Results 221 to 230 of about 470,032 (357)

Insights into the GTP‐dependent allosteric control of c‐di‐GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa [PDF]

, 2018
Federico Mantoni, Alessandro Paiardini, Paolo Brunotti, Cecilia D’Angelo, L. Cervoni, Alessio Paone, Loredana Cappellacci, Riccardo Petrelli, Massimo Ricciutelli, Livia Leoni, Giordano Rampioni, Alessandro Arcovito, Serena Rinaldo, Francesca Cutruzzolà, Giorgio Giardina   +14 more
openalex   +1 more source

Diguanylate Cyclase GdpX6 with c-di-GMP Binding Activity Involved in the Regulation of Virulence Expression in Xanthomonas oryzae pv. oryzae [PDF]

, 2021
Weiwei Yan, Yiming Wei, Susu Fan, Chao Yu, Fang Tian, Qi Wang, Fenghuan Yang, Huamin Chen   +7 more
openalex   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product

, 2012
S.M. Vorobiev, H. Neely, Bomina Yu, J. Seetharaman, Rong Xiao, Thomas Acton, G.T. Montelione, J.F. Hunt   +7 more
openalex   +2 more sources

Functional Characterization of c-di-GMP Signaling-Related Genes in the Probiotic Lactobacillus acidophilus [PDF]

, 2018
Jiahui He, Wenhao Ruan, Jieli Sun, Fang Wang, Wenjuan Yan   +4 more
openalex   +1 more source

c-di-GMP inhibits early sporulation in Clostridioides difficile [PDF]

, 2021
Adrianne N. Edwards, Caitlin L. Willams, Nivedita Pareek, Shonna M. McBride, Rita Tamayo   +4 more
openalex   +1 more source

Emerging cGAS‐STING Agonist‐Based Nanotherapeutics: Mechanistic Insights and Applications in Cancer Combination Therapy

Advanced Science, EarlyView.
This review summarizes recent advances in cGAS‐STING agonist‐based nanotherapeutics for cancer combination therapy. It explores nanoparticle‐mediated delivery strategies, underlying molecular mechanisms, and combinatorial applications with chemotherapy, radiotherapy, targeted therapy, phototherapy, sonodynamic therapy, and immunotherapy.
Zhaomeng Wang, Yongjun Wang, Zhonggui He, Caigang Liu   +3 more
wiley   +1 more source

A Photon‐Driven Unimolecular Immunostimulant for Self‐Amplified Pyroptosis and cGAS‐STING Pathway by Destroying the Pyroptosis Checkpoint

Angewandte Chemie, EarlyView.
The proposed Bio‐Cy conjugate emerges as an avant‐garde molecular entity, adeptly activating the pyroptosis and cGAS‐STING pathways by disrupting pyroptosis checkpoints to heighten the cytocidal impact of photon‐driven immunotherapy. Abstract Immunotherapy is a groundbreaking approach for clinically treating tumors, but its effectiveness is hindered by
Shuang Zeng, Chen Chen, Zhihan Guo, Chunfang Qin, Yang Wang, Xiaosheng Liu, Xin Li, Hyunsun Jeong, Yifu Hao, Danhong Zhou, Saran Long, Zhenyong Wu, Jingyun Wang, Haidong Li, Xiaojun Peng, Juyoung Yoon   +15 more
wiley   +2 more sources

YjcC, a c-di-GMP Phosphodiesterase Protein, Regulates the Oxidative Stress Response and Virulence of Klebsiella pneumoniae CG43

, 2013
Ching-Jou Huang, Zhe-Chong Wang, Hsi‐Yuan Huang, Hsien‐Da Huang, Hwei‐Ling Peng   +4 more
openalex   +2 more sources

Interplay between the bacterial protein deacetylase CobB and the second messenger c‐di‐ GMP [PDF]

, 2019
Zhaowei Xu, Hainan Zhang, Xingrun Zhang, He‐wei Jiang, Cheng-Xi Liu, Fanlin Wu, Lili Qian, Bingbing Hao, Daniel M. Czajkowsky, Shujuan Guo, Zhijing Xu, Lijun Bi, Shihua Wang, Haitao Li, Minjia Tan, Wei Yan, Lei Feng, Jingli Hou, Sheng‐ce Tao   +18 more
openalex   +1 more source