Results 181 to 190 of about 459,122 (273)

The efficacy of PDE5 inhibitors in diabetic patients

Andrology, Volume 11, Issue 2, Page 245-256, February 2023., 2023
Abstract Background Phosphodiesterase 5 inhibitors (PDE5i), since their introduction in the late 1990s, have proven their efficacy in treating several conditions, predominantly pulmonary hypertension and erectile dysfunction where they remain the first‐line therapeutic option.
Agnieszka Swiecicka
wiley   +1 more source

A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in Escherichia coli. [PDF]

Front Chem
Li H, Quan S, He W.
europepmc   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates. [PDF]

NPJ Biofilms Microbiomes
Cai YM, Hong F, De Craemer A, Malone JG, Crabbé A, Coenye T.   +5 more
europepmc   +1 more source

MshEN: possible for c-di-GMP binding [PDF]

Nature Reviews Microbiology, 2016
openaire   +2 more sources

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Exploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

The c-di-GMP effector FleQ controls alginate production by repressing transcription of <i>algD</i> in <i>Azotobacter vinelandii</i>. [PDF]

Microbiology (Reading)
Barrios-Rafael VV, Ahumada-Manuel CL, Orgaz-Ramírez S, Nava-Galeana J, Guzmán J, Moreno S, Bustamante VH, Núñez C.   +7 more
europepmc   +1 more source

Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules

, 2016
Clement Opoku‐Temeng, Jie Zhou, Yue Zheng, Jianmei Su, Herman O. Sintim   +4 more
openalex   +2 more sources

Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core‐Shell Manganese Phosphate/siPD‐L1 Modulator

Exploration, EarlyView.
To enhance the comprehensive treatment effect of triple‐negative breast cancer, a pH‐responsive core‐shell manganese phosphate nano‐regulator was prepared to reprogram the tumor microenvironment bi‐directionally. (1) “Brakes off”: Using siPD‐L1 to inhibit PD‐L1 expression to restore CD8+ T cell function.
Fei Xia, Yuqian Lu, Zipeng Gong, Qingchao Tu, Shuntao Liang, Chen Wang, HaiLu Yao, LinYing Zhong, Yuanfeng Fu, Pengbo Guo, Yichong Hou, Xinyu Zhou, Li Zou, Licheng Gan, Weiqi Chen, Jiawei Yan, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Chen Pan, Xiaomei Tao, Jigang Wang, Qingfeng Du, Chong Qiu   +24 more
wiley   +1 more source

Insertion of a Divergent GAF-like Domain Defines a Novel Family of YcgR Homologues That Bind c-di-GMP in Leptospirales. [PDF]

ACS Omega
Visnardi AB, Ribeiro RA, de Souza AS, Churasacari Vinces TG, Llontop EE, de Almeida Ferrari AS, França Henrique PA, Valdivieso D, Sánchez-Limache DE, Silva GR, Soares EP, Santos TWC, Farah CS, Sassonia RC, Salinas RK, Guzzo CR, de Souza RF.   +16 more
europepmc   +1 more source