Twofold C-H Activation-Based Enantio- and Diastereoselective C-H Arylation Using Diarylacetylenes as Rare Arylating Reagents [PDF]
, 2021 C-H bond activation has been established as an attractive strategy to access axially chiral biaryls, and the most straightforward method is direct C-H arylation of arenes.
Xingwei, Li +4 more
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Dual Catalytic C(sp2)–H Activation of Azaheterocycles towards C–N Atropisomers [PDF]
, 2023 We describe a PdII-catalyzed enantioselective C(heteroaryl)–H activation method enabled by a chiral transient directing group (cTDG) to gain access to C–N atropisomers.
Quynh, Wong +5 more
core +2 more sources
Tracking C–H activation with orbital resolution
Science, 2023 Transition metal reactivity toward carbon–hydrogen (C–H) bonds hinges on the interplay of electron donation and withdrawal at the metal center. Manipulating this reactivity in a controlled way is difficult because the hypothesized metal-alkane charge-transfer interactions are challenging to access experimentally. Using time-resolved x-ray spectroscopy,
Raphael M. Jay +23 more
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Direct Light Activation of Hypervalent Iodine Reagents: Substrate-Controlled C-C or C-H Alkynylation of Cyclopropanes [PDF]
, 2022 We report the direct light activation of ethynylbenziodoxolone (EBX) reagents for the oxyalkynylation of aryl- and amino-cyclopropanes as well as styrenes. Irradiation with visible light at 440 nm promoted the reaction without the need of a photocatalyst.
Tin. V. T. , Nguyen, Jerome, Waser
core +1 more source
Selectivity of C–H Activation and Competition between C–H and C–F Bond Activation at Fluorocarbons [PDF]
Chemical Reviews, 2017 Partially fluorinated alkanes, arenes, and alkenes can be transformed by a variety of transition metal and lanthanide systems. Although the C-H bond is weaker than the C-F bond regardless of the hybridization of the carbon, the reaction of the C-F bond at the metal is usually more exothermic than the corresponding reaction of the C-H bonds.
Odile Eisenstein +2 more
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Multiple C–H Activation Enabled Modular Construction of Densely Functionalized Sulfur-Contained Arenes [PDF]
, 2021 Modular construction of multiple functionalized arenes from abundant feedstocks, stands as an unremitting pursue goal in synthetic chemistry, which would accelerate the discovery of new drugs an advanced materials.
Jianhang, Rao +6 more
core +1 more source
Direct Aniline Formation with Benzene and Hydroxylamine
Chemistry, 2023 A single-step method for aniline formation was examined. Using a vanadate catalyst with an iron oxide co-catalyst and hydroxylamine hydrochloride as the amine source, an up to 90% yield of aniline was obtained with high selectivity.
Ningyu Liu +2 more
doaj +1 more source
Ruthenium-Catalyzed Oxidative Synthesis of N-(2-triazine)indoles by C-H Activation
Molecules, 2023 1,3,5 triazines, especially indole functionalized triazine derivatives, exhibit excellent activities, such as anti-tumor, antibacterial, and anti-inflammatory activities.
Ming Zeng +7 more
doaj +1 more source
Molecules, 2021 The regioselective C-H functionalization of the five-membered ring of the 6,5-fused heterocyclic systems is nowadays well documented due to its high reactivity compared to the six-membered ring.
Soukaina Faarasse +3 more
doaj +1 more source
Manganese-Catalyzed C–H Activation
ACS Catalysis, 2016 Manganese is found in the active center of numerous enzymes that operate by an outer-sphere homolytic C–H cleavage. Thus, a plethora of bioinspired radical-based C–H functionalizations by manganese catalysis have been devised during the past decades. In contrast, organometallic C–H activation by means of manganese catalysis has emerged only recently as
Weiping Liu, Lutz Ackermann
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