Results 11 to 20 of about 2,150,147 (255)

C-Type Lectin Receptors in Host Defense Against Bacterial Pathogens

Frontiers in Cellular and Infection Microbiology, 2020
Antigen-presenting cells (APCs) are present throughout the human body—in tissues, at barrier sites and in the circulation. They are critical for processing external signals to instruct both local and systemic responses toward immune tolerance or immune ...
Malgorzata E. Mnich, Malgorzata E. Mnich, Rob van Dalen, Nina M. van Sorge, Nina M. van Sorge   +4 more
doaj   +2 more sources

Structurally Robust and Functionally Highly Versatile—C-Type Lectin (-Related) Proteins in Snake Venoms

Toxins, 2019
Snake venoms contain an astounding variety of different proteins. Among them are numerous C-type lectin family members, which are grouped into classical Ca2+- and sugar-binding lectins and the non-sugar-binding snake venom C-type lectin-related proteins (
Johannes A. Eble
doaj   +2 more sources

Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity

Frontiers in Immunology, 2018
Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity.
Juan Tang, Guoxin Lin, Guoxin Lin, Wallace Y. Langdon, Lijian Tao, Jian Zhang   +5 more
doaj   +2 more sources

C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

Frontiers in Immunology, 2018
C-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an important role in viral infections as they efficiently interact with viruses. However,
Marta Bermejo-Jambrina, Marta Bermejo-Jambrina, Julia Eder, Leanne C. Helgers, Nina Hertoghs, Bernadien M. Nijmeijer, Melissa Stunnenberg, Teunis B. H. Geijtenbeek   +7 more
doaj   +2 more sources

Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity

Frontiers in Immunology, 2017
The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,
Emmanuel C. Patin, Emmanuel C. Patin, Selinda Jane Orr, Ulrich E. Schaible   +3 more
doaj   +2 more sources

The diverse roles of C-type lectin-like receptors in immunity

Frontiers in Immunology, 2023
Our understanding of the C-type lectin-like receptors (CTLRs) and their functions in immunity have continued to expand from their initial roles in pathogen recognition.
Michael D. Scur, B. Parsons, S. Dey, A. Makrigiannis   +3 more
semanticscholar   +1 more source

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Immunity, 2021
Despite mounting evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) engagement with immune cells, most express little, if any, of the canonical receptor of SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2).
Qiao Lu, Jia Liu, Shuai Zhao, Maria Florencia Gomez Castro, Maudry Laurent-Rolle, Jianbo Dong, Xiaojuan Ran, P. Damani-Yokota, Hongzhen Tang, Triantafyllia Karakousi, Juhee Son, M. Kaczmarek, Ze Zhang, S. Yeung, B. McCune, Rita E. Chen, Fei Tang, Xianwen Ren, Xufeng Chen, Jack Chun-Chieh Hsu, M. Teplova, Betty C. B. Huang, Hai-Jing Deng, Zhilin Long, Tenny Mudianto, Shumin Jin, Peng Lin, Jasper Du, Ruochen Zang, T. T. Su, A. Herrera, Ming Zhou, R. Yan, Jia-cheng Cui, James Zhu, Qiang Zhou, Tao Wang, Jian-xiong Ma, Sergei B Koralov, Ze Zhang, I. Aifantis, L. Segal, M. Diamond, K. Khanna, Kenneth A. Stapleford, P. Cresswell, Yue Liu, Siyuan Ding, Qi Xie, Jun Wang   +49 more
semanticscholar   +1 more source

Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom

Scientific Reports, 2022
Convulxin (CVX), a C-type lectin-like protein isolated from the venom of the snake species, Crotalus durissus terrificus, stimulates platelet aggregation by acting as a collagen receptor agonist for glycoprotein VI found in the platelets.
C. Rego, A. Francisco, C. N. Boeno, M. V. Paloschi, J. A. Lopes, M. D. Silva, H. M. Santana, S. N. Serrath, Jaína E Rodrigues, Caleb T L Lemos, Ricardo P S Dutra, J. N. da Cruz, C. B. R. dos Santos, Sulamita da S. Setúbal, M. Fontes, A. Soares, W. L. Pires, J. Zuliani   +17 more
semanticscholar   +1 more source

Ligand Recognition by the Macrophage Galactose-Type C-Type Lectin: Self or Non-Self?—A Way to Trick the Host’s Immune System

International Journal of Molecular Sciences, 2023
The cells and numerous macromolecules of living organisms carry an array of simple and complex carbohydrates on their surface, which may be recognized by many types of proteins, including lectins.
Justyna Szczykutowicz
semanticscholar   +1 more source

C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis

Nature Communications, 2022
Macrophages are integral to the pathogenesis of atherosclerosis, but the contribution of distinct macrophage subsets to disease remains poorly defined. Using single cell technologies and conditional ablation via a LysM Cre+ Clec4a2 flox/DTR mouse strain,
I. Park, M. Goddard, J. Cole, Natacha Zanin, L. Lyytikäinen, T. Lehtimäki, E. Andreakos, M. Feldmann, I. Udalova, I. Drozdov, C. Monaco   +10 more
semanticscholar   +1 more source