Results 31 to 40 of about 183,656 (338)

A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]

, 2017
The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Marsango, Sara, Millan, Mark J., Milligan, Graeme, Pediani, John D., Ward, Richard J.   +6 more
core   +2 more sources

Butyrate Supplementation at High Concentrations Alters Enteric Bacterial Communities and Reduces Intestinal Inflammation in Mice Infected with Citrobacter rodentium

mSphere, 2017
Butyrate is a short-chain fatty acid by-product of the microbial fermentation of dietary fermentable materials in the large intestine; it is the main energy source for enterocyte regeneration, modulates the enteric microbial community, and contributes to
Janelle A. Jiminez, Trina C. Uwiera, D. Wade Abbott, Richard R. E. Uwiera, G. Douglas Inglis   +4 more
doaj   +1 more source

Butyrate-induced transcriptional changes in human colonic mucosa. [PDF]

PLoS ONE, 2009
Fermentation of dietary fiber in the colon results in the production of short chain fatty acids (mainly propionate, butyrate and acetate). Butyrate modulates a wide range of processes, but its mechanism of action is mostly unknown.
Steven A L W Vanhoutvin, Freddy J Troost, Henrike M Hamer, Patrick J Lindsey, Ger H Koek, Daisy M A E Jonkers, Andrea Kodde, Koen Venema, Robert J M Brummer   +8 more
doaj   +1 more source

An efficient system for intestinal on-site butyrate production using novel microbiome-derived esterases

Journal of Biological Engineering, 2021
Short-chain fatty acids, especially butyrate, play beneficial roles in sustaining gastrointestinal health. However, due to limitations associated with direct consumption of butyrate, there has been interest in using prodrugs of butyrate. Tributyrin (TB),
Dah Hyun Jung, Ji Hyun Yong, Wontae Hwang, Mi Young Yoon, Sang Sun Yoon   +4 more
doaj   +1 more source

Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease [PDF]

, 2015
Copyright © 2015, The American Society for Biochemistry and Molecular Biology. Acknowledgements-We thank Drs Timo Rager and Rolf Hilfiker (Solvias, Switzerland) for polymorph analyses.Peer reviewedPublisher ...
Clunas, Scott, Harrington, Charles R, Harrington, Kathleen A, Horsley, David, Ishaq, Ahtsham, Kemp, Steven J, Larch, Christopher P, Marshall, Colin, Nicoll, Sarah L, Rickard, Janet E, Simpson, Michael, Sinclair, James P, Storey, John M D, Storey, Lynda J, Wischik, Claude M   +14 more
core   +1 more source

16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics. [PDF]

, 2019
The prebiotic potential of nervine herbal medicines has been scarcely studied. We therefore used anaerobic human fecal cultivation to investigate whether medicinal herbs commonly used as treatment in neurological health and disease in Ayurveda and other ...
Albayrak, Levent, Chopra, Deepak, Fofanov, Yuriy, Iablokov, Stanislav N, Khanipov, Kamil, Mills, Paul J, Peterson, Christine Tara, Peterson, Scott N, Rodionov, Dmitry A, Sharma, Vandana, Uchitel, Sasha   +10 more
core   +5 more sources

Butyrate reduces cellular magnesium absorption independently of metabolic regulation in Caco-2 human colon cells

Scientific Reports, 2022
Digestion of dietary fibers by gut bacteria has been shown to stimulate intestinal mineral absorption [e.g., calcium (Ca2+) and magnesium (Mg2+)]. Although it has been suggested that local pH and short-chain fatty acid (SCFA) concentrations determine ...
Lisanne M. M. Gommers, Pieter A. Leermakers, Jenny van der Wijst, Sara R. Roig, Anastasia Adella, Melissa A. E. van de Wal, René J. M. Bindels, Jeroen H. F. de Baaij, Joost G. J. Hoenderop   +8 more
doaj   +1 more source

Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. [PDF]

, 2020
Death due to sepsis remains a persistent threat to critically ill patients confined to the intensive care unit and is characterized by colonization with multi-drug-resistant healthcare-associated pathogens.
Alverdy, John C, Antonopoulos, Dionysios A, Barreiro, Luis B, Bouziat, Romain, Christley, Scott, DeFazio, Jennifer R, Ernest, Jordan D, Fleming, Irma D, Gilbert, Jack A, Harris, Katharine G, Hyoju, Sanjiv K, Jabri, Bana, Keskey, Robert, Khodarev, Nikolai N, Kim, Sangman M, Krezalek, Monika A, Malik, Ankit, Ranoa, Diana R, Sangani, Kishan, Sangwan, Naseer, Shakhsheer, Baddr A, Weichselbaum, Ralph R, Wiegerinck, Mara, Zaborin, Alexander, Zaborina, Olga   +24 more
core  

Iron Modulates Butyrate Production by a Child Gut Microbiota In Vitro

mBio, 2015
The aim of this study was to investigate the effect of iron (Fe) availability on butyrate production in the complex bacterial ecosystem of the human gut.
Alexandra Dostal, Christophe Lacroix, Lea Bircher, Van Thanh Pham, Rainer Follador, Michael Bruce Zimmermann, Christophe Chassard   +6 more
doaj   +1 more source

Dietary Protected Butyrate Supplementation of Broilers Modulates Intestinal Tight Junction Proteins and Stimulates Endogenous Production of Short Chain Fatty Acids in the Caecum

Animals, 2022
Short chain fatty acid (SCFA) butyrate has various beneficial effects on the gut microbiota as well as on the overall health status and metabolism of the host organism.
Gábor Mátis, Máté Mackei, Bart Boomsma, Hedvig Fébel, Katarzyna Nadolna, Łukasz Szymański, Joan E. Edwards, Zsuzsanna Neogrády, Krzysztof Kozłowski   +8 more
doaj   +1 more source