Results 221 to 230 of about 459,122 (273)

Investigating Dopamine Replacement–Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD. Objective The objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.
Abhimanyu Mahajan, Christopher B. Morrow, Joseph Seemiller, Kelly A. Mills, Gregory M. Pontone   +4 more
wiley   +1 more source

Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor. [PDF]

NPJ Biofilms Microbiomes
Hu XM, Peng L, Wang Y, Ma F, Tao Y, Liang X, Yang JL.   +6 more
europepmc   +1 more source

3D virtual biopsy of in vivo pH and metabolism using PRESS and semi‐LASER MRS of hyperpolarized 13C nuclei

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To develop and evaluate sequences for multi‐voxel magnetic resonance spectroscopy using hyperpolarized molecules. Methods A standard single voxel PRESS sequence was extended to acquire multiple voxels consecutively. Its SNR was compared against a 2D FID‐CSI with both 1H and hyperpolarized 13C nuclei in phantoms and in a healthy mouse ...
Wolfgang Gottwald, Luca Nagel, Martin Grashei, Sebastian Bauer, Nadine Setzer, Florian Gaksch, Sandra Sühnel, Jason G. Skinner, Rickmer Braren, Irina Heid, Geoffrey J. Topping, Franz Schilling   +11 more
wiley   +1 more source

Comparative Genomic and Functional Analysis of c-di-GMP Metabolism and Regulatory Proteins in Bacillus velezensis LQ-3. [PDF]

Microorganisms
Li R, Yang P, Zhang H, Wang C, Zhao F, Liu J, Wang Y, Liang Y, Sun T, Xie X.   +9 more
europepmc   +1 more source

Machine Learning‐Based High‐Throughput Screening, Molecular Modeling and Quantum Chemical Analysis to Investigate Mycobacterium tuberculosis MetRS Inhibitors

ChemistryOpen, EarlyView.
This paper provides a comprehensive approach using the ChEMBL database to construct a machine learning model that screened 10 million compounds from the eMolecules database. Two promising inhibitors targeting Mycobacterium tuberculosis methionyl‐tRNA synthetase were identified.
Rajesh Maharjan, Kalpana Gyawali, Arjun Acharya, Madan Khanal, Kamal Khanal, Mohan Bahadur Kshetri, Madhav Prasad Ghimire, Tika Ram Lamichhane   +7 more
wiley   +1 more source

Local control: a hub-based model for the c-di-GMP network. [PDF]

mSphere
Vasenina A, Fu Y, O'Toole GA, Mucha PJ.
europepmc   +1 more source

Autoinducer-2 enhances the defense of <i>Vibrio furnissii</i> against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system. [PDF]

mBio
Zhang H, Zhao W, Yang W, Zhang H, Qian X, Sun K, Yang Q, Shen X, Zhang L.   +8 more
europepmc   +1 more source

Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal‐Sensing Sensor Histidine Kinase ZraS

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT ZraS is a metal sensor integral to ZraPSR, a two‐component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc‐induced stress on the bacterial envelope.
Nilima Mahapatra, Pranjal Mahanta, Shubhant Pandey, Rudresh Acharya   +3 more
wiley   +1 more source

A Label-Free Approach for Relative Spatial Quantitation of c-di-GMP in Microbial Biofilms. [PDF]

Anal Chem
McCaughey CS, Trebino MA, McAtamney A, Isenberg RY, Mandel MJ, Yildiz FH, Sanchez LM.   +6 more
europepmc   +1 more source

<i>Cronobacter sakazakii</i> lysozyme inhibitor LprI mediated by HmsP and c-di-GMP is essential for biofilm formation and virulence. [PDF]

Appl Environ Microbiol
Ji X, Fan D, Wang J, Zhang B, Hu Y, Lv H, Wu J, Sun Y, Liu J, Zhang Y, Wang S.   +10 more
europepmc   +1 more source