Results 61 to 70 of about 17,188 (276)

The RNA Domain Vc1 Regulates Downstream Gene Expression in Response to Cyclic Diguanylate in Vibrio cholerae. [PDF]

PLoS ONE, 2016
In many bacterial species, including the aquatic bacterium and human pathogen Vibrio cholerae, the second messenger cyclic diguanylate (c-di-GMP) modulates processes such as biofilm formation, motility, and virulence factor production.
Ankunda T Kariisa, Kevin Weeks, Rita Tamayo   +2 more
doaj   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

A novel c-di-GMP binding domain in glycosyltransferase BgsA is responsible for the synthesis of a mixed-linkage β-glucan

Scientific Reports, 2017
BgsA is the glycosyltransferase (GT) involved in the synthesis of a linear mixed-linkage β-glucan (MLG), a recently described exopolysaccharide activated by c-di-GMP in Sinorhizobium meliloti and other Rhizobiales.
Daniel Pérez-Mendoza, Daniela Bertinetti, Robin Lorenz, María-Trinidad Gallegos, Friedrich W. Herberg, Juan Sanjuán   +5 more
doaj   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Cyclic-di-GMP stimulates keratinocyte innate immune responses and attenuates methicillin-resistant Staphylococcus aureus colonization in a murine skin wound infection model

BMC Microbiology, 2022
Background Staphylococcus aureus is a leading cause for morbidity and mortality associated with skin and burn wound infections. Therapeutic options for methicillin-resistant S. aureus (MRSA) have dwindled and therefore alternative treatments are urgently
Shuai Gao, Abidullah Khan, Xuhong Chen, Guohui Xiao, Stijn van der Veen, Yin Chen, Xu’ai Lin   +6 more
doaj   +1 more source

The Stand-Alone PilZ-Domain Protein MotL Specifically Regulates the Activity of the Secondary Lateral Flagellar System in Shewanella putrefaciens

Frontiers in Microbiology, 2021
A number of bacterial species control the function of the flagellar motor in response to the levels of the secondary messenger c-di-GMP, which is often mediated by c-di-GMP-binding proteins that act as molecular brakes or clutches to slow the motor ...
Anna Pecina, Meike Schwan, Vitan Blagotinsek, Tim Rick, Patrick Klüber, Tabea Leonhard, Gert Bange, Kai M. Thormann   +7 more
doaj   +1 more source

Optogenetic Module for Dichromatic Control of c-di-GMP Signaling [PDF]

Journal of Bacteriology, 2017
ABSTRACT Many aspects of bacterial physiology and behavior, including motility, surface attachment, and the cell cycle, are controlled by cyclic di-GMP (c-di-GMP)-dependent signaling pathways on the scale of seconds to minutes.
Anastasia Fomicheva, Min-Hyung Ryu, Oleg V. Moskvin, Mark Gomelsky   +3 more
openaire   +3 more sources

Thermoresponsive BrushGel Microcarriers for Efficient Cell Expansion and Enzyme‐Reduced Harvesting

Advanced Healthcare Materials, EarlyView.
Askari et al, report on temperature‐responsive microcarriers to minimize enzyme use and cost in dynamic cultures. Abstract Scaling up cell therapy requires efficient expansion of high‐quality cells. Microcarrier(MC)‐based systems offer high surface‐to‐volume ratios and reduce culture media usage.
Esfandyar Askari, Mahdieh Shokrollahi Barough, Amir Seyfoori, Mahmood Razzaghi, Joel Alexander Ninan, Aidan B. P. Murray, Mahmoud Salkhordeh, Yuan Tan, Shirley H. J. Mei, Mohsen Akbari   +9 more
wiley   +1 more source

Structural basis of ligand binding by a c-di-GMP riboswitch [PDF]

Nature Structural & Molecular Biology, 2009
The second messenger signaling molecule bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) regulates many processes in bacteria, including motility, pathogenesis and biofilm formation. c-di-GMP-binding riboswitches are important downstream targets in this signaling pathway. Here we report the crystal structure, at 2.7 A resolution, of a c-di-
Kathryn D. Smith, Tyler D. Ames, Ronald R. Breaker, Ronald R. Breaker, Sarah V. Lipchock, Scott A. Strobel, Jimin Wang   +6 more
openaire   +3 more sources

A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen‐Based Bioink for Skin Wound Healing Applied by a Handheld Dual‐Head Airbrush

Advanced Healthcare Materials, EarlyView.
A dual‐head airbrush‐based spraying device, combined with a fibrinogen bioink enriched with glycosaminoglycans and collagen, enables the delivery of biomaterials and cells to promote wound healing. This system demonstrates effective skin regeneration in vitro and in vivo, with comparable results to autografts.
Paula Pleguezuelos‐Beltrán, Daniel Nieto‐García, Carlos Chocarro‐Wrona, Juan de Vicente, Patricia Gálvez‐Martín, José Manuel Entrena, Elena López‐Ruiz, Juan Antonio Marchal   +7 more
wiley   +1 more source