Results 1 to 10 of about 120,336 (337)

Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease

Cells, 2021
The microbial metabolite butyrate serves as a link between the intestinal microbiome and epithelium. The monocarboxylate transporters MCT1 and SMCT1 are the predominant means of butyrate transport from the intestinal lumen to epithelial cytoplasm, where ...
Pooja S. Salvi, Robert A. Cowles
doaj   +2 more sources

Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

Frontiers in Microbiology, 2023
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological importance than the other major SCFAs (acetate and propionate).
Vineet Singh, GyuDae Lee, HyunWoo Son, Hong Koh, Eun Soo Kim, Tatsuya Unno, Jae-Ho Shin, Jae-Ho Shin   +7 more
doaj   +2 more sources

The impact of butyrate on glycemic control in animals and humans: a comprehensive semi-systemic review [PDF]

Frontiers in Nutrition
The gut microbiome has been identified as a significant factor in host metabolism, playing a key role in the etiology of obesity, type 2 diabetes and cardiometabolic risk. Butyrate, produced by the gut microbiome from indigestible carbohydrates, has been
Nouhaila Hamari, Ellen E. Blaak, Emanuel E. Canfora   +2 more
doaj   +2 more sources

Time‐Dependent Changes in Effects of Butyrate on Human Gingival Fibroblasts [PDF]

Clinical and Experimental Dental Research
Objectives Butyrate is one of major metabolites of periodontitis‐associated bacteria and often detected in periodontal pockets. Butyrate has been considered to affect human gingival fibroblasts (HGFs); however, there was no information on its long‐term ...
Haruki Otani, Jumpei Washio, Aoi Kunitomi, Satoko Sato, Yuki Abiko, Shiori Sasaki, Kazumasa Ohashi, Satoru Yamada, Nobuhiro Takahashi   +8 more
doaj   +2 more sources

Gut microbial metabolite butyrate suppresses hepatocellular carcinoma growth via CXCL11-dependent enhancement of natural killer cell infiltration [PDF]

Gut Microbes
Gut microbiota-derived butyrate plays a vital role in attenuating hepatocellular carcinoma (HCC) in murine models. However, the precise molecular mechanisms by which butyrate exerts its effects are largely undefined. Plasma short-chain fatty acids (SCFAs)
Menghan Zhang, Xuefeng Huang, Yanlong Zhang, Minghang Yu, Xiaoxue Yuan, Yifan Xu, Lei Ma, Xi Wang, Huichun Xing   +8 more
doaj   +2 more sources

Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review

Nutrients, 2023
Background and objective: Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic inflammatory disorder characterized by aberrant immune responses and compromised barrier function in the gastrointestinal tract ...
Neeraja Recharla, Ramasatyaveni Geesala, Xuan-Zheng Shi   +2 more
semanticscholar   +1 more source

Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells

Gut, 2023
Objective Roseburia intestinalis is a probiotic species that can suppress intestinal inflammation by producing metabolites. We aimed to study the role of R. intestinalis in colorectal tumourigenesis and immunotherapy. Design R. intestinalis abundance was
X. Kang, Changan Liu, Yanqiang Ding, Yunbi Ni, Fenfen Ji, H. C. Lau, Lanping Jiang, J. J. Sung, S. Wong, Jun Yu   +9 more
semanticscholar   +1 more source

Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell

Gut microbes, 2023
Recent studies have demonstrated that the antitumor immunity of immune cells can be modulated by gut microbiota and their metabolites. However, the underlying mechanisms remain unclear.
Xinhai Zhu, Ke Li, Guichao Liu, Ruan Wu, Yan Zhang, Si-Yun Wang, Meng Xu, Ligong Lu, Peng Li   +8 more
semanticscholar   +1 more source

Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease

Gut microbes, 2021
Host-microbial cross-talk plays a crucial role in maintenance of gut homeostasis. However, how microbiota-derived metabolites, e.g., butyrate, regulate functions of neutrophils in the pathogenesis of inflammatory bowel disease (IBD) remains elusive.
Gengfeng Li, Jian Lin, Cui Zhang, Han Gao, Huiying Lu, Xiang Gao, Ruixin Zhu, Zhitao Li, Mingsong Li, Zhanju Liu   +9 more
semanticscholar   +1 more source

Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids

Journal of Translational Medicine, 2023
Background Diabetic retinopathy (DR) development is associated with disturbances in the gut microbiota and related metabolites. Butyric acid is one of the short-chain fatty acids (SCFAs), which has been found to possess a potential antidiabetic effect ...
Yinhua Huang, Zhijie Wang, Bo Ye, J. Ma, Shangli Ji, Wang Sheng, Suna Ye, Yiwen Ou, Yanfang Peng, Xu Yang, Jiansu Chen, Shibo Tang   +11 more
semanticscholar   +1 more source