Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase [PDF]
, 2001 The endophilin family of proteins function in clathrin-mediated endocytosis. Here, we have identified and cloned the rat germinal center kinase-like kinase (rGLK), a member of the GCK (germinal center kinase) family of e-Jun N-terminal kinase (JNK ...
Angers, Annie +4 more
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Baicalin modulates apoptosis via RAGE, MAPK, and AP-1 in vascular endothelial cells during invasion
Innate Immunity, 2019 Glässer’s disease, caused by Haemophilus parasuis , is a chronic disease related to an inflammatory immune response. Baicalin exerts important biological functions.
Shulin Fu +10 more
doaj +1 more source
A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells. [PDF]
PLoS ONE, 2017 c-Jun, c-Jun N-terminal kinase(JNK) and endothelin B (ETB) receptor have been shown to contribute to the pathogenesis of glaucoma. Previously, we reported that an increase of c-Jun and CCAAT/enhancer binding protein β (C/EBPβ) immunohistostaining is ...
Junming Wang +4 more
doaj +1 more source
Prolactin Stimulates Activation of c-jun N-Terminal Kinase (JNK) [PDF]
Molecular Endocrinology, 2000 In recent years the mitogen-activated protein (MAP) kinase family has expanded to include both c-jun N-terminal kinases (JNKs), and the p38/HOG1 family in addition to the extracellular regulated kinase (ERK) family. These kinases are activated by a variety of growth factors, as well as extra- and intracellular insults such as osmotic stress, UV light ...
K L, Schwertfeger +6 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Angiotensin II type 1 receptor blockers (ARBs) have been shown to limit the growth of abdominal aortic aneurysm (AAA), but their efficacy is controversial.
Kohei Karasaki +6 more
doaj +1 more source
C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation [PDF]
, 2012 Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis ...
Czerny, Christoph +6 more
core +2 more sources
Docking Interactions in the c-Jun N-terminal Kinase Pathway [PDF]
Journal of Biological Chemistry, 2004 The c-Jun N-terminal kinase (JNK) signaling pathway is a major mediator of stress responses in cells. Similar to other mitogen-activated protein kinases (MAPKs), JNK activity is controlled by a cascade of protein kinases and by protein phosphatases, including dual-specificity MAPK phosphatases.
Mooney, Lorraine M., Whitmarsh, Alan J.
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Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
Cells, 2020 Obesity has been described as a global epidemic and is a low-grade chronic inflammatory disease that arises as a consequence of energy imbalance. Obesity increases the risk of type 2 diabetes (T2D), by mechanisms that are not entirely clarified. Elevated
Justin Hou Ming Yung, Adria Giacca
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c-Jun N-Terminal Kinase Signaling Inhibitors Under Development [PDF]
Toxicological Research, 2008 Targeting protein kinases has been active area in drug discovery. The c-Jun N-terminal kinases (JNKs) have also been target for development of novel therapy in various diseases, since the roles of JNK signaling in pathological conditions were revealed in studies using jnk-deficient mice.
openaire +2 more sources
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]
, 2014 Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K +6 more
core +3 more sources