Results 191 to 200 of about 21,456 (229)

The effect of butylated hydroxyanisole and butylated hydroxytoluene on behavioral development of mice

Developmental Psychobiology, 1974
AbstractThe chronic ingestion of .5% butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) by pregnant mice and their offspring resulted in a variety of behavioral changes. Compared to controls, BHA‐treated offspring showed increased exploration, decreased sleeping, decreased self‐grooming, slower learning, and a decreased orientation reflex.
J D, Stokes, C L, Scudder
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Butylated Hydroxytoluene Toxicity

1992
The phenolic antioxidant butylated hydroxytoluene (BHT) causes toxic effects in experimental animals including hemorrhage, lung, liver and kidney injury, and tumor promotion. ADI values of 0–0.125 (WHO) and 0–0.05 (EEC) mg/kg body weight have been derived from toxicological animal studies.
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Cytotoxicity of butylated hydroxyanisole and butylated hydroxytoluene in isolated rat hepatocytes

Biochemical Pharmacology, 1988
The effects of the antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on isolated rat hepatocytes were investigated. Both antioxidants were observed to be cytotoxic in a concentration-dependent manner at concentrations ranging from 100 to 750 microM. At equimolar concentrations BHT was more cytotoxic than BHA. Their toxicity
D, Thompson, P, Moldéus
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Inhibition of the mono-oxygenase system by butylated hydroxyanisole and butylated hydroxytoluene

Life Sciences, 1974
Abstract The commonly used food-additive antioxidants, butylated hydroxyanisole and butylated hydroxytoluene, are inhibitors of the hepatic microsomal mono-oxygenase system, as assayed by benzpyrene hydroxylase activity and demethylase activities. Generally, butylated hydroxyanisole is a more potent inhibitor than butylated hydroxytoluene.
C S, Yang, F S, Strickhart, G K, Woo
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Cytotoxicity of butylated hydroxytoluene and butylated hydroxyanisole in cultured heart cells

Toxicology, 1978
Butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) at concentrations of 100 ppm (0.45 and 0.55 mM, respectively) produced a marked leakage of lactic dehydrogenase (LDH) from cultured myocardial and endotheloid cells into the culture medium. At this concentration both BHT and BHA markedly depressed the beating rate of cultured heart cells
S W, Leslie, S C, Gad, D, Acosta
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Excretion of butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) by man

Food and Cosmetics Toxicology, 1967
Abstract After a single oral dose of [ 14 C]butylated hydroxytoluene (BHT) to man, about 75% of the administered radioactivity is excreted in the urine; with [ 14 C]butylated hydroxyanisole (BHA) the proportion is rather higher, in the region of 80–90%. The kinetics of excretion is similar for both BHA and BHT.
J W, Daniel, J C, Gage, D I, Jones, M A, Stevens   +3 more
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Butylated hydroxytoluene modulates DNA methylation in rats

European Journal of Biochemistry, 1998
The major observation of this investigation is that a single intraperitoneal injection of butylated hydroxytoluene (BHT, 60 mg/kg body mass) results within a few hours in a strong increase in nuclear DNA(cytosine‐5)‐methyl transferase (methyl transferase) activity in the liver, kidneys, heart, spleen, brain and lungs of male rats.
B F, Vanyushin, N G, Lopatina, C K, Wise, F R, Fullerton, L A, Poirier   +4 more
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Species differences in the haemorrhagic response to butylated hydroxytoluene

Food and Cosmetics Toxicology, 1980
Butylated hydroxytoluene (BHT) was administered in the diet to Sprague-Dawley, Wistar, Donryu and Fischer rats, ICR, ddY, DBA/c, C3H/He, BALB/cAn and C57BL/6 mice, New Zealand White-Sat rabbits, beagle dogs and Japanese quail, and by ip injection to Hartley guinea-pigs and Syrian golden hamsters.
O, Takahashi, S, Hayashida, K, Hiraga
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Effects of butylated hydroxytoluene alone or with diethylnitrosamine in mice

Food and Cosmetics Toxicology, 1974
Abstract Mice (18 months old) given butylated hydroxytoluene (BHT) at a dietary level of 0·75% for 16 months had 63·6% of lung tumours compared with 24·0% in controls. Mice given dietary BHT as well as diethylnitrosamine (DENA) in the drinking-water (average total intake 330 mg DENA/kg) had more lung tumours per mouse (4·0) than did the controls or ...
N K, Clapp, R L, Tyndall, R B, Cumming, J A, Otten   +3 more
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Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT)

Pharmacology & Therapeutics, 1989
Revue de synthese sur le butylhydroxytoluene: metabolisme, toxicite pulmonaire, utilisation en tant qu'outil ...
H, Witschi, A M, Malkinson, J A, Thompson   +2 more
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