c-di-GMP Turn-Over in Clostridium difficile Is Controlled by a Plethora of Diguanylate Cyclases and Phosphodiesterases [PDF]
, 2011 Éric Bordeleau +3 more
openalex +1 more source
A messenger molecule governs interdependency in an evolved Pseudomonas aeruginosa biofilm community [PDF]
, 2011 Biofilm populations are known to harbor great diversity, but the importance of this diversity is not fully understood. A likely contributor to this variation is the second messenger molecule cyclic-di-GMP: low levels associate with a planktonic lifestyle
Johnson, Thomas MacElliott
core +1 more source
A Two‐Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto‐Aerotaxis
Advanced Science, EarlyView.Magnetotactic bacteria align with Earth's magnetic field, helping them migrate toward low‐oxygen environments. This study reveals how Magnetospirillum gryphiswaldense uses a specialized flavin adenine dinucleotide (FAD)‐dependent chemoreceptor, composed of two interacting proteins, for precise navigation in oxygen gradients.
Julian Herz +13 more
wiley +1 more source
Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder
Advanced Science, EarlyView.The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang +13 more
wiley +1 more source
Impact of QseBC system in c-di-GMP-dependent quorum sensing regulatory network in a clinical isolate SSU of Aeromonas hydrophila [PDF]
, 2012 Е. В. Козлова +4 more
openalex +1 more source
Regulation of development by c-di-GMP in Myxococcus xanthus
, 2019 Bei Myxococcus xanthus handelt es sich um ein Modellorganismus zur Untersuchung des soziale Verhaltens und der Zelldifferenzierung von Bakterien. Induziert durch Nährstoffmangel, starten die M.xanthus Zellen ein Entwicklungsprogramm, welches zur Bildung von Sporen gefüllten Fruchtkörpern und peripheren stäbchenförmigen Zellen außerhalb dieser ...
openaire +3 more sources
Advanced Science, EarlyView.This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao +4 more
wiley +1 more source
Capture Compound Mass Spectrometry - A Powerful Tool to Identify Novel c-di-GMP Effector Proteins [PDF]
, 2015 Benoît‐Joseph Laventie +5 more
openalex +2 more sources
Advanced Science, EarlyView.IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu +16 more
wiley +1 more source
Novel Delivery of Cyclic-Diguanylate Monophosphate Utilizing Amyloid Depots
PharmaceuticsBackground: Recently, cyclic diguanylate monophosphate (c-di-GMP) drug delivery has garnered interest due to its potential in cancer immune modulation. In this pilot study, we developed a novel c-di-GMP formulation based on peptide amyloids.
Maytham Ismail +4 more
doaj +1 more source