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Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene

Journal of the American Oil Chemists' Society, 1975
AbstractButylated hydroxyanisole and butylated hydroxytoluene are used extensively as food antioxidants. It is estimated that man consumes ca. 0.1 mg/kg body wt daily of these antioxidants. At levels 500 times this level (50 mg/kg/day), both butylated hydroxyanisole and butylated hydroxytoluene appear to be free of any obviously injurious effects ...
openaire   +4 more sources

BHT – Butylated Hydroxytoluene

International Journal of Toxicology, 2023
The Expert Panel for Cosmetic Ingredient Safety reviewed updated information that has become available since their original assessment from 2002, along with updated information regarding product types, and frequency and concentrations of use, and reaffirmed their original conclusion that BHT is safe as a cosmetic ingredient in the practices of use and
Christina, Burnett   +10 more
openaire   +2 more sources

Toxicity of Butylated Hydroxytoluene

New England Journal of Medicine, 1986
openaire   +3 more sources

Reactivity of butylated hydroxytoluene

Free Radical Biology and Medicine, 1996
Butylated hydroxytoluene (BHT) is a synthetic antioxidant that is widely used as an additive in foodstuffs to prevent spoiling. The physical-chemical properties of BHT and many related phenols have been examined previously although the mechanisms by which it exerts its antioxidant properties are poorly understood.
C R, Lambert, H S, Black, T G, Truscott
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Cytogenetic evaluation of butylated hydroxytoluene

Mutation Research/Genetic Toxicology, 1995
Abstract The genotoxicity of butylated hydroxytoluene (BHT) was evaluated using different cytogenetic short-term tests. Chromosome aberrations and anaphase-telophase alterations were analyzed in Chinese hamster ovary (CHO) cells. The induction of sister chromatid exchanges (SCEs) was evaluated in CHO cells as well as in human peripheral blood ...
C A, Grillo, F N, Dulout
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Pulmonary effects of butylated hydroxytoluene in mice

Food Additives and Contaminants, 1994
By virtue of its antioxidant property butylated hydroxytoluene (BHT) is extensively used to prevent rancidity of food materials on storage. Recently pulmonary effects of BHT ingestion have been reported. Present studies were aimed at exploring the effect of BHT on the lungs of mice. Cellular, biochemical and histopathological changes were studied. Male
M, Waseem, J L, Kaw
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Butylated hydroxytoluene modulates DNA methylation in rats

European Journal of Biochemistry, 1998
The major observation of this investigation is that a single intraperitoneal injection of butylated hydroxytoluene (BHT, 60 mg/kg body mass) results within a few hours in a strong increase in nuclear DNA(cytosine‐5)‐methyl transferase (methyl transferase) activity in the liver, kidneys, heart, spleen, brain and lungs of male rats.
B F, Vanyushin   +4 more
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Butylated hydroxytoluene (BHT): A review

Environmental Research, 1982
Abstract The safety of the food additive butylated hydroxytoluene (BHT) for human consumption is being reevaluated by the U.S. Food and Drug Administration and by the Joint Expert Committee on Food Additives of the Food and Agriculture Organization and the World Health Organization of the United Nations. There are few studies on the effects of BHT to
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DNA cleavage by metabolites of butylated hydroxytoluene

Archives of Toxicology, 1993
The effect of butylated hydroxytoluene (BHT) and its metabolites on DNA cleavage in vitro was studied with supercoiled plasmid DNA, pUC18, by agarose gel electrophoresis. Among several BHT metabolites, 2,6-di-t-butyl-p-benzoquinone (BHT-quinone) caused cleavage of supercoiled DNA (form I) at a concentration as low as 1 x 10(-6) M.
F, Nagai, K, Ushiyama, I, Kano
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