Results 1 to 10 of about 18,339 (165)
The most common structural variant expected at the GBA1 locus may be detected by a simple amplification method: Implications for screening Parkinson’s disease variants [PDF]
Clinical Parkinsonism & Related DisordersIntroduction: Recombinant alleles are responsible for a large part of Gaucher disease (GD) causing alterations. This is because GBA1, the gene involved in GD, has a 96 % homologous pseudogene, GBAP1, at a 1.6kb distance.
Roberto Rozenberg +4 more
doaj +2 more sources
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introdução: Utilizar células-tronco para avaliações toxicológicas parece ser uma estratégia promissora para permitir uma maior predição de efeitos em humanos. Entretanto, no Brasil, não existe legislação específica que regulamente o uso de células-tronco
Cintia Delai da Silva Horinouchi +6 more
doaj +7 more sources
Alternative Methods as Tools for Obesity Research: In Vitro and In Silico Approaches
Life, 2022 The study of adipogenesis is essential for understanding and treating obesity, a multifactorial problem related to body fat accumulation that leads to several life-threatening diseases, becoming one of the most critical public health problems worldwide ...
Juliana Helena Pamplona +11 more
doaj +1 more source
Low expression of ZHX1 and ZHX2 impacts on the prognosis of chronic lymphocytic leukemia
Biomarker Research, 2021 Experimental evidence points to the role of Zinc fingers and homeoboxes protein 1 and 2 (ZHX1 and ZHX2) in the development and progression of several types of cancer, including hematological malignancies.
Natália Ioseph Gladistone Maciel +5 more
doaj +1 more source
Hematology, Transfusion and Cell Therapy, 2021 Objetivos: LSD1 e LSD2 codificam enzimas desmetilases que primariamente regulam a transcrição gênica por desmetilar a histona 3, mas que também podem diretamente desmetilar proteínas específicas, que possuem importante impacto oncogênico, como p53, E2F ...
DF Costa +7 more
doaj +1 more source
Viruses, 2021 The Zika virus (ZIKV) has shown a promising oncolytic effect against embryonal CNS tumors. However, studies on the effect of different administration routes and the ideal viral load in preclinical models are highly relevant aiming for treatment safety ...
Raiane Oliveira Ferreira +6 more
doaj +1 more source
Stem Cell Research & Therapy, 2023 Background Detrusor underactivity is a disease that can cause chronic urinary tract infection, urinary tract infection, urinary retention and kidney failure and has no effective treatment in traditional medicine.
Henrique Rodrigues Scherer Coelho +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Biallelic pathogenic variants in TBCK cause encephaloneuropathy, infantile hypotonia with psychomotor retardation, and characteristic facies 3 (IHPRF3). The molecular mechanisms underlying its neuronal phenotype are largely unexplored.
Danielle de Paula Moreira +20 more
doaj +1 more source
Human adipose-derived stem cells: current challenges and clinical perspectives [PDF]
, 2010 Adult or somatic stem cells hold great promise for tissue regeneration. Currently, one major scientific interest is focused on the basic biology and clinical application of mesenchymal stem cells.
Okamoto, Oswaldo Keith, Yarak, Samira
core +4 more sources
Quality of life following allogeneic, hematopoietic stem cell transplantation: a longitudinal study [PDF]
, 2011 Este estudo teve como objetivo avaliar a qualidade de vida de pacientes submetidos ao transplante de células-tronco hematopoéticas alogênico, comparando as fases pré-transplante de células-tronco hematopoéticas, o momento do isolamento protetor na ...
MASTROPIETRO, Ana Paula +4 more
core +1 more source