Results 41 to 50 of about 105,861 (299)

Selective Dealkenylative Functionalization of Styrenes via C-C Bond Cleavage

Research, 2020
As a readily available feedstock, styrene with about 25 million tons of global annual production serves as an important building block and organic synthon for the synthesis of fine chemicals, polystyrene plastics, and elastomers.
Jianzhong Liu, Jun Pan, Xiao Luo, Xu Qiu, Cheng Zhang, Ning Jiao   +5 more
doaj   +1 more source

Catalytic C−H Bond Functionalization with Palladium(II): Aerobic Oxidative Annulations of Indoles [PDF]

, 2003
A palladium-catalyzed aerobic oxidative annulation of indoles is described. We have demonstrated that a variety of factors influence these cyclizations, and in particular the electronic nature of the pyridine ligand is crucial. It is also remarkable that
Ferreira, Eric M., Stoltz, Brian M.
core   +2 more sources

Synthesis of Symmetrical and Unsymmetrical 1,3-Diheteroarylbenzenes Through Palladium-Catalyzed Direct Arylation of Benzene-1,3-disulfonyl Dichloride and 3-Bromobenzenesulfonyl Chlorides [PDF]

, 2015
International audienceThe palladium-catalyzed synthesis of unsymmetrical 1,3-diheteroarylbenzenes was investigated. The first synthetic pathway relies on the desymmetrization of benzene-1,3-disulfonyl dichloride through two successive palladium-catalyzed
Derridj, Fazia, Djebbar, Safia, Doucet, Henri, Idris, Imane, Soulé, Jean-François   +4 more
core   +2 more sources

Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles

Molecules, 2020
The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes,
Su Chen, Prabhat Ranjan, Leonid G. Voskressensky, Erik V. Van der Eycken, Upendra K. Sharma   +4 more
doaj   +1 more source

Recent advances in direct α-C(sp3)-H bond functionalization of thioethers

Green Synthesis and Catalysis, 2022
Thioether skeletons are widely present in drugs, natural products, functional materials, and life science. In the past decade, the selective C–H functionalization of thioethers has been extensively studied to construct novel thioether derivatives.
Long Tang, Qingyue Hu, Ke Yang, Mazen Elsaid, Chong Liu, Haibo Ge   +5 more
doaj   +1 more source

Synthesis of nitroxyl radical by direct nucleophilic functionalization of a C-H bond in the azadiene systems [PDF]

, 2012
Cyclic dinitrones underwent nucleophilic substitution of the hydrogen atom in the reaction with a paramagnetic carbanion, the lithium derivative of 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-1-oxyl 3-oxide, to give polyfunctional nitronyl nitroxyls ...
Bogomyakov, A. S., Chupakhin, O. N., Ovcharenko, V. I., Romanenko, G. V., Sagdeev, R. Z., Stass, D. V., Tretyakov, E. V., Utepova, I. A., Varaksin, M. V.   +8 more
core   +1 more source

C–H bond functionalizations with palladium(II): intramolecular oxidative annulations of arenes [PDF]

, 2008
Oxidative annulations for the synthesis of carbocycles were developed using a catalytic palladium(II) system. Indoles with pendant olefin tethers were oxidatively cyclized to form annulated products. Electron-rich aromatic systems were also investigated,
Ferreira, Eric M., Stoltz, Brian M., Zhang, Haiming   +2 more
core   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source