Results 61 to 70 of about 459,122 (273)
Advanced Functional Materials, EarlyView.A visible light‐responsive polyacrylamide‐azobenzene hydrogel enables safe, reversible stiffness control for studying cell mechanobiology without harmful UV exposure. This approach reveals stem cells respond rapidly to mechanical changes, showing altered shape and protein distribution within one hour.
Aafreen Ansari +11 more
wiley +1 more source
Optogenetic Module for Dichromatic Control of c-di-GMP Signaling [PDF]
Journal of Bacteriology, 2017 ABSTRACT Many aspects of bacterial physiology and behavior, including motility, surface attachment, and the cell cycle, are controlled by cyclic di-GMP (c-di-GMP)-dependent signaling pathways on the scale of seconds to minutes.
Anastasia Fomicheva +3 more
openaire +3 more sources
Quantitative input–output dynamics of a c-di-GMP signal transduction cascade in Vibrio cholerae
PLoS Biology, 2022 Bacterial biofilms are multicellular communities that collectively overcome environmental threats and clinical treatments. To regulate the biofilm lifecycle, bacteria commonly transduce sensory information via the second messenger molecule cyclic ...
Andrew A. Bridges +4 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia +7 more
wiley +1 more source
bioRxiv, 2021 The HD-GYP domain, named after two of its conserved sequence motifs, was first described in 1999 as a specialized version of the widespread HD phosphohydrolase domain that had additional highly conserved amino acid residues. Domain associations of HD-GYP
Michael Y. Galperin, S. Chou
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling +4 more
wiley +1 more source
Structural basis of ligand binding by a c-di-GMP riboswitch [PDF]
Nature Structural & Molecular Biology, 2009 The second messenger signaling molecule bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) regulates many processes in bacteria, including motility, pathogenesis and biofilm formation. c-di-GMP-binding riboswitches are important downstream targets in this signaling pathway. Here we report the crystal structure, at 2.7 A resolution, of a c-di-
Kathryn D. Smith +6 more
openaire +3 more sources
Extracellular c-di-GMP Plays a Role in Biofilm Formation and Dispersion of Campylobacter jejuni
Microorganisms, 2022 Cyclic diguanosine monophosphate (c-diGMP) is a ubiquitous second messenger involved in the regulation of many signalling systems in bacteria, including motility and biofilm formation.
Bassam A. Elgamoudi +2 more
semanticscholar +1 more source
Advanced Materials Interfaces, EarlyView.CO2 laser ablation, a fast, inexpensive, and reproducible method, is used to create flexible elastomer molds with millimeter‐long cavities for the fabrication of dissolvable polymer needles. Made from PVP, these milli‐needles achieve ≈560 µm penetration into porcine skin, demonstrating their potential for effective transdermal drug delivery.
Matteo Tollemeto +7 more
wiley +1 more source
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source