Results 41 to 50 of about 24,590 (334)

A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa [PDF]

, 2018
Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms in natural environments and in host–pathogen interactions.
Cutruzzolà, F., Giardina, G., Janson, G., Leoni, L., Mantoni, F., Paiardini, A., Paone, A., Rampioni, G., Rinaldo, S.   +8 more
core   +1 more source

Thiophosphate Analogs of c-di-GMP: Impact on Polymorphism [PDF]

Nucleosides, Nucleotides & Nucleic Acids, 2009
Seven phosphorothioate analogs of c-di-GMP (all diastereomers of mono-, di-, and trithiophosphates) were prepared to assess the impact of the thioate substitutions on c-di-GMP polymorphism using 1D (1)H and (31)P NMR, along with 2D NOESY and DOSY, for both the Na(+) and K(+) salts.
Jianwei, Zhao, Elizabeth, Veliath, Seho, Kim, Barbara L, Gaffney, Roger A, Jones   +4 more
openaire   +2 more sources

Visualization of c-di-GMP in multicellular Dictyostelium stages

Frontiers in Cell and Developmental Biology, 2023
The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) is only synthesized and utilized by the cellular slime mold Dictyostelium discoideum among eukaryotes. Dictyostelium cells undergo a transition from a unicellular to a multicellular state, ultimately forming a stalk and spores.
Hayato Ide, Yukihisa Hayashida, Yusuke V. Morimoto, Yusuke V. Morimoto   +3 more
openaire   +3 more sources

A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus [PDF]

, 2016
Generally, the second messenger bis-(3’-5’)-cyclic dimeric GMP (c-di-GMP) regulates the switch between motile and sessile lifestyles in bacteria. Here, we show that c-di-GMP is an essential regulator of multicellular development in the social bacterium ...
A Duerig, A Konovalova, A Lu, AJ Schmidt, B Julien, BK Bharati, BY Chang, BY Matsuyama, BZ Harris, C Baraquet, C Spangler, CD Boyd, D Amikam, D Kaiser, D Skotnicka, D Srivastava, DA Ryjenkov, DA Ryjenkov, Dorota Skotnicka, E Bordeleau, E Trampari, Eleftheria Trampari, Gregory T. Smaldone, H Lancero, I Bulyha, I Letunic, IS Pultz, J Hodgkin, J Hodgkin, J Sambrook, Jacob G. Malone, Jennifer Liang, JJ Wilksch, Josep Casadesús, JP Massie, JT Pratt, JW Hickman, JW Hickman, KG Roelofs, KH Chin, L Hobley, L Jelsbak, L Søgaard-Andersen, LJ Shimkets, Lotte Søgaard-Andersen, M Christen, M Christen, M Fazli, M Merighi, M Overgaard, M Singer, Mitchell Singer, MR Neunuebel, MV Navarro, N Sudarsan, N Tschowri, NB Caberoy, PD Newell, PV Krasteva, PV Krasteva, R Hengge, R Paul, R Paul, R Tamayo, RP Ryan, RP Ryan, RP Ryan, S Abel, S Steiner, SS Wu, SS Wu, SS Wu, SZ Sultan, T Petters, T Schirmer, TA Ramelot, TM Gronewold, Tobias Petters, U Römling, V Jakovljevic, Volkhard Kaever, W Li, X Fang, Y Li, Y Qi, Z Yang, ZH Chen, ZM Yang   +87 more
core   +3 more sources

Multiple activities of c-di-GMP in Pseudomonas aeruginosa [PDF]

Nucleic Acids Symposium Series, 2009
Survival strategies of many bacterial pathogens, including Pseudomonas aeruginosa, are linked to their ability to form surface associated communities called biofilms. The biofilm life style allows these organisms to persist in various tissues, avoid clearance by innate host defences and significantly enhanced their resistance to antibiotics.
Stephen, Lory, Massimo, Merighi, Mamoru, Hyodo   +2 more
openaire   +2 more sources

Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch

Molecules, 2012
C-di-GMP, a cyclic guanine dinucleotide, has been shown to regulate biofilm formation as well as virulence gene expression in a variety of bacteria. Analogues of c-di-GMP have the potential to be used as chemical probes to study c-di-GMP signaling and ...
Herman O. Sintim, Nirmal Pahadi, Jingxin Wang, David A. Sayre, Jie Zhou   +4 more
doaj   +1 more source

Roles of the second messenger cyclic di-GMP in environmental adaptation of Sinorhizobium meliloti [PDF]

, 2017
Bacteria have evolved various systems for the integration of environmental signals to rapidly coordinate cellular pathways and adapt to changes in their environment.
Schäper, Simon
core   +1 more source

Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology, 2017
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cycle in many bacterial species. High intracellular c-di-GMP content enhances biofilm formation via the reduction of motility and production of biofilm ...
Song Lin Chua, Yang Liu, Yingying Li, Hui Jun Ting, Gurjeet S. Kohli, Zhao Cai, Pipob Suwanchaikasem, Kelvin Kau Kit Goh, Sean Pin Ng, Tim Tolker-Nielsen, Liang Yang, Liang Yang, Michael Givskov, Michael Givskov   +13 more
doaj   +1 more source

Fluorescent Detection of the Ubiquitous Bacterial Messenger 3′,5′ Cyclic Diguanylic Acid by Using a Small Aromatic Molecule

Frontiers in Microbiology, 2020
3′,5′ Cyclic diguanylic acid (c-di-GMP) has been shown to play a central role in the regulation of bacterial physiological processes such as biofilm formation and virulence production, and is regarded as a potential target for the development of anti ...
Teng-Fei Xuan, Jun Liu, Zi-Qiang Wang, Wei-Min Chen, Jing Lin   +4 more
doaj   +1 more source

New insights into Legionella pneumophila biofilm regulation by c-di-GMP signaling [PDF]

, 2016
The waterborne pathogen Legionella pneumophila grows as a biofilm, freely or inside amoebae. Cyclic-di-GMP (c-di-GMP), a bacterial second messenger frequently implicated in biofilm formation, is synthesized and degraded by diguanylate cyclases (DGCs) and
Allombert, Julie, Doublet, Patricia, Lajoie Halova, Barbora, Pécastaings, Sophie, Roques, Christine, Vianney, Anne   +5 more
core   +3 more sources