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Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations [PDF]
EpigeneticsWhile genetic studies have provided insights into essential hypertension (EH, defined by high blood pressure ≥140/90 mmHg), investigation through epigenetics may address gaps in understanding its heritability.
Camila Cristina Avila Martins +7 more
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Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introdução: Utilizar células-tronco para avaliações toxicológicas parece ser uma estratégia promissora para permitir uma maior predição de efeitos em humanos. Entretanto, no Brasil, não existe legislação específica que regulamente o uso de células-tronco
Cintia Delai da Silva Horinouchi +6 more
doaj +7 more sources
Alternative Methods as Tools for Obesity Research: In Vitro and In Silico Approaches
Life, 2022 The study of adipogenesis is essential for understanding and treating obesity, a multifactorial problem related to body fat accumulation that leads to several life-threatening diseases, becoming one of the most critical public health problems worldwide ...
Juliana Helena Pamplona +11 more
doaj +1 more source
Low expression of ZHX1 and ZHX2 impacts on the prognosis of chronic lymphocytic leukemia
Biomarker Research, 2021 Experimental evidence points to the role of Zinc fingers and homeoboxes protein 1 and 2 (ZHX1 and ZHX2) in the development and progression of several types of cancer, including hematological malignancies.
Natália Ioseph Gladistone Maciel +5 more
doaj +1 more source
Hematology, Transfusion and Cell Therapy, 2021 Objetivos: LSD1 e LSD2 codificam enzimas desmetilases que primariamente regulam a transcrição gênica por desmetilar a histona 3, mas que também podem diretamente desmetilar proteínas específicas, que possuem importante impacto oncogênico, como p53, E2F ...
DF Costa +7 more
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Viruses, 2021 The Zika virus (ZIKV) has shown a promising oncolytic effect against embryonal CNS tumors. However, studies on the effect of different administration routes and the ideal viral load in preclinical models are highly relevant aiming for treatment safety ...
Raiane Oliveira Ferreira +6 more
doaj +1 more source
Stem Cell Research & Therapy, 2023 Background Detrusor underactivity is a disease that can cause chronic urinary tract infection, urinary tract infection, urinary retention and kidney failure and has no effective treatment in traditional medicine.
Henrique Rodrigues Scherer Coelho +4 more
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Frontiers in Cellular Neuroscience, 2022 Biallelic pathogenic variants in TBCK cause encephaloneuropathy, infantile hypotonia with psychomotor retardation, and characteristic facies 3 (IHPRF3). The molecular mechanisms underlying its neuronal phenotype are largely unexplored.
Danielle de Paula Moreira +20 more
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Pharmaceutics, 2022 Gomphrena celosioides is a native Brazilian plant found in the State of Mato Grosso do Sul. It is used in folk medicine to treat kidney diseases, skin diseases, infections, rheumatism, gastrointestinal diseases, and respiratory diseases.
Fabricia Rodrigues Salustriano +15 more
doaj +1 more source
Journal of Neurodevelopmental Disorders, 2019 Background Phelan-McDermid syndrome (PMS) is a rare genetic disorder characterized by global developmental delay, intellectual disability (ID), autism spectrum disorder (ASD), and mild dysmorphisms associated with several comorbidities caused by SHANK3 ...
Claudia Ismania Samogy-Costa +12 more
doaj +1 more source