Results 251 to 260 of about 19,933,051 (310)

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

Toosendanin suppresses acute myeloid leukemia by targeting DDX5/c-Myc axis to inhibit protein synthesis. [PDF]

J Transl Med
He X, Chen Z, Luo J, Chen H, Hou Y, Liu D, Liu Y.   +6 more
europepmc   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

KDM8/c-Myc axis-mediated glucose metabolism reprogramming promotes the progression of ovarian cancer. [PDF]

Sci Rep
Liu C, Xu Q, Li Z, Yang X, Mao B, Guo L, Liu X, Liu W.   +7 more
europepmc   +1 more source

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

Carrier-free nanomodulators reprogramming acetate metabolism for cancer photo-immunotherapy via c-Myc inhibition-induced closed-loop regulatory circuit. [PDF]

Mater Today Bio
Zhu J, Dong D, Xu J, Tang X, Gao Y, Zhu J, Zhuang Y, Zhang P, Lv Z, Chen X, Zou J, Shi H.   +11 more
europepmc   +1 more source

A positive feedback loop between TKT and c-Myc drives TACE resistance in hepatocellular carcinoma. [PDF]

Cell Death Discov
Xiao Y, Liu M, Zhou Y, Bao Y, Zhang G, Xu B, Zheng W, Zhao H.   +7 more
europepmc   +1 more source

Inhibition of RBM23 induces ferroptosis in colon cancer cells via c-Myc regulation. [PDF]

Cancer Cell Int
Oh JJ, Lee YJ, Han YJ, Park J, Kim W, Lee IS, Lee S, Jo MG, Jung JH.   +8 more
europepmc   +1 more source

An antibody-PROTAC conjugate targets BRD4/c-Myc/PD-L1 to enhance immunotherapy efficacy in triple-negative breast cancer. [PDF]

Cell Rep Med
Gu Y, Li C, Zhao Y, Xu T, Zhu Y, Wang D, Wang X, Chen J, Li J, Guan X.   +9 more
europepmc   +1 more source