Results 91 to 100 of about 463,675 (222)
Frontiers in Microbiology, 2021 A number of bacterial species control the function of the flagellar motor in response to the levels of the secondary messenger c-di-GMP, which is often mediated by c-di-GMP-binding proteins that act as molecular brakes or clutches to slow the motor ...
Anna Pecina +7 more
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mBio, 2021 Key findings in model organisms led to the concept of “local” signaling, challenging the dogma of a gradually increasing global intracellular c-di-GMP concentration driving the motile-sessile transition in bacteria.
Eike H. Junkermeier, R. Hengge
semanticscholar +1 more source
Optogenetic Module for Dichromatic Control of c-di-GMP Signaling [PDF]
Journal of Bacteriology, 2017 ABSTRACT Many aspects of bacterial physiology and behavior, including motility, surface attachment, and the cell cycle, are controlled by cyclic di-GMP (c-di-GMP)-dependent signaling pathways on the scale of seconds to minutes.
Anastasia Fomicheva +3 more
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BMC Microbiology, 2022 Background Staphylococcus aureus is a leading cause for morbidity and mortality associated with skin and burn wound infections. Therapeutic options for methicillin-resistant S. aureus (MRSA) have dwindled and therefore alternative treatments are urgently
Shuai Gao +6 more
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mSystems, 2021 c-di-GMP/FleQ promotes the plankton-to-biofilm lifestyle transition at the transcriptional level via FleQ in Pseudomonas species. Identification of new target genes directly regulated by c-di-GMP/FleQ helps to broaden the knowledge of c-di-GMP/FleQ ...
Yujie Xiao +8 more
semanticscholar +1 more source
Structural basis of ligand binding by a c-di-GMP riboswitch [PDF]
Nature Structural & Molecular Biology, 2009 The second messenger signaling molecule bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) regulates many processes in bacteria, including motility, pathogenesis and biofilm formation. c-di-GMP-binding riboswitches are important downstream targets in this signaling pathway. Here we report the crystal structure, at 2.7 A resolution, of a c-di-
Kathryn D. Smith +6 more
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npj Biofilms and Microbiomes, 2022 The polysaccharide Bep is essential for in vitro biofilm formation of the opportunistic pathogen Burkholderia cenocepacia. We found that the Burkholderia diffusible signaling factor (BDSF) quorum sensing receptor RpfR is a negative regulator of the bep ...
Elisabeth Steiner +8 more
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C‐di‐GMP: the dawning of a novel bacterial signalling system [PDF]
Molecular Microbiology, 2005 SummaryBis‐(3′‐5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP) has come to the limelight as a result of the recent advances in microbial genomics and increased interest in multicellular microbial behaviour. Known for more than 15 years as an activator of cellulose synthase in Gluconacetobacter xylinus, c‐di‐GMP is emerging as a novel global ...
Ute Römling +2 more
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Extraction and Quantification of Cyclic Di-GMP from Pseudomonas aeruginosa
Bio-Protocol, 2013 Cyclic di-GMP (c-di-GMP) has emerged as an important intracellular signaling molecule, controlling the transitions between planktonic (free-living) and sessile lifestyles, biofilm formation, and virulence in a wide variety of microorganisms.
Ankita Roy, Olga Petrova, Karin Sauer
doaj +1 more source
You’ve come a long way: c-di-GMP signaling [PDF]
Current Opinion in Microbiology, 2012 Cyclic dimeric guanosine monophosphate (c-di-GMP) is a common, bacterial second messenger that regulates diverse cellular processes in bacteria. Opposing activities of diguanylate cyclases (DGCs) and phosphodiesterases (PDEs) control c-di-GMP homeostasis in the cell.
Holger Sondermann +2 more
openaire +3 more sources