Results 261 to 270 of about 19,933,051 (310)

Switching of the c-Myc protein degradation pathway depending on the PP2A-B55α complex levels. [PDF]

Proc Natl Acad Sci U S A
Ando S, Ikeda S, Tanaka K, Tomabechi Y, Yamagata A, Shirouzu M, Tsunedomi R, Nagano H, Tsuji S, Sato K, Ohama T.   +10 more
europepmc   +1 more source

miRNA‑29a inhibits the proliferation of HUVECs by regulating the ITGB1/β‑catenin/c‑Myc pathway. [PDF]

Mol Med Rep
Sun Q, Chen W, Zhang S, Zhong X, Wu Y, Qian Y, Zhu L, Zhang T, Li W.   +8 more
europepmc   +1 more source

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c-Myc-driven Hepatocarcinogenesis

Anticancer Research, 2021
Dysregulation of the c-Myc gene is frequently found in human hepatocellular carcinoma (HCC), often accompanied by genetic and epigenetic alterations in other cancer-related genes. Here, we investigated the tumorigenic potential of c-Myc in diverse genetic environments in which the Ras, Wnt/β-catenin, Sonic hedgehog, or P53 pathways were either ...
Hyuk, Moon, Hyunjung, Park, Simon Weonsang, Ro   +2 more
openaire   +2 more sources

Association with C-Myc: An Alternated Mechanism for c-Myc Function

1995
The c-myc proto-oncogene encodes a ubiquitously expressed nuclear phospho-protein that is involved in the control of cellular proliferation and differentiation (1, 2, 3). Alteration of the c-myc locus by chromosomal translocation, amplification or retroviral insertion is often associated with tumorigenesis in different species including humans (1, 3 ...
A, Shrivastava, K, Calame
openaire   +2 more sources

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

The International Journal of Biochemistry & Cell Biology, 2011
The c-Myc oncoprotein plays critical roles in multiple biological processes by controlling cell proliferation, apoptosis, differentiation, and metabolism. Especially, c-Myc is frequently overexpressed in many human cancers and widely involved in tumorigenesis.
Beibei, Mao, Guowei, Zhao, Xiang, Lv, Hou-Zao, Chen, Zheng, Xue, Ben, Yang, De-Pei, Liu, Chih-Chuan, Liang   +7 more
openaire   +2 more sources

A transcriptional repressor of c-myc

Nature, 1989
In murine plasmacytomas there is deregulated transcription of a translocated c-myc allele and undetectable transcription of the normal, unrearranged c-myc allele. Deregulated c-myc transcription probably contributes to the transformed phenotype of the tumour cells, whereas repression of the normal allele probably reflects the normal turn-off of c-myc ...
E, Kakkis, K J, Riggs, W, Gillespie, K, Calame   +3 more
openaire   +2 more sources

Function of the c‐Myc oncoprotein

The FASEB Journal, 1992
The c‐Myc protein, the product of the c‐myc proto‐oncogene, is a nuclear phosphoprotein with DNA binding properties. Deregulated c‐myc expression participates in the development of experimentally induced tumors, and its expression appears to be abnormal
G J, Kato, C V, Dang
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The many faces of c-MYC

Archives of Biochemistry and Biophysics, 2003
The proto-oncogene c-MYC is implicated in various physiological processes-cell growth, proliferation, loss of differentiation, and cell death (apoptosis). Oncogenic c-MYC implies constitutive or deregulated expression of c-MYC and is associated with many human cancers often with poor prognosis.
Stella, Pelengaris, Mike, Khan
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Expression of c-myc and Pvt1

1990
Deregulated expression of c-myc secondary to chromosomal alterations is a constant feature of mouse plasmacytomas, rat immunocytomas and human Burkitt lymphomas (Mushinski, 1988). One feature of deregulated expression of c-myc is that all plasmacytomas have high levels of c-myc transcripts, no matter whether their chromosome 15 was interrupted by a ...
J F, Mushinski, R M, Skurla, J, Goodnight, D, Siwarski, K, Huppi   +4 more
openaire   +2 more sources