Results 61 to 70 of about 24,734 (337)

Gas and light: triggers of c-di-GMP-mediated regulation

FEMS Microbiology Reviews, 2023
AbstractThe widespread bacterial second messenger c-di-GMP is responsible for regulating many important physiological functions such as biofilm formation, motility, cell differentiation, and virulence. The synthesis and degradation of c-di-GMP in bacterial cells depend, respectively, on diguanylate cyclases and c-di-GMP-specific phosphodiesterases ...
Zhaoqing Yu, Wei Zhang, He Yang, Shan-Ho Chou, Michael Y Galperin, Jin He   +5 more
openaire   +2 more sources

CRP-Like Transcriptional Regulator MrpC Curbs c-di-GMP and 3′,3′-cGAMP Nucleotide Levels during Development in Myxococcus xanthus

mBio, 2022
Myxococcus xanthus has a nutrient-regulated biphasic life cycle forming predatory swarms in the presence of nutrients and spore-filled fruiting bodies in the absence of nutrients.
Sofya Kuzmich, Patrick Blumenkamp, Doreen Meier, Dobromir Szadkowski, Alexander Goesmann, Anke Becker, Lotte Søgaard-Andersen   +6 more
doaj   +1 more source

Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre [PDF]

, 2014
Bis-(3′,5′) cyclic di-guanylate (c-di-GMP) is a key bacterial second messenger that is implicated in the regulation of many crucial processes that include biofilm formation, motility and virulence.
An, Shi-Qi, Bellini, Dom, Bumann, Mario, Caly, Delphine L., Dow, J. Maxwell, McCarthy, Yvonne, Ryan, Robert P., Walsh, Martin A.   +7 more
core   +3 more sources

AmrZ is a major determinant of c-di-GMP levels in Pseudomonas fluorescens F113 [PDF]

, 2018
The transcriptional regulator AmrZ is a global regulatory protein conserved within the pseudomonads. AmrZ can act both as a positive and a negative regulator of gene expression, controlling many genes implicated in environmental adaption.
A Mortazavi, A Navazo, A Schäfer, AB Roy, AD Tischler, AH Tart, B Langmead, C Muriel, C Reichhardt, C Wei, CJ Jones, CJ Jones, CJ Jones, CW Phippen, D Amikam, E Barahona, E Barahona, E Peeters, EA Waligora, EO King, F Martinez-Granero, F Martinez-Granero, F Martinez-Granero, F Martinez-Granero, FM Scher, GL Winsor, H Li, HA Prada-Ramirez, ID Hay, IT Paulsen, JG Malone, LP Allsopp, M Lohse, ME Kovach, MI Love, MT Rybtke, N Ausmees, O Kirchner, PD Newell, PJ Baynham, PJ Baynham, R Simm, R Tamayo, RH Little, S Anders, S Capdevila, S Pfeilmeier, V Lorenzo de, WK Choy, Y Fouhy, ZT Guvener   +50 more
core   +3 more sources

The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex

Nucleic Acids Research, 2017
Streptomyces are ubiquitous soil bacteria that undergo a complex developmental transition coinciding with their production of antibiotics. This transition is controlled by binding of a novel tetrameric form of the second messenger, 3΄-5΄ cyclic diguanylic acid (c-di-GMP) to the master repressor, BldD.
Schumacher, Maria A., Zeng, Wenjie, Findlay, Kim C., Buttner, Mark J., Brennan, Richard G., Tschowri, Natalia   +5 more
openaire   +2 more sources

The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP

Frontiers in Microbiology, 2021
RNA chaperone protein Hfq is an important post-transcriptional regulator in bacteria, while c-di-GMP is a second messenger signaling molecule widely distributed in bacteria.
Yang Fu, Yang Fu, Zhaoqing Yu, Li Zhu, Zhou Li, Wen Yin, Xiaodong Shang, Shan-Ho Chou, Qi Tan, Jin He   +9 more
doaj   +1 more source

Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases [PDF]

, 2017
The bacterial second messenger cyclic di-3′,5′-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs)
A Deepthi, A Sundriyal, A Tchigvintsev, A Ueda, A Vagin, A Winkler, AD Tischler, AD Tischler, AJ Schmidt, B Huang, BW Holloway, C Chan, C Romier, CD Boyd, CW Phippen, D Balasubramanian, D Bellini, DA D’Argenio, DJ Hosfield, DL Caly, EF Pettersen, F Rao, F Rao, G Kuppuraj, G Minasov, G Winter, G Winter, GL Winsor, GN Murshudov, H Ceri, H Kulasakara, H Zheng, I Ivanov, ID Hay, J Robert-Paganin, JH Merritt, K Syson, K-H Choi, KD Miner, KM Thormann, M Christen, M Valentini, M Vorachit, MD Winn, MVAS Navarro, MY Galperin, N Barraud, O Kirillina, P Aldridge, P Emsley, P Evans, PD Newell, PR Evans, R Donlan, R Paul, R Simm, R Tamayo, RM Keegan, RP Ryan, RP Ryan, RZ Liao, TRM Barends, TT Hoang, U Römling, V Stelitano, VB Chen, W Grzybkowski, W Kabsch, Y Li, Y Qi, Y Wang   +70 more
core   +2 more sources

Local signaling enhances output specificity of bacterial c-di-GMP signaling networks [PDF]

, 2023
For many years the surprising multiplicity, signal input diversity, and output specificity of c-di-GMP signaling proteins has intrigued researchers studying bacterial second messengers.
Hengge, Regine, Junkermeier, Eike H.
core   +1 more source

Allosteric control of cyclic di-GMP signaling [PDF]

, 2006
Cyclic di-guanosine monophosphate is a bacterial second messenger that has been implicated in biofilm formation, antibiotic resistance, and persistence of pathogenic bacteria in their animal host.
Christen, B., Christen, M., Folcher, M., Jenal, U., Jenoe, P., Meuwly, M., Paul, R., Schmid, F.   +7 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source