Results 181 to 190 of about 21,456 (229)

Excretion of dietary butylated hydroxytoluene by the rat

Toxicology Letters, 1980
The concentration of phenols in the urine or feces of rats receiving a diet containing 1.00% butylated hydroxytoluene (BHT) for 10 days was determined colorimetrically. The cumulative intake of BHT was approx. 5.0 mmol/rat for 10 days. The total amount of phenols excreted in urine and feces was 3.65 mmol/rat for 10 days, i.e.
O, Takahashi, K, Hiraga
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DNA cleavage by metabolites of butylated hydroxytoluene

Archives of Toxicology, 1993
The effect of butylated hydroxytoluene (BHT) and its metabolites on DNA cleavage in vitro was studied with supercoiled plasmid DNA, pUC18, by agarose gel electrophoresis. Among several BHT metabolites, 2,6-di-t-butyl-p-benzoquinone (BHT-quinone) caused cleavage of supercoiled DNA (form I) at a concentration as low as 1 x 10(-6) M.
F, Nagai, K, Ushiyama, I, Kano
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Potentiation of vitamin A hepatotoxicity by butylated hydroxytoluene

Toxicology and Applied Pharmacology, 1987
The interaction between the natural vitamin A ester retinyl acetate (RA) and the phenolic antioxidant butylated hydroxytoluene (BHT) in the induction of biliary hyperplasia and hepatic fibrosis in female Sprague-Dawley rats was characterized. Using a 3 X 3 matrix design, rats were fed diets supplemented with (per kilogram diet) 0, 125, or 250 mg RA and/
D L, McCormick, T A, Hultin, C J, Detrisac   +2 more
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Comparative pharmacokinetics of butylated hydroxyanisole and butylated hydroxytoluene in rabbits

Journal of Pharmaceutical Sciences, 1980
The widespread use of butylated hydroxyanisole (I) and butylated hydroxytoluene (II) as food antioxidants recently has been criticized by the Food and Drug Administration because of their pharmacological and toxicological effects. Interest also has arisen recently in the use of these compounds as anticancer agents.
R, El-Rashidy, S, Niazi
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Effects of butylated hydroxytoluene on Tetrahymena pyriformis

Food and Cosmetics Toxicology, 1976
The biological effect of butylated hydroxyanisole (BHA) at the molecular level in a eukaryotic system was studied using Tetrahymena pyriformis. BHA at 20 ppm in the medium inhibited cell growth by 50% and the synthesis of DNA, RNA and protein also by 50%. Kinetic experiments indicated that inhibition of the synthesis of all three types of macromolecule
J G, Surak, R L, Bradley, A L, Branen, W E, Ribelin, E, Shrago   +4 more
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Review of the mutagenicity/genotoxicity of butylated hydroxytoluene

Mutation Research/Reviews in Genetic Toxicology, 1992
Butylated hydroxytoluene (BHT) is an effective, widely used, low cost antioxidant. A host of studies examining the potential of BHT to cause point mutations have been published. They include in vitro studies on various bacterial species and strains and on various types of mammalian cell lines as well as in vivo studies on Drosophila melanogaster, silk ...
E M, Bomhard, J N, Bremmer, B A, Herbold
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Butylated hydroxytoluene as a skin lightener.

Archives of dermatology, 1974
The possible skin lightening properties of butylated hydroxytoluene were investigated by patch testing and a normal usage test on black-skinned volunteers. No evidence of depigmentation was observed in this series.
B, Bentley-Phillips, M A, Bayles
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Butylated hydroxytoluene (BHT): A review

Environmental Research, 1982
Abstract The safety of the food additive butylated hydroxytoluene (BHT) for human consumption is being reevaluated by the U.S. Food and Drug Administration and by the Joint Expert Committee on Food Additives of the Food and Agriculture Organization and the World Health Organization of the United Nations. There are few studies on the effects of BHT to
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Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene

Journal of the American Oil Chemists' Society, 1975
AbstractButylated hydroxyanisole and butylated hydroxytoluene are used extensively as food antioxidants. It is estimated that man consumes ca. 0.1 mg/kg body wt daily of these antioxidants. At levels 500 times this level (50 mg/kg/day), both butylated hydroxyanisole and butylated hydroxytoluene appear to be free of any obviously injurious effects ...
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STUDIES ON THE PHOTOPROTECTIVE MECHANISM OF BUTYLATED HYDROXYTOLUENE

Photochemistry and Photobiology, 1984
AbstractIt has been suggested that butylated hydroxytoluene (BHT)‡, a phenolic antioxidant that conveys photoprotective properties to skin, may act by altering epidermal parameters that influence the level of ultraviolet light (UV) reaching critical target sites. The potential diminution of effective UV dose could account for the observed inhibition of
H S, Black, W, Lenger, J, Gerguis, V, McCann   +3 more
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