Results 61 to 70 of about 195,376 (282)
Induction of endothelial cell proliferation by recombinant and microparticle-tissue factor involves β1-integrin and extracellular signal regulated kinase activation [PDF]
, 2010 Objective: Increased levels of circulating tissue factor (TF) in the form of microparticles increase the risk of thrombosis. However, any direct influence of microparticle-associated TF on vascular endothelial cell proliferation is not known.
Collier, Mary E. W., Ettelaie, Camille
core +1 more source
Inhibitors of c-Jun N-terminal kinases—JuNK no more?
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2008 The c-Jun N-terminal kinases (JNKs) have been the subject of intense interest since their discovery in the early 1990s. Major research programs have been directed to the screening and/or design of JNK-selective inhibitors and testing their potential as drugs.
Bogoyevitch, MA, Arthur, PG
openaire +3 more sources
Analysis of the Interaction between c-Jun and c-Jun N-terminal Kinase in Vivo [PDF]
Journal of Biological Chemistry, 1998 Regulation of c-Jun transcriptional activity is believed to depend on a physical interaction with c-Jun N-terminal kinase (JNK) that facilitates signal-regulated phosphorylation of multiple regulatory phosphoacceptor sites within the activation domain. Here we have investigated the structural requirements and consequences of regulatory phosphorylation ...
G H, May +4 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Specific inhibition of c-Jun N-terminal kinase delays preterm labour and reduces mortality [PDF]
, 2015 Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (LPS) from different bacteria can be used to independently or mutually activate Jun N-terminal kinase (JNK)/AP1- or NF-kB-driven inflammatory pathways that
Bennett, Phillip R. +6 more
core +2 more sources
Advanced Functional Materials, EarlyView.This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv +10 more
wiley +1 more source
Frontiers in Genetics, 2019 Mitogen-activated protein kinases (MAPKs) play a regulatory role and influence various biological activities, such as cell proliferation, differentiation, and survival.
Sandra Grossi Gava +5 more
doaj +1 more source
Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense. [PDF]
PLoS ONE, 2012 The c-Jun N-terminal kinase (JNK) - 1 pathway has been implicated in the cellular response to stress in many tissues and models. JNK1 is known to play a role in a variety of signaling cascades, including those involved in lung disease pathogenesis ...
Jos Van der Velden +5 more
doaj +1 more source
C-Jun N-terminal kinase (JNK) pathway activation is essential for dental papilla cells polarization.
PLoS ONE, 2021 During tooth development, dental papilla cells differentiate into odontoblasts with polarized morphology and cell function. Our previous study indicated that the C-Jun N-terminal kinase (JNK) pathway regulates human dental papilla cell adhesion ...
Jiao Luo +3 more
doaj +1 more source
Activation of kinase phosphorylation by heat-shift and mild heat-shock [PDF]
, 2010 Most cells activate intracellular signalling to recover from heat damage. An increase of temperature, known as HS (heat shock), induces two major signalling events: the transcriptional induction of HSPs (heat-shock proteins) and the activation of the ...
Mongiardi, MP +4 more
core +2 more sources