Results 11 to 20 of about 183,656 (338)

Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

Frontiers in Microbiology, 2023
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological importance than the other major SCFAs (acetate and propionate).
Vineet Singh, GyuDae Lee, HyunWoo Son, Hong Koh, Eun Soo Kim, Tatsuya Unno, Jae-Ho Shin, Jae-Ho Shin   +7 more
doaj   +1 more source

Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice

Gut Microbes, 2021
Emerging research evidence has established the critical role of the gut-liver axis in the development of alcohol-associated liver disease (ALD). The present study employed 16S rRNA gene and whole genome shotgun (WGS) metagenomic analysis in combination ...
Richa Singhal, Hridgandh Donde, Smita Ghare, Kendall Stocke, Jingwein Zhang, Manicka Vadhanam, Sreelatha Reddy, Leila Gobejishvili, Paula Chilton, Swati Joshi-Barve, Wenke Feng, Craig McClain, Kristi Hoffman, Joseph Petrosino, Marius Vital, Shirish Barve   +15 more
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Higher total faecal short-chain fatty acid concentrations correlate with increasing proportions of butyrate and decreasing proportions of branched-chain fatty acids across multiple human studies

Gut Microbiome, 2022
Metabolites produced by microbial fermentation in the human intestine, especially short-chain fatty acids (SCFAs), are known to play important roles in colonic and systemic health.
Maria LaBouyer, Grietje Holtrop, Graham Horgan, Silvia W. Gratz, Alvaro Belenguer, Nicola Smith, Alan W. Walker, Sylvia H. Duncan, Alexandra M. Johnstone, Petra Louis, Harry J. Flint, Karen P. Scott   +11 more
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Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells

Redox Biology, 2017
Butyrate is one of the short chain fatty acids, produced by the gut microbiota during anaerobic fermentation of dietary fibres. It has been shown that it can inhibit tumor progression via suppressing histone deacetylase and can induce apoptosis in cancer
Kishor Pant, Ajay K. Yadav, Parul Gupta, Rakibul Islam, Anoop Saraya, Senthil K. Venugopal   +5 more
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Alternative splicing regulated by butyrate in bovine epithelial cells. [PDF]

PLoS ONE, 2012
As a signaling molecule and an inhibitor of histone deacetylases (HDACs), butyrate exerts its impact on a broad range of biological processes, such as apoptosis and cell proliferation, in addition to its critical role in energy metabolism in ruminants ...
Sitao Wu, Congjun Li, Wen Huang, Weizhong Li, Robert W Li   +4 more
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Experiments and simulations on short chain fatty acid production in a colonic bacterial community [PDF]

, 2018
Understanding how production of specific metabolites by gut microbes is modulated by interactions with surrounding species and by environmental nutrient availability is an important open challenge in microbiome research.
Bobrow, Johanna, Dukovski, Ilija, Kong, David, Ostrinskaya, Alla, Segre, Daniel, Thorsen, Todd, Yu, Bea   +6 more
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Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]

, 2016
Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo, Arluzea, Jon, Aréchaga, Juan, De Wever, Olivier, Díaz-Núñez, María, Díez-Torre, Alejandro, Silió, Margarita   +6 more
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Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats

Journal of Pharmacological Sciences, 2021
Short chain fatty acids readily crosses the gut-blood and blood–brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous system ...
Toshikatsu Okumura, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Shima Kumei, Masumi Ohhira   +5 more
doaj   +1 more source

Plasma metabolites reflect seasonally changing metabolic processes in a long-distance migrant shorebird (Calidris canutus) [PDF]

, 2002
Migrant birds have tightly scheduled annual cycles consisting of several distinct life cycle (sub-)stages such as reproduction, migration, moult and overwintering, each of which have specific metabolic requirements (e.g., fattening during migration ...
Jenni, Lukas,, Jenni-Eiermann, Susanne,, Piersma, Theunis,   +2 more
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Oral Supplementation With Butyrate Improves Myocardial Ischemia/Reperfusion Injury via a Gut-Brain Neural Circuit

Frontiers in Cardiovascular Medicine, 2021
Objective: Butyrate, a short-chain fatty acid (SCFA) produced by the intestinal microbiota, plays a protective role in cardiovascular diseases (CVDs), but the mechanisms involved in this process remain unelucidated.
Zhiyao Yu, Zhiyao Yu, Zhiyao Yu, Zhiyao Yu, Jiapeng Han, Jiapeng Han, Jiapeng Han, Jiapeng Han, Huaqiang Chen, Huaqiang Chen, Huaqiang Chen, Huaqiang Chen, Yueyi Wang, Yueyi Wang, Yueyi Wang, Yueyi Wang, Liping Zhou, Liping Zhou, Liping Zhou, Liping Zhou, Meng Wang, Meng Wang, Meng Wang, Meng Wang, Rong Zhang, Rong Zhang, Rong Zhang, Rong Zhang, Xiaoxing Jin, Xiaoxing Jin, Xiaoxing Jin, Xiaoxing Jin, Guocheng Zhang, Guocheng Zhang, Guocheng Zhang, Guocheng Zhang, Changyi Wang, Changyi Wang, Changyi Wang, Changyi Wang, Tianyou Xu, Tianyou Xu, Tianyou Xu, Tianyou Xu, Mengjie Xie, Mengjie Xie, Mengjie Xie, Mengjie Xie, Xiaofei Wang, Xiaofei Wang, Xiaofei Wang, Xiaofei Wang, Xiaoya Zhou, Xiaoya Zhou, Xiaoya Zhou, Xiaoya Zhou, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +59 more
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