Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry
Molecules, 2023 Here, we report a tunable electrochemical benzylic C−H functionalization of (thio)xanthenes with terminal alkynes and nitriles in the absence of any catalyst or external chemical oxidant.
Changji Wang +4 more
doaj +1 more source
Highly Site-Selective Direct C−H Bond Functionalization of Unactivated Arenes with Propargyl α‑Aryl-α-diazoacetates via Scandium Catalysis [PDF]
, 2021 Highly chemo- and regio-selective C–H bond functionalization of unactivated arenes with propargyl α-aryl-α-diazoacetates is developed using scandium catalysis.
Kumar, Vanka +4 more
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Strategies to transform remote C(sp3)-H bonds of amino acid derivatives
Tetrahedron Chem, 2022 Amino acids and peptides play an important role in nature as well as in the pharmaceutical industry. Therefore, transformation of amino acids and peptides into their unnatural derivatives via step and atom economical ways is highly demanding. Although, a
Supreeta Sen +2 more
doaj +1 more source
Enantioselective Single and Dual a-C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer [PDF]
, 2022 Cyclic amines are ubiquitous structural motifs found in pharmaceuticals and biologically active natural products, making methods for their elaboration via direct C–H functionalization of considerable synthetic value.
Bo M. , Couture +5 more
core +2 more sources
Coumarins Synthesis and Transformation via C–H Bond Activation—A Review
Inorganics, 2022 For several decades, coumarins have attracted considerable attention due to the fact of their application in diverse fields such as medical science and biomedical research as well as several industrial branches.
Katarzyna Szwaczko
doaj +1 more source
Cobalt catalyzed decarbonylative ipso-C-C bond functionalization: Synthesis of Indole C-3 functionalized acyloins using 1,2-diketone [PDF]
, 2022 Selective functionalization of indole C3-C bond with aromatic/heteroaromatic 1,2-diketones has been uncovered for the first time. Earth crust abundant first-row transition metal cobalt catalyst has been demonstrated as an effective catalyst for this ...
Saista , Afreen +5 more
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A Simple Access to γ‐ and ε‐Keto Arenes via Enzymatic Divergent C─H Bond Oxyfunctionalization
Advanced Science, 2023 Performing divergent C─H bond functionalization on molecules with multiple reaction sites is a significant challenge in organic chemistry. Biocatalytic oxyfunctionalization reactions of these compounds to the corresponding ketones/aldehydes are typically
Huanhuan Li +6 more
doaj +1 more source
Arenes and Heteroarenes C–H Functionalization Under Enabling Conditions: Electrochemistry, Photoelectrochemistry & Flow Technology [PDF]
, 2023 C-H bond functionalization generates molecular complexity in single-step transformation. However, the activation of C-H bonds requires expensive metals or stoichiometric amounts of oxidizing/reducing species.
Ayesha , Murtaza +6 more
core +1 more source
Anaerobic functionalization of unactivated C–H bonds [PDF]
Current Opinion in Chemical Biology, 2009 The functionalization of alkanes was once thought to lie strictly within the domain of enzymes that activate dioxygen in order to generate an oxidant with suitable potency to cleave inert C-H bonds. The emergence of the radical SAM superfamily of enzymes-those which use S-adenosyl-l-methionine as a precursor to a 5'-deoxyadenosyl 5'-radical-has kindled
openaire +2 more sources
Enantioselective C–P Bond Formation through C(sp3)–H Functionalization [PDF]
, 2023 An unprecedented enantioselective C–P bond formation has been developed through a C(sp3)–H activation in an oxidation step followed by an organocatalyzed hydrophosphonylation protocol. The asymmetric organocatalytic Pudovik reaction has been successfully
Devan , Horn +6 more
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