Results 41 to 50 of about 2,467,830 (354)
, 2023 Hydrogen isotope exchange (HIE) has emerged as a unique strategy for labelling, affording plenty of deuterated chemicals with varieties in patterns.
Jianfei, Bai +6 more
core +1 more source
Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
Nature Communications, 2021 Bioorthogonal diversification of peptides is generally dependent on impractical prefunctionalization methods. Here, the authors develop a manganese(I)-catalyzed C–H fluorescent labeling with BODIPY probes, which enables the development of activatable ...
Nikolaos Kaplaneris +7 more
doaj +1 more source
The ortho effect in directed C–H activation
Chemical Science, 2021 The term and concept of Ortho Effect (OE) is introduced for the description of steric effects in transition metal catalyzed directedorthoC–H activation reactions to explain and predict reactivities of substrates.
Tóth, Balázs L +7 more
openaire +5 more sources
, 2022 We report the direct light activation of ethynylbenziodoxolone (EBX) reagents for the oxyalkynylation of aryl- and amino-cyclopropanes as well as styrenes. Irradiation with visible light at 440 nm promoted the reaction without the need of a photocatalyst.
Tin. V. T. , Nguyen, Jerome, Waser
core +1 more source
Recent Advances on Synthetic Methodology Merging C–H Functionalization and C–C Cleavage
Molecules, 2020 The functionalization of C–H bonds has become a major thread of research in organic synthesis that can be assessed from different angles, for instance depending on the type of catalyst employed or the overall transformation that is carried out.
Hamid Azizollahi +1 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman +7 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási +14 more
wiley +1 more source
Cobalt-catalyzed nucleophilic addition of the allylic C(sp3)–H bond of simple alkenes to ketones
Beilstein Journal of Organic Chemistry, 2018 We herein describe a cobalt/Xantphos-catalyzed regioselective addition of simple alkenes to acetophenone derivatives, affording branched homoallylic alcohols in high yields with perfect branch selectivities.
Tsuyoshi Mita +3 more
doaj +1 more source
Catalytic Asymmetric Functionalization of Inert Bonds and Synthesis of Bioactive Natural Products
CHIMIA, 2011 The direct and enantioselective functionalization of inert bonds such as carbon–hydrogen and carbon–carbon is an emerging tool towards more sustainable and efficient synthetic methods.
Nicolai Cramer
doaj +1 more source
Electrochemical Cobalt‐Catalyzed C−H Activation
Chemistry – A European Journal, 2018 AbstractCarbon–heteroatom bonds represent omnipresent structural motifs of the vast majority of functionalized materials and bioactive compounds. C−H activation has emerged as arguably the most efficient strategy to construct C−Het bonds. Despite of major advances, these C−H transformations were largely dominated by precious transition metal catalysts,
Nicolas Sauermann +2 more
openaire +3 more sources