

Cancer Chemotherapy and Pharmacology, 1991
Melphalan-induced toxicity in nude mice following pretreatment with a regimen of L-buthionine sulfoximine (BSO), previously shown to enhance the activity of this alkylating agent against rhabdomyosarcoma and glioma xenografts, was examined. Mice were pretreated with i.p. BSO (2.5 mmol/kg x 7 doses at 12-h intervals plus concomitant availability of a 20-
S X, Skapek, A F, VanDellen, D P, McMahon, D G, Postels, O W, Griffith, D D, Bigner, H S, Friedman   +6 more
openaire   +2 more sources

Glutathione Depletion with Buthionine Sulfoximine: Potential Clinical Applications

1986
The effectiveness of chemotherapy in the treatment of many tumors is limited by two clinically distinct types of drug resistance. Tumors such as colon cancer, non-small lung cancer and malignant melanoma are inherently resistant to chemotherapy and response rates in these patients are low.
Robert F. Ozols, Thomas C. Hamilton, Karen G. Louie, Brent C. Behrens, Robert C. Young   +4 more
openaire   +1 more source

Buthionine sulfoximine-induced glutathione depletion

Biochemical Pharmacology, 1995
Jacob Thanislass, Muthuswamy Raveendran, Halagowder Devaraj   +2 more
openaire   +1 more source

The effect of buthionine sulfoximine on the glutathione level in goldfish tissues.

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2006
This study describes the effect of DL-buthionine-[S,R]-sulfoximine (BSO) on the glutathione equivalents (GSH-eq = GSH + 2 GSSG) of goldfish. BSO causes depletion of cellular GSH by inhibiting gamma-glutamylcysteine synthetase, a key enzyme of the GSH biosynthesis pathway.
V I, Lushchak, M, Hermes-Lima
openaire   +1 more source

Buthionine Sulfoximine

2007
S.J. Enna, David B. Bylund
openaire   +1 more source

Effect of buthionine sulfoximine on gastric ulcer in rats

European Journal of Pharmacology, 1990
G. Bruni, L. Michili, A.I. Fiaschi, G. Giorgi, P. Dal Pra   +4 more
openaire   +1 more source

Buthionine Sulfoximine and Chemoresistance in Cancer Treatments: A Systematic Review With Meta-Analysis of Preclinical Studies

Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 2023
Paulo Michel Pinheiro Ferreira, Andressa Barros Ibiapina, Felipe C Silva   +2 more
exaly  

α-Lipoic Acid Prevents Buthionine Sulfoximine-Induced Cataract Formation in Newborn Rats

Free Radical Biology and Medicine, 1995
E Serbinova, Lester Packer, L Packer
exaly